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The protein encoded by TSPAN2 is a member of the transmembrane 4 superfamily, also known as the tetraspanin family. Additionally we are shipping Tetraspanin 2 Antibodies (85) and many more products for this protein.
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TSPAN2 may promote apoptosis of RNAKT-15 cells by regulating the JNK (show MAPK8 Proteins)/beta-catenin (show CTNNB1 Proteins) pathway in response to high glucose concentrations. Targeting TSPAN2 could be a potential therapeutic strategy to treat glucose toxicity-induced beta-cell failure.
A novel locus (G allele at rs12122341) at 1p13.2 near TSPAN2 that was associated with large artery atherosclerosis-related stroke.
Studies suggest that TSPAN2 may contribute to the early stages of the oligodendrocyte differentiation into myelin-forming glia. Furthermore, in human lung cancer, Tspan2 could be involved in the progression of the tumour metastasis by modulating cancer cell motility and invasion functions. [review]
TSPAN2 is identified as a factor responsible for invasion, motility, and metastasis.
the C-allele of rs2078371 near TSPAN-2 also reached genome-wide significance for association with migraine.
the activation of astrocytes and microglia was strongly enhanced in Tspan2(null) *Plp1 (show PLP1 Proteins)(null) double-mutants compared with either single-mutant
The protein encoded by this gene is a member of the transmembrane 4 superfamily, also known as the tetraspanin family. Most of these members are cell-surface proteins that are characterized by the presence of four hydrophobic domains. The proteins mediate signal transduction events that play a role in the regulation of cell development, activation, growth and motility.
, tetraspanin 2
, new EST tetraspan 3
, tetraspan NET-3
, tetraspan TM4SF
, tetraspanin 2 isoform