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T-Box 20 Proteins (TBX20)

TBX20 encodes a T-box family member. Additionally we are shipping TBX20 Antibodies (28) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
TBX20 57057 Q9UMR3
TBX20 57246 Q9ES03
Rat TBX20 TBX20 315497  
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Top TBX20 Proteins at

Showing 8 out of 9 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
HOST_Escherichia coli (E. coli) Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific pu... 1 mg Log in to see 29 to 34 Days
HOST_Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific pu... 1 mg Log in to see 29 to 34 Days
HOST_Wheat germ Human GST tag 10 μg Log in to see 9 Days
Yeast Xenopus tropicalis His tag   1 mg Log in to see 56 to 66 Days
Yeast Chicken His tag   1 mg Log in to see 56 to 66 Days
Yeast Xenopus laevis His tag   1 mg Log in to see 56 to 66 Days
Yeast Zebrafish His tag   1 mg Log in to see 56 to 66 Days
HOST_Human Human Un-conjugated   20 μg Log in to see 9 to 11 Days

TBX20 Proteins by Origin and Source

Origin Expressed in Conjugate
Human , ,
Mouse (Murine)

More Proteins for T-Box 20 (TBX20) Interaction Partners

Zebrafish T-Box 20 (TBX20) interaction partners

  1. data demonstrate that elevated glucose alone induces cardiac defects in zebrafish embryos by altering the expression pattern of tbx5 (show TBX5 Proteins), tbx20, and has2 (show HAS2 Proteins) in the heart

  2. embryos lacking hrT function have dysmorphic hearts and an absence of blood circulation

  3. redundant activities of Nkx2.5 and Nkx2.7 are required for cardiac morphogenesis, but Nkx2.7 plays a more critical function, regulating the expressions of tbx5 (show TBX5 Proteins) and tbx20 through the maturation stage

Xenopus laevis T-Box 20 (TBX20) interaction partners

  1. we show that TBX5 (show TBX5 Proteins) and TBX20 can physically interact and map the interaction domains, and we show a cellular interaction for the two proteins in cardiac development

Human T-Box 20 (TBX20) interaction partners

  1. We report three missense mutations (Y309D, T370O, and M395R) within the transcriptional activator domain of human TBX20 that were associated with atrial septal defect

  2. Data showed that the TC genotype of SNP rs3999941 and AC genotype of the new SNP c.657A>C in the TBX20 gene may be risk factors for CHD (show CHDH Proteins).

  3. TBX20 loss-of-function mutation contributes to double outlet right ventricle

  4. A novel TBX20 mutation, c.526G>A (p.D176N), was identified and co-segregated in all affected members in this family of three generations with atrial septal defects.

  5. Tbx20 regulated PPAR-gamma (show PPARG Proteins) expression and protected the vascular endothelial cells from oxidized low-density lipoprotein -induced injury.

  6. Tbx20 functions as an important regulator of estrogen-mediated cardiomyocyte protection during oxidative stress.

  7. Study identified one novel heterozygous sequence variant within the proximal promoter region of TBX20 gene in a ventricular septal defects patient, which inhibited transcriptional activities of TBX20 gene promoter; data provide new information to help understanding of genetic causes and molecular mechanisms of congenital heart disease.

  8. This novel interaction between TBX20b and MKLN1 (show MKLN1 Proteins) may help elucidate new regulatory mechanisms within heart development.

  9. Found tertiary hydrophobic interactions within the mutant TBX20 T-box of Ostium secundum atrial septal defect subjects were significantly altered leading to a more dynamic structure of the protein.

  10. Our findings are the first to link TBX20 mutations to human pathology

Mouse (Murine) T-Box 20 (TBX20) interaction partners

  1. Cardiomyocyte Tbx20 induced overexpression activates multiple cardiac proliferative pathways, directly represses cell-cycle inhibitory genes p21, Meis1 (show MEIS1 Proteins), and Btg2 (show BTG2 Proteins), promotes adult CM proliferation; and preserves cardiac performance after MI.

  2. TLE1 (show TLE1 Proteins)/TLE3-NuRD corepressor complex facilitates Tbx20-dependent transcriptional repression.

  3. The effects of Tbx20 are epistatic to Tbx3 (show TBX3 Proteins) in the heart, but Tbx3 (show TBX3 Proteins) is epistatic to Tbx20 with respect to developmental delay.

  4. Tbx20-mediated increases in cell proliferation, providing evidence for parallel regulatory pathways downstream of BMP/Smad1 (show SMAD1 Proteins)/5/8 signaling in promoting cardiomyocyte proliferation after birth

  5. Tbx20 is expressed in the developing endocardial cushions and valves throughout heart development. Ablation of Tbx20 in endocardial cells causes severe valve elongation defects and impaired cardiac function.

  6. a dual role for TBX20 as both a transcriptional activator and a repressor, and that each of these functions regulates genes with very specialized and distinct molecular roles

  7. Data show distinct functions for Tbx20 in regulation of cardiomyocyte lineage maturation and cell proliferation at embryonic and fetal stages of heart development.

  8. Genome-wide ChIP analysis of Tbx20-binding regions in the adult heart revealed that many of these genes were direct downstream targets of Tbx20 and uncovered a previously undescribed DNA-binding site for Tbx20.

  9. mice lacking Tbx20 in the atrioventricular canal myocardium fail to form the atrioventricular canal constriction, and the endocardial epithelial-mesenchymal transition (EMT (show ITK Proteins)) is severely perturbed.

  10. the BMP10 (show BMP10 Proteins)-Tbx20 signaling cascade is important for ventricular wall development and maturation.

TBX20 Protein Profile

Protein Summary

This gene encodes a T-box family member. The T-box family members share a common DNA binding domain, termed the T-box, and they are transcription factors involved in the regulation of developmental processes. This gene is essential for heart development. Mutations in this gene are associated with diverse cardiac pathologies, including defects in septation, valvulogenesis and cardiomyopathy. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.

Gene names and symbols associated with T-Box 20 Proteins (TBX20)

  • T-box 20 (TBX20)
  • T-box 20 (tbx20)
  • T-box 20 (LOC100225521)
  • Tbx20-like homeobox protein (tbx20)
  • T-box 20 (Tbx20)
  • T-box transcription factor TBX20-like (TBX20)
  • 9430010M06Rik protein
  • AL022859 protein
  • ASD4 protein
  • cb826 protein
  • hrt protein
  • Tbx12 protein
  • tbx20 protein
  • tbx20-A protein
  • XTBX20 protein
  • ZF-TBX20 protein

Protein level used designations for T-Box 20 Proteins (TBX20)

T-box 20 , T-box transcription factor 20 , Tbx20-like homeobox protein , H15-related T-box transcription factor hrT , T-box protein 20 , T-box transcription factor TBX20 , cTbx20

467053 Pan troglodytes
619590 Xenopus (Silurana) tropicalis
100070390 Equus caballus
100225521 Taeniopygia guttata
100303555 Saccoglossus kowalevskii
57936 Danio rerio
378656 Xenopus laevis
373943 Gallus gallus
57057 Homo sapiens
539419 Bos taurus
57246 Mus musculus
315497 Rattus norvegicus
482396 Canis lupus familiaris
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