Tankyrase, TRF1-Interacting Ankyrin-Related ADP-Ribose Polymerase 2 (TNKS2) ELISA Kits

Poly-ADP-ribosyltransferase involved in various processes such as Wnt signaling pathway, telomere length and vesicle trafficking. Additionally we are shipping Tankyrase, TRF1-Interacting Ankyrin-Related ADP-Ribose Polymerase 2 Antibodies (62) and Tankyrase, TRF1-Interacting Ankyrin-Related ADP-Ribose Polymerase 2 Proteins (4) and many more products for this protein.

list all ELISA KIts Gene Name GeneID UniProt
TNKS2 80351 Q9H2K2
TNKS2 74493 Q3UES3
Anti-Rat TNKS2 TNKS2 309512  
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Top Tankyrase, TRF1-Interacting Ankyrin-Related ADP-Ribose Polymerase 2 ELISA Kits at antibodies-online.com

Showing 6 out of 12 products:

Catalog No. Reactivity Sensitivity Range Images Quantity Supplier Delivery Price Details
Human 0.040 ng/mL 0.156-10 ng/mL 96 Tests Log in to see 15 to 17 Days
$908.41
Details
Chicken 0.094 ng/mL 0.156-10 ng/mL   96 Tests Log in to see 12 to 14 Days
$715.00
Details
Pig 0.094 ng/mL 0.156-10 ng/mL   96 Tests Log in to see 12 to 14 Days
$715.00
Details
Rabbit 37.5 pg/mL 62.5-4000 pg/mL   96 Tests Log in to see 12 to 14 Days
$715.00
Details
Monkey 0.094 ng/mL 0.156-10 ng/mL   96 Tests Log in to see 12 to 14 Days
$715.00
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Mouse
  96 Tests Log in to see 15 to 18 Days
$875.60
Details

More ELISA Kits for Tankyrase, TRF1-Interacting Ankyrin-Related ADP-Ribose Polymerase 2 Interaction Partners

Human Tankyrase, TRF1-Interacting Ankyrin-Related ADP-Ribose Polymerase 2 (TNKS2) interaction partners

  1. Polymerization is required for Tankyrase to drive beta-catenin (show CTNNB1 ELISA Kits)-dependent transcription. The polymeric state supports PARP (show COL11A2 ELISA Kits) activity and allows Tankyrase to effectively access destruction complexes through enabling avidity-dependent AXIN (show AXIN1 ELISA Kits) binding.

  2. These structural insights will be invaluable for the functional and biophysical characterization of TNKS1/2, including the role of TNKS oligomerization in protein poly(ADP-ribosyl)ation (PARylation) and PARylation-dependent ubiquitylation.

  3. High TNKS2 expression is associated with breast cancer.

  4. The tumor suppressive activity of miR (show MLXIP ELISA Kits)-490-3p is largely mediated through downregulation of TNKS2 and inactivation of beta-catenin (show CTNNB1 ELISA Kits) signaling. Thus, miR (show MLXIP ELISA Kits)-490-3p may represent a potential therapeutic target for triple-negative breast cancer.

  5. Data show that E7449 represents a dual Poly(ADP-ribose) Polymerase 1 (show PARP1 ELISA Kits)/2 and tankyrase 1 (show TNKS ELISA Kits)/2 inhibitor which has the advantage of targeting Wnt (show WNT2 ELISA Kits)/beta-catenin (show CTNNB1 ELISA Kits) signaling addicted tumors.

  6. Tankyrase inhibition is a potential therapeutic approach for treating a subgroup HCC (show FAM126A ELISA Kits) with aberrant WNT (show WNT2 ELISA Kits)/beta-catenin (show CTNNB1 ELISA Kits) signaling pathway.

  7. TNKS2 is recruited to DNA lesions by MDC1 (show MDC1 ELISA Kits) and promotes homologous recombination in response to DNA double strand breaks.

  8. The variability of genes encoding for TERF1 (show TERF1 ELISA Kits) and TNKS2 is important for keeping the integrity of the telomere structure and show a significant association with longevity.

  9. Studies show a significant interaction of IWR1 with acidic and polar residues (Asp (show ASIP ELISA Kits) and Tyr (show TYR ELISA Kits)) in the hydrophobic region at the induced pocket of TNKS1 (show TNKS ELISA Kits)/TNKS2. These two residues are the key for the mechanism of inhibition of TNKS (show TNKS ELISA Kits) proteins.

  10. Data indicate a basis for development of flavones as tankyrase inhibitors and suggest the development of other structurally related inhibitors.

Mouse (Murine) Tankyrase, TRF1-Interacting Ankyrin-Related ADP-Ribose Polymerase 2 (TNKS2) interaction partners

  1. Tank1 (show TNKS ELISA Kits)/Tank2 inhibition aggravates kidney injury in the absence of CD2AP (show Cd2ap ELISA Kits).

  2. a new function of RNF146 (show RNF146 ELISA Kits) and tankyrase in stabilizing the Crumbs complex through downregulation of AMOT (show AMOT ELISA Kits) proteins at the apical membrane, is reported.

  3. These structural insights will be invaluable for the functional and biophysical characterization of TNKS1/2, including the role of TNKS oligomerization in protein poly(ADP-ribosyl)ation (PARylation) and PARylation-dependent ubiquitylation.

  4. TNKS2 is required in insulin (show INS ELISA Kits)-stimulated glucose disposal.

  5. Study shows that TNKS2, regulates 3BP2 stability through ADP-ribosylation and subsequent ubiquitylation in osteoclasts; cherubism mutations uncouple 3BP2 from Tankyrase-mediated protein destruction.

  6. Data show that Tnks1 (show TNKS ELISA Kits) and 2 are broadly expressed during mouse development and are essential during kidney and lung development. In the kidney, blockage of tankyrase activity phenocopies the effect of blocking production of all Wnt (show WNT2 ELISA Kits) ligands.

  7. inactivation of tankyrase 2 does not result in the alteration in telomere length when monitored through multiple generations of breeding, tankyrase 2 functions in potentially telomerase-independent pathways to affect overall development and/or metabolism.

  8. Tnks2 has a role in normal growth and development but is not essential for telomere length maintenance or telomere capping in mice.

  9. tankyrase 2is essential but redundant for mouse embryonic development

Tankyrase, TRF1-Interacting Ankyrin-Related ADP-Ribose Polymerase 2 (TNKS2) Antigen Profile

Antigen Summary

Poly-ADP-ribosyltransferase involved in various processes such as Wnt signaling pathway, telomere length and vesicle trafficking. Acts as an activator of the Wnt signaling pathway by mediating poly-ADP-ribosylation of AXIN1 and AXIN2, 2 ribosylated target proteins are recognized by RNF146, which mediates their ubiquitination and subsequent degradation. Also mediates poly-ADP-ribosylation of BLZF1 and CASC3, followed by recruitment of RNF146 and subsequent ubiquitination. Mediates poly-ADP-ribosylation of TERF1, thereby contributing to the regulation of telomere length. May also regulate vesicle trafficking and modulate the subcellular distribution of SLC2A4/GLUT4-vesicles (By similarity).$.

Gene names and symbols associated with TNKS2

  • tankyrase, TRF1-interacting ankyrin-related ADP-ribose polymerase 2 (TNKS2) antibody
  • tankyrase, TRF1-interacting ankyrin-related ADP-ribose polymerase 2 (tnks2) antibody
  • tankyrase-2-like (LOC100855568) antibody
  • tankyrase, TRF1-interacting ankyrin-related ADP-ribose polymerase 2 (Tnks2) antibody
  • 5430432P15Rik antibody
  • AA517131 antibody
  • AI662480 antibody
  • ARTD6 antibody
  • PARP-5b antibody
  • PARP-5c antibody
  • PARP5B antibody
  • PARP5C antibody
  • pART6 antibody
  • Tank2 antibody
  • tankyrase-2 antibody
  • TNKL antibody
  • TNKS-2 antibody
  • TNKS2 antibody

Protein level used designations for TNKS2

tankyrase, TRF1-interacting ankyrin-related ADP-ribose polymerase 2 , tankyrase-2 , tankyrase-2-like , ADP-ribosyltransferase diphtheria toxin-like 6 , TNKS-2 , TRF1-interacting ankyrin-related ADP-ribose polymerase 2 , poly [ADP-ribose] polymerase 5B , tankyrase 2 , tankyrase II , tankyrase-like protein , tankyrase-related protein

GENE ID SPECIES
477767 Canis lupus familiaris
533901 Bos taurus
698050 Macaca mulatta
100061968 Equus caballus
100391147 Callithrix jacchus
100539557 Meleagris gallopavo
100567928 Anolis carolinensis
100591011 Nomascus leucogenys
100855568 Canis lupus familiaris
80351 Homo sapiens
74493 Mus musculus
309512 Rattus norvegicus
100154520 Sus scrofa
374253 Gallus gallus
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