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Acts as GTPase-activating protein for RAB27A (By similarity).. Additionally we are shipping TBC1 Domain Family, Member 10A Proteins (3) and many more products for this protein.
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EPI64, a candidate GAP that is specific for Rab27 (show RAB27A Antibodies).
Data suggest that EPI64A and B, which are ubiquitously expressed members of the EPI64 subfamily, inactivate Ras and certain Rabs at the periphery of cells.
EPI64 regulates membrane trafficking both by stabilizing Arf6 (show ARF6 Antibodies)-GTP (show AK3 Antibodies) and by inhibiting the recycling of membrane through the tubular endosome by decreasing Rab8a (show RAB8A Antibodies)-GTP (show AK3 Antibodies) levels.
analysis of recycling of the Ca2 (show CA2 Antibodies)+-activated K+ channel (show KCNC4 Antibodies), KCa2.3 (show KCNN3 Antibodies), is dependent upon RME-1 (show EHD1 Antibodies), Rab35 (show RAB35 Antibodies)/EPI64C (show TBC1D10C Antibodies), and an N-terminal domain
EPI64 is a GTPase-activating protein (show RASA1 Antibodies) specific for Rab27A (show RAB27A Antibodies)
These data reveal that microvilli have distinct cytoskeletal subdomains and that EPI64 regulates microvillar structure.
EPI64C and Rab35 regulate a recycling pathway in T cells and contribute to immunological synapse formation, most likely by participating in TCR transport to the immunological synapse
Acts as GTPase-activating protein for RAB27A (By similarity).
EBP50-PDX interactor of 64 kDa
, EBP50-PDZ interactor of 64 kD
, TBC1 domain family member 10A