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TFPI encodes a protease inhibitor that regulates the tissue factor (TF)-dependent pathway of blood coagulation. Additionally we are shipping TFPI Antibodies (177) and TFPI Kits (65) and many more products for this protein.
Showing 10 out of 33 products:
Human TFPI Protein expressed in Human Cells - ABIN2003062
Broze, Warren, Novotny, Higuchi, Girard, Miletich: The lipoprotein-associated coagulation inhibitor that inhibits the factor VII-tissue factor complex also inhibits factor Xa: insight into its possible mechanism of action. in Blood 1988
Show all 5 references for ABIN2003062
Mouse (Murine) TFPI Protein expressed in Human Cells - ABIN2007377
Ruci?ska, Gacko, Skrzydlewski: Tissue factor pathway inhibitor (TFPI). in Roczniki Akademii Medycznej w Bia?ymstoku (1995) 1997
Show all 4 references for ABIN2007377
Human TFPI Protein expressed in Escherichia coli (E. coli) - ABIN1047744
Wun, Kretzmer, Girard, Miletich, Broze: Cloning and characterization of a cDNA coding for the lipoprotein-associated coagulation inhibitor shows that it consists of three tandem Kunitz-type inhibitory domains. in The Journal of biological chemistry 1988
Show all 3 references for ABIN1047744
Human TFPI Protein expressed in HEK-293 Cells - ABIN2181804
Bajaj, Mehta, Kashyap, Pushker, Lohia, Chawla, Ghose: Clinical and pathologic profile of angiomyxomas of the orbit. in Ophthalmic plastic and reconstructive surgery 2011
Results suggest that endothelial cell-anchored TFPI controls lung tumor metastasis, and does so largely through the inhibition of local TF-induced thrombin (show F2 Proteins) generation and the regulation of the lung microenvironment in mice.
Data argue against an important role for endogenous TFPI in the antibacterial, inflammatory and procoagulant response during pneumococcal pneumonia.
TFPI has an anti-proliferative role in TNF-alpha (show TNF Proteins) stimulated-VSMCs at least partly by interfering with the MCP-3 (show CCL7 Proteins)/CCR2 (show CCR2 Proteins) pathway and then via suppression of the ERK1/2 and PI3K/AKT (show AKT1 Proteins) signaling pathways
Results demonstrate that TFPI physiologically modulates thrombin (show F2 Proteins)-dependent platelet activation in a manner that is required for successful embryonic development
Tissue factor (show F3 Proteins) plays a hitherto unreported role in the generation of macrophage migratory inhibitory factor by vascular smooth muscle cells in atherosclerosis-prone ApoE (show APOE Proteins)(-/-) mice.
The increased plasmin (show PLG Proteins) generation during the early stages of sepsis could cleave/inactivate TFPI and thus lead to thrombotic complications.
structural features within residues of the 39-loop contribute to the resistance of FIXa (show ETFB Proteins) to inhibition by plasma inhibitors ZPI (show SERPINA10 Proteins) and TFPI.
PAK1 (show PAK1 Proteins) negatively regulates the expression of TFPI and additionally contributes to increased TF activity.
Murine models of combined TFPI and factor VIII deficiency were used to examine the impact of TFPI deficiency on bleeding and clotting in hemophilia
Data demonstrate an inhibitory role for TFPI in angiogenesis that is, in part, mediated through peptides within its carboxyl terminus.
HIF-1alpha (show HIF1A Proteins) is involved in the transcriptional regulation of the TFPI gene, and suggests that a hypoxic microenvironment inside a breast tumor may induce a procoagulant state in breast cancer patients.
ERalpha (show ESR1 Proteins) can interact with all three ERE half-sites in the TFPI 5'-flanking region.
rs5940 and rs7586970 moderate TFPI plasma levels and are candidate risk factors for thrombosis, but the regulation of TFPI plasma levels involves genetic factors beyond the TFPI gene. Review.
Tissue factor pathway inhibitor activity and APC (show APC Proteins) resistance are related to coronary heart disease risk in women, but may not explain the increased CHD (show CHDH Proteins) risk due to estrogen plus progestin therapy.
coagulation system, TFPI play an important role in the pathogenesis of CRSwNP.
A significant degradation of TFPI was induced by ROS (show ROS1 Proteins) exposure, resulting in a decreased ability to bind FXa (show F10 Proteins). ROS (show ROS1 Proteins) induce a procoagulant state in endothelial cells by altering TFPI structure, resulting in inhibition of TFPI binding to Factor Xa (show F10 Proteins)
TNFalpha (show TNF Proteins) and Stx-1 (show STX1A Proteins) compared to TNFalpha (show TNF Proteins) alone leads to an increase in procoagulant TF on endothelial cells, which is explained by a significant decrease in TFPI not co-localized with TF and not to an increase in TF not co-localized with TFPI
Direct inhibition of FXa (show F10 Proteins) by TFPIalpha inhibits thrombin (show F2 Proteins) generation and contributes to the downregulation of coagulation.
Tissue factor pathway inhibitor-2 (show TFPI2 Proteins) gene polymorphisms were associated with coronary atherosclerosis in the Chinese population
Syndecan-3 (show SDC3 Proteins) and TFPI colocalize on the surface of endothelial-, smooth muscle-, and cancer cells
Upregulated TF expression and increased plasma TF level during reperfusion period, reduced plasma TFPI-1 level during reperfusion period.
This gene encodes a protease inhibitor that regulates the tissue factor (TF)-dependent pathway of blood coagulation. The coagulation process initiates with the formation of a factor VIIa-TF complex, which proteolytically activates additional proteases (factors IX and X) and ultimately leads to the formation of a fibrin clot. The product of this gene inhibits the activated factor X and VIIa-TF proteases in an autoregulatory loop. The encoded protein is glycosylated and predominantly found in the vascular endothelium and plasma in both free forms and complexed with plasma lipoproteins. Several alternatively spliced transcript variants of this gene have been described, but the full-length nature of some of these variants has not been confirmed.
extrinsic pathway inhibitor
, lipoprotein-associated coagulation inhibitor
, uncharacterized protein LOC100155068
, tissue factor pathway inhibitor