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The protein encoded by TSPAN7 is a member of the transmembrane 4 superfamily, also known as the tetraspanin family. Additionally we are shipping Tetraspanin 7 Antibodies (69) and Tetraspanin 7 Kits (5) and many more products for this protein.
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a yeast two-hybrid screen on a bovine brain cDNA expression library and identified the transmembrane protein tetraspanin-7 (CD231), as a PrP(C (show PRNP Proteins)) interacting protein.
These results disclosed a previously uncharacterized role of TSPAN7 in the regulation of the expression and functional activity of DRD2 (show DRD2 Proteins) by postendocytic trafficking.
The role of TSPAN7 in immune system response to HIV-1 is reviewed. TSPAN7 appears to be a positive regulator of actin nucleation and stabilization, through the ARP2/3 complex. By doing so, TSPAN7 limits HIV-1 endocytosis and maintains viral particles on actin-rich dendrites for an efficient transfer toward T lymphocytes.
Elevated TSPAN7 may be associated with better outcomes for multiple myeloma patients.
Loss of TSPAN7 is associated with metastasis in clear-cell renal cell carcinoma (show MOK Proteins).
This study identified that TSPAN7 as a key molecule for the functional maturation of dendritic spines via PICK1 (show PICK1 Proteins) and ampa (show GRIA3 Proteins) receptor trafficking.
TM4SF2 was identified as a putative antigenic target in Wegener's granulomatosis
Studies indicate that The thymus leukemia (TL) antigen and CD8alphaalpha are interacting surface molecules that are expressed at the frontline of the mucosal immune system.
The interaction of VP26 with tetraspanin-7 plays an essential role in normal HSV-1 replication.
coding mutations in TSPAN7 are not associated with our cohort of autism patients
Our results suggest that Tspan7 plays an important role in cytoskeletal organization required for the bone-resorbing function of osteoclasts by regulating signaling to Src (show SRC Proteins), Pyk2 (show PTK2B Proteins), and microtubules.
DC-STAMP, Siglec-15 (show SIGLEC15 Proteins), Tspan7 and Mst1r (show MST1R Proteins) expression was downregulated by docosahexaenoic acid, but not eicosapentaenoic acid during osteoclastogenesis in vitro.
The protein encoded by this gene is a member of the transmembrane 4 superfamily, also known as the tetraspanin family. Most of these members are cell-surface proteins that are characterized by the presence of four hydrophobic domains. The proteins mediate signal transduction events that play a role in the regulation of cell development, activation, growth and motility. This encoded protein is a cell surface glycoprotein and may have a role in the control of neurite outgrowth. It is known to complex with integrins. This gene is associated with X-linked mental retardation and neuropsychiatric diseases such as Huntington's chorea, fragile X syndrome and myotonic dystrophy.
, transmembrane 4 superfamily member 2
, tetraspanin 7
, CD231 antigen
, T-cell acute lymphoblastic leukemia associated antigen 1
, T-cell acute lymphoblastic leukemia-associated antigen 1
, cell surface glycoprotein A15
, membrane component chromosome X surface marker 1
, membrane component, X chromosome, surface marker 1
, tetraspanin protein
, transmembrane 4 superfamily 2b
, transmembrane protein A15
, TALLA homolog
, Transmembrane 4, superfamily member 2 (cell surface glycoprotein A15)
, neuroprotective protein 5