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Probable receptor for SEMA4A involved in the regulation of T-cell function. Additionally we are shipping TIMD2 Antibodies (13) and many more products for this protein.
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We concluded that pro-apoptotic effects on Th1 (show HAND1 Proteins) population through galectin-9 (show LGALS9 Proteins)-Tim-3 (show HAVCR2 Proteins) pathway and the up-regulation of Tim-2 on Th2 cells might be critical to Th2-biased response of host with schistosomiasis japonica.
TIM-2 signaling influences both proliferation and antibody production of B cells during the early phase of collagen-induced arthritis
TIM-2 can function as an iron uptake pathway.
The increased expression of the pro-inflammatory and proapoptotic genes, a higher number of apoptotic cells, and increased injury and mortality of the TIM2-deficient mice suggest a protective role of TIM2 in cisplatin-induced nephrotoxicity.
TIM-2 is expressed on B cells and in liver and kidney and is a receptor for H-ferritin endocytosis.
expression of TIM-2 significantly impairs the induction of NFAT (show NFATC1 Proteins) and AP-1 (show JUN Proteins) transcriptional reporters
The mTIM-1 structure identified a homophilic TIM-TIM adhesion interaction, whereas the mTIM-2 domain formed a dimer that prevented homophilic binding.
There are Tim2-binding molecules on hepatocytes. Tim2-hFc inhibited differentiation & proliferation of hepatocytes in fetal liver primary culture. Down-regulation of Tim2 expression by siRNA enhanced expression of liver differentiation marker genes.
Tim-2 negatively regulates the Th2 differentiation of Ag-primed T-cells and the development of EC during the effector phase.
Probable receptor for SEMA4A involved in the regulation of T-cell function. The interaction with SEMA4A enhances T-cell activation (By similarity).
T-cell immunoglobulin and mucin domain containing 2
, T-cell immunoglobulin and mucin domain-containing protein 2
, T-cell membrane protein 2