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anti-T-Cell Leukemia Homeobox 1 (TLX1) Antibodies

TLX1 encodes a nuclear transcription factor that belongs to the NK-linked or NK-like (NKL) subfamily of homeobox genes. Additionally we are shipping TLX1 Proteins (3) and many more products for this protein.

list all antibodies Gene Name GeneID UniProt
TLX1 21908  
TLX1 3195 P31314
TLX1 499361  
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Top anti-TLX1 Antibodies at antibodies-online.com

Showing 10 out of 38 products:

Catalog No. Reactivity Host Conjugate Application Images Quantity Supplier Delivery Price Details
Chicken Rabbit Un-conjugated WB WB Suggested Anti-TLX1 Antibody Titration: 0.2-1 ug/mlELISA Titer: 1:1562500Positive Control: 721_B cell lysate WB Suggested Anti-TLX1  Antibody Titration: 0.2-1 µg/mL ELISA Titer: 1:1562500  Positive Control:.21_B cell lysate  TLX1 is supported by BioGPS gene expression data to be expressed in 721_B 100 μL Log in to see 2 to 3 Days
$289.00
Details
Chicken Rabbit Un-conjugated WB WB Suggested Anti-TLX1 Antibody Titration: 0.2-1 ug/mlELISA Titer: 1:312500Positive Control: Human heart 100 μL Log in to see 2 to 3 Days
$289.00
Details
Human Rabbit Un-conjugated EIA, WB TLX1 Antibody (Center) western blot analysis in mouse kidney tissue lysates (35 µg/lane). This demonstrates the TLX1 antibody detected the TLX1 protein (arrow). 0.4 mL Log in to see 6 to 8 Days
$390.50
Details
Mouse Rabbit Un-conjugated WB TLX1 Antibody (Center) (ABIN656421) western blot analysis in mouse kidney tissue lysates (35 µg/lane). This demonstrates the TLX1 antibody detected the TLX1 protein (arrow). 400 μL Log in to see 10 to 11 Days
$324.50
Details
Human Rabbit Un-conjugated IHC (p), WB 50 μg Log in to see 6 to 8 Days
$500.50
Details
Human Rabbit Un-conjugated IHC (p), WB Human Thymus (formalin-fixed, paraffin-embedded) stained with TLX1 antibody ABIN297247 at 5 ug/ml followed by biotinylated goat anti-rabbit IgG secondary antibody ABIN481713, alkaline phosphatase-streptavidin and chromogen. 50 μg Log in to see 8 to 10 Days
$451.00
Details
Human Rabbit Un-conjugated WB 50 μg Log in to see 8 to 10 Days
$551.83
Details
Human Rabbit Un-conjugated WB 50 μg Log in to see 8 to 10 Days
$551.83
Details
Human Rabbit Un-conjugated ELISA, WB 50 μg Log in to see 2 to 3 Days
$433.13
Details
Bat Rabbit Un-conjugated IHC, WB 0.05 mg Log in to see 2 to 3 Days
$481.25
Details

TLX1 Antibodies by Reactivity, Application, Clonality and Conjugate

Attributes Applications Host Clonality Conjugate
Mouse (Murine)


, , , , ,
Human ,


Rat (Rattus)


Top referenced anti-TLX1 Antibodies

  1. Human Polyclonal TLX1 Primary Antibody for EIA, WB - ABIN955235 : De Keersmaecker, Real, Gatta, Palomero, Sulis, Tosello, Van Vlierberghe, Barnes, Castillo, Sole, Hadler, Lenz, Aplan, Kelliher, Kee, Pandolfi, Kappes, Gounari, Petrie, Van der Meulen, Speleman, Paietta, Racevskis, Wiernik, Rowe, Soulier, Avran, Cavé, Dast: The TLX1 oncogene drives aneuploidy in T cell transformation. in Nature medicine 2010 (PubMed)
    Show all 3 references for ABIN955235

  2. Chicken Polyclonal TLX1 Primary Antibody for WB - ABIN2780689 : Baak, Gökbuget, Orawa, Schwartz, Hoelzer, Thiel, Burmeister: Thymic adult T-cell acute lymphoblastic leukemia stratified in standard- and high-risk group by aberrant HOX11L2 expression: experience of the German multicenter ALL study group. in Leukemia 2008 (PubMed)

More Antibodies against TLX1 Interaction Partners

Mouse (Murine) T-Cell Leukemia Homeobox 1 (TLX1) interaction partners

  1. Tlx1(CreER-Venus) mice represent a new tool for lineage tracing and conditional gene manipulation of spleen mesenchymal cells during morphogenesis.

  2. Hox11 genes are expressed in the connective tissue fibroblasts of the outer perichondrium, tendons and muscle connective tissue of the zeugopod region throughout all stages of development.

  3. Tlx1/3 and Ptf1a (show PTF1A Antibodies), the key transcription factors for fate determination of glutamatergic and GABAergic neurons in the dorsal spinal cord

  4. Results demonstrate that the transcriptional activity of HOX11 is regulated by phosphorylation of Thr247 in a cell cycle-specific manner and that this phosphorylation modulates the expression of the target gene, cyclin B1 (show CCNB1 Antibodies).

  5. Hox11 paralogous genes regulate wrist and ankle joint organization and are essential for establishing carpal and tarsal element boundary and maintaining their articulating surface tissue.

  6. Seven conserved Cdx (show CDX1 Antibodies) binding sites were found in the Hoxa 11 (show HOXA11 Antibodies) promoter, suggesting regulatory sites.

  7. dysregulated expression of a particular set of downstream target genes by DNA binding via the homeodomain is of central importance for leukemia initiation mediated by HOX11 homeodomain protein

  8. results have shown that the Hox10 (show VSX2 Antibodies) and Hox11 paralogous genes are global regulators of the lumbosacral region of the axial skeleton and are integral in patterning principal limb elements

  9. These studies establish a Pbx1 (show PBX1 Antibodies)-Hox11-dependent genetic and transcriptional pathway in spleen ontogeny.

  10. HOX11/TLX1 stem cells from the spleen of normal mice have been harvested to assist in both the treatment and cure at least two autoimmune diseases.

Human T-Cell Leukemia Homeobox 1 (TLX1) interaction partners

  1. The occurrence of G-quadruplex structures at the HOX11 breakpoint region explain its fragility during the t(10;14) translocation.

  2. these results place TLX1 and TLX3 (show TLX3 Antibodies) at the top of an oncogenic transcriptional network controlling leukemia development, and identify RUNX1 (show RUNX1 Antibodies) as a tumor-suppressor gene in T-ALL

  3. The cortical thymic maturation arrest in T-lineage Acute lymphoblastic leukemias (ALLs) that overexpress TLX1 or TLX3 (show TLX3 Antibodies) is due to binding of TLX1/TLX3 (show TLX3 Antibodies) to ETS1 (show ETS1 Antibodies).

  4. Suppression of TLX1 expression slowed the growth of TLX1 tumor cell lines. Suppression of TLX1 in vivo also transiently delayed leukemia progression.

  5. conclude that the TLX1/NOTCH (show NOTCH1 Antibodies)/MYC (show MYC Antibodies) network is a central determinant promoting the growth and survival of TLX1+ T-ALL cells. In addition, the TLX1/NOTCH (show NOTCH1 Antibodies)/MYC (show MYC Antibodies) transcriptional network coregulates genes involved in T cell development

  6. Transgenic expression of human TLX1 in mice induces T cell acute lymphoblastic leukemia with frequent deletions and mutations in Bcl11b (show BCL11B Antibodies).

  7. co-operation between TLX1 and MEIS proteins may have a significant role in T-cell leukemogenesis.

  8. A PBX2 (show PBX2 Antibodies) Regulatory Element PRE-1048 has been identified which contains a novel DNA-binding sequence and mediates significant activation of the HOX11 gene in K562 cells.

  9. Seven conserved Cdx (show CDX1 Antibodies) binding sites were found in the Hoxa 11 (show HOXA11 Antibodies) promoter, suggesting regulatory sites.

  10. Hox11 expression is linked to chromosomes 5 and 14 in T-cell malignancies in children.

Zebrafish T-Cell Leukemia Homeobox 1 (TLX1) interaction partners

  1. Detrmination site by nested polymerase chain reaction the integration sites in TLX1-immortalized hematopoietic cell lines.

  2. identification and expression patterns of three members of the zebrafish Tlx (show NR2E1 Antibodies) family

TLX1 Antigen Profile

Protein Summary

This gene encodes a nuclear transcription factor that belongs to the NK-linked or NK-like (NKL) subfamily of homeobox genes. The encoded protein is required for normal development of the spleen during embryogenesis. This protein is also involved in specification of neuronal cell fates. Ectopic expression of this gene due to chromosomal translocations is associated with certain T-cell acute lymphoblastic leukemias. Alternate splicing results in multiple transcript variants.

Gene names and symbols associated with TLX1

  • T cell leukemia, homeobox 1 (Tlx1) antibody
  • T-cell leukemia homeobox 1 (TLX1) antibody
  • T-cell leukemia homeobox 1 (tlx1) antibody
  • T-cell leukemia, homeobox 1 (Tlx1) antibody
  • T-cell leukemia, homeobox 1 (tlx1) antibody
  • Hox-11 antibody
  • hox11 antibody
  • RGD1563655 antibody
  • SI:dZ46P4.1 antibody
  • TCL3 antibody
  • Tlx-1 antibody
  • tlx1-a antibody
  • XHox11 antibody
  • XHox11L2 antibody
  • ztlx-1 antibody

Protein level used designations for TLX1

T-cell leukemia homeobox protein 1 , T-cell leukemia, homeobox 1 , homeobox TLX-1 , homeobox protein Hox-11 , T-cell leukemia/lymphoma protein 3 , homeo box-11 (T-cell leukemia-3 associated breakpoint, homologous to Drosophila Notch) , proto-oncogene TCL-3 , homeobox protein 11

GENE ID SPECIES
21908 Mus musculus
3195 Homo sapiens
373832 Xenopus laevis
395868 Gallus gallus
608311 Canis lupus familiaris
505304 Bos taurus
499361 Rattus norvegicus
266964 Danio rerio
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