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Involved in biosynthesis of the thiamine precursor thiazole.
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blk1-R mutants have defects in vegetative shoot meristem maintenance, leaf blade development, and reduced inflorescence development.
Involved in biosynthesis of the thiamine precursor thiazole. Catalyzes the conversion of NAD and glycine to adenosine diphosphate 5-(2-hydroxyethyl)-4-methylthiazole-2-carboxylic acid (ADT), an adenylated thiazole intermediate. The reaction includes an iron-dependent sulfide transfer from a conserved cysteine residue of the protein to a thiazole intermediate. The enzyme can only undergo a single turnover, which suggests it is a suicide enzyme. May have additional roles in adaptation to various stress conditions and in DNA damage tolerance.
, thiamine biosynthetic enzyme
, thiamine thiazole synthase 2, chloroplastic
, thiazole biosynthetic enzyme 1-2, chloroplastic
, thiazole biosynthetic enzyme 2