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T Cell Immunoglobulin and Mucin Domain Containing 2 Proteins (TIMD2)

Probable receptor for SEMA4A involved in the regulation of T-cell function. Additionally we are shipping TIMD2 Antibodies (13) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
TIMD2 171284 Q8R183
TIMD2 287222 Q5FVR0
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Top TIMD2 Proteins at antibodies-online.com

Showing 3 out of 3 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
Insect Cells Mouse rho-1D4 tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 0.25 mg Log in to see 49 to 54 Days
$4,244.78
Details
HOST_Escherichia coli (E. coli) Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
Yeast Rat His tag   1 mg Log in to see 56 to 66 Days
$2,656.50
Details

TIMD2 Proteins by Origin and Source

Origin Expressed in Conjugate
Mouse (Murine) ,
,
Rat (Rattus)

More Proteins for T Cell Immunoglobulin and Mucin Domain Containing 2 (TIMD2) Interaction Partners

Mouse (Murine) T Cell Immunoglobulin and Mucin Domain Containing 2 (TIMD2) interaction partners

  1. We concluded that pro-apoptotic effects on Th1 (show HAND1 Proteins) population through galectin-9 (show LGALS9 Proteins)-Tim-3 (show HAVCR2 Proteins) pathway and the up-regulation of Tim-2 on Th2 cells might be critical to Th2-biased response of host with schistosomiasis japonica.

  2. TIM-2 signaling influences both proliferation and antibody production of B cells during the early phase of collagen-induced arthritis

  3. TIM-2 can function as an iron uptake pathway.

  4. The increased expression of the pro-inflammatory and proapoptotic genes, a higher number of apoptotic cells, and increased injury and mortality of the TIM2-deficient mice suggest a protective role of TIM2 in cisplatin-induced nephrotoxicity.

  5. TIM-2 is expressed on B cells and in liver and kidney and is a receptor for H-ferritin endocytosis.

  6. expression of TIM-2 significantly impairs the induction of NFAT (show NFATC1 Proteins) and AP-1 (show JUN Proteins) transcriptional reporters

  7. The mTIM-1 structure identified a homophilic TIM-TIM adhesion interaction, whereas the mTIM-2 domain formed a dimer that prevented homophilic binding.

  8. There are Tim2-binding molecules on hepatocytes. Tim2-hFc inhibited differentiation & proliferation of hepatocytes in fetal liver primary culture. Down-regulation of Tim2 expression by siRNA enhanced expression of liver differentiation marker genes.

  9. Tim-2 negatively regulates the Th2 differentiation of Ag-primed T-cells and the development of EC during the effector phase.

TIMD2 Protein Profile

Protein Summary

Probable receptor for SEMA4A involved in the regulation of T-cell function. The interaction with SEMA4A enhances T-cell activation (By similarity).

Gene names and symbols associated with TIMD2

  • T cell immunoglobulin and mucin domain containing 2 (Timd2)
  • T-cell immunoglobulin and mucin domain containing 2 (Timd2)
  • AA816106 protein
  • AU019358 protein
  • AU019662 protein
  • C78111 protein
  • G9D3 protein
  • TIM-2 protein
  • Tim2 protein

Protein level used designations for TIMD2

T-cell immunoglobulin and mucin domain containing 2 , T-cell immunoglobulin and mucin domain-containing protein 2 , T-cell membrane protein 2 , TIMD-2 , TIM-2

GENE ID SPECIES
171284 Mus musculus
287222 Rattus norvegicus
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