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Titin-Cap (Telethonin) Proteins (TCAP)

Sarcomere assembly is regulated by the muscle protein titin. Additionally we are shipping TCAP Antibodies (29) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
TCAP 8557 O15273
TCAP 21393 O70548
Rat TCAP TCAP 688173  
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Top TCAP Proteins at antibodies-online.com

Showing 5 out of 7 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
HOST_Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
HOST_Escherichia coli (E. coli) Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
HOST_Wheat germ Human GST tag 10 μg Log in to see 9 Days
$405.71
Details
Yeast Cow His tag   1 mg Log in to see 56 to 66 Days
$2,379.67
Details
HOST_Escherichia coli (E. coli) Human Un-conjugated   50 μg Log in to see 9 to 11 Days
$229.85
Details

TCAP Proteins by Origin and Source

Origin Expressed in Conjugate
Human ,
,
Mouse (Murine)

More Proteins for Titin-Cap (Telethonin) (TCAP) Interaction Partners

Zebrafish Titin-Cap (Telethonin) (TCAP) interaction partners

  1. Data show show that tcap is functionally conserved and reduction of Tcap resulted in muscular dystrophy-like phenotypes including deformed muscle structure and impaired swimming ability.

Xenopus laevis Titin-Cap (Telethonin) (TCAP) interaction partners

  1. Distinct roles for telethonin N-versus C-terminus in sarcomere assembly and maintenance.

Human Titin-Cap (Telethonin) (TCAP) interaction partners

  1. Data indicate LGMD2G protein TCAP association with limb girdle muscular dystrophy 2G (LGMD2G).

  2. Report TCAP mutations in dilated cardiomyopathy.

  3. cardiac telethonin is constitutively bis (show BAG3 Proteins)-phosphorylated and suggest that such phosphorylation is critical for normal telethonin function, which may include maintenance of transverse tubule organization and intracellular Ca(2 (show CA2 Proteins)+) transients.

  4. This study identified no pathogenic mutations in BAG3 (show BAG3 Proteins), MATR3 (show MATR3 Proteins), PTRF (show PTRF Proteins) or TCAP in Australian muscular dystrophy.

  5. reduced expression of dystrophin (show DMD Proteins) and titin (show TTN Proteins) is associated with the pathophysiology of dilated cardiomyopathy, and TNF-alpha (show TNF Proteins) may modulate the expression of these proteins via NF-kappaB (show NFKB1 Proteins) pathway.

  6. Genetic studies of tcap in zebrafish suggested that pathogenesis in LGMD2G is due to a disruption of sarcomere-T-tubular interaction, but not of sarcomere assembly per se.

  7. review of telethonin and other new proteins of the Z-disc of skeletal muscle

  8. telethonin protein levels seems to be at least in part regulated by neuronal activity and is thus linked to the dynamic control of myofibrillogenesis and muscle turnover in human skeletal muscle.

  9. telethonin may play a role in linking titin (show TTN Proteins) filaments at the Z-disk periphery

  10. TCAP mutations identified which are associated with hypertrophic cardiomyopathy.

Mouse (Murine) Titin-Cap (Telethonin) (TCAP) interaction partners

  1. cardiac telethonin is constitutively bis (show BAG3 Proteins)-phosphorylated and suggest that such phosphorylation is critical for normal telethonin function, which may include maintenance of transverse tubule organization and intracellular Ca(2 (show CA2 Proteins)+) transients.

  2. Tcap is a critical, load-sensitive regulator of t-tubule structure and function.

  3. Telethonin knockout mice develop heart failure following biomechanical stress, owing at least in part to apoptosis of cardiomyocytes, an effect that may also play a role in human heart failure.

  4. Whereas both promotor E boxes in Tcap are required for full activation by MyoD (show MYOD1 Proteins) or myogenin (show MYOG Proteins) in NIH3T3 cells, the promoter proximal E box has a greater contribution to activation in C2C12 cells and to activation by MyoD (show MYOD1 Proteins) in NIH3T3 cells.

  5. Findings suggest that TCAP knockdown with RNA interference alters normal muscle cell differentiation.

Pig (Porcine) Titin-Cap (Telethonin) (TCAP) interaction partners

  1. TCAP promoter can be activated by MyoD (show MYOD1 Proteins), MyoG (show MYOG Proteins) and MEF2 (show MYEF2 Proteins) in myotubes, which indicated that TCAP may play a role in the regulation of skeletal muscle development.

TCAP Protein Profile

Protein Summary

Sarcomere assembly is regulated by the muscle protein titin. Titin is a giant elastic protein with kinase activity that extends half the length of a sarcomere. It serves as a scaffold to which myofibrils and other muscle related proteins are attached. This gene encodes a protein found in striated and cardiac muscle that binds to the titin Z1-Z2 domains and is a substrate of titin kinase, interactions thought to be critical to sarcomere assembly. Mutations in this gene are associated with limb-girdle muscular dystrophy type 2G.

Gene names and symbols associated with Titin-Cap (Telethonin) Proteins (TCAP)

  • titin-cap (telethonin) (TCAP)
  • titin-cap (telethonin) (tcap)
  • titin-cap (TCAP)
  • titin-cap (Tcap)
  • AI503981 protein
  • AJ223855 protein
  • CMD1N protein
  • LGMD2G protein
  • T-cap protein
  • TCAP protein
  • TELE protein
  • telethonin protein

Protein level used designations for Titin-Cap (Telethonin) Proteins (TCAP)

titin-cap (telethonin) , 19 kDa sarcomeric protein , limb girdle muscular dystrophy 2G (autosomal recessive) , telethonin , titin cap protein , titin-cap protein

GENE ID SPECIES
454633 Pan troglodytes
556258 Danio rerio
697327 Macaca mulatta
100380097 Xenopus (Silurana) tropicalis
100381005 Xenopus laevis
8557 Homo sapiens
608508 Canis lupus familiaris
21393 Mus musculus
688173 Rattus norvegicus
100271745 Sus scrofa
513257 Bos taurus
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