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anti-Topoisomerase (DNA) II beta 180kDa (TOP2B) Antibodies

TOP2B encodes a DNA topoisomerase, an enzyme that controls and alters the topologic states of DNA during transcription. Additionally we are shipping Topoisomerase (DNA) II beta 180kDa Kits (11) and Topoisomerase (DNA) II beta 180kDa Proteins (5) and many more products for this protein.

list all antibodies Gene Name GeneID UniProt
TOP2B 21974 Q64511
TOP2B 361100  
TOP2B 7155 Q02880
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Top anti-Topoisomerase (DNA) II beta 180kDa Antibodies at antibodies-online.com

Showing 10 out of 53 products:

Catalog No. Reactivity Host Conjugate Application Images Quantity Supplier Delivery Price Details
Human Rabbit Un-conjugated WB WB Suggested Anti-TOP2B Antibody Titration: 0.2-1 ug/mlELISA Titer: 1:1562500Positive Control: Jurkat cell lysate WB Suggested Anti-TOP2B  Antibody Titration: 0.2-1 µg/mL ELISA Titer: 1:1562500  Positive Control: Jurkat cell lysate  TOP2B is supported by BioGPS gene expression data to be expressed in Jurkat 100 μL Log in to see 2 to 3 Days
$289.00
Details
Human Mouse Un-conjugated BI, IF, WB Western blot analysis of Topo IIbeta on a Jurkat lysate. Lane 1: 1:1000, lane 2: 1:2000, lane 3: 1:4000 dilution of the Topo IIbeta antibody. Immunofluorescent staining of A549 cells. Cells were seeded in a 96 well imaging plate at ~ 10 000 cells per well. After overnight incubation, cells were stained using the methanol fix/perm protocol and the anti-Topisomerase IIbeta antibody. The second step reagent was FITC goat anti mouse Ig. The image was taken on a Pathway 850 imager using a 20x objective. This antibody also stained HeLa and U2OS cells and can be used with either fix/perm protocol. 50 μg Log in to see 5 to 6 Days
$205.42
Details
Human Rabbit Un-conjugated IHC (p), WB 0.1 mg Log in to see 6 to 8 Days
$390.50
Details
Human Rabbit Un-conjugated IHC, ELISA, WB Western blot analysis of extracts from Jurkat cells, using TOP2B Antibody. The lane on the right is treated with the synthesized peptide. Immunohistochemistry analysis of paraffin-embedded human lung carcinoma tissue, using TOP2B Antibody. The picture on the right is treated with the synthesized peptide. 100 μg Log in to see 2 to 3 Days
$302.50
Details
Human Rabbit Un-conjugated IP, IHC (p), WB IP Image Topoisomerase II beta antibody immunoprecipitates Topoisomerase II beta protein in IP experiments. IP Sample: HeLa whole cell lysate/extract A. 40 μg HeLa whole cell lysate/extract B. Control with 2 μg of preimmune rabbit IgG C. Immunoprecipitation of Topoisomerase II beta protein by 2 μg of Topoisomerase II beta antibody , 5% SDS-PAGE The immunoprecipitated Topoisomerase II beta protein was detected by Topoisomerase II beta antibody , diluted at 1:1000. EasyBlot anti-rabbit IgG  was used as a secondary reagent. WB Image Sample (30 ug of whole cell lysate) A: Jurkat 5% SDS PAGE antibody diluted at 1:3000 100 μL Log in to see 2 to 3 Days
$358.60
Details
Human Rabbit Un-conjugated ELISA, WB 100 μL Log in to see 8 to 10 Days
$478.50
Details
Human Rabbit Un-conjugated WB 50 μg Log in to see 8 to 10 Days
$551.83
Details
Human Rabbit Un-conjugated ELISA, WB 100 μL Log in to see 8 to 10 Days
$390.50
Details
Human Rabbit Un-conjugated IHC, ELISA 100 μL Log in to see 8 to 10 Days
$390.50
Details
Human Rabbit Un-conjugated IHC, ELISA, WB The TOP2B Antibody is used in Western blot to detect TOP2B in HeLa cell lysates. 0.1 mg Log in to see 2 to 6 Days
$403.70
Details

TOP2B Antibodies by Reactivity, Application, Clonality and Conjugate

Attributes Applications Host Clonality Conjugate
Mouse (Murine) ,


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Rat (Rattus)


Human , , , ,
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Top referenced anti-Topoisomerase (DNA) II beta 180kDa Antibodies

  1. Human Monoclonal TOP2B Primary Antibody for BI, IF - ABIN968561 : Brown, Holden, Rahn, Perkins: Immunohistochemical staining for DNA topoisomerase IIa in Hodgkin's disease. in American journal of clinical pathology 1998 (PubMed)
    Show all 5 references for ABIN968561

  2. Human Polyclonal TOP2B Primary Antibody for WB - ABIN2780351 : McNamara, Wang, Hanna, Miller: Topoisomerase IIbeta negatively modulates retinoic acid receptor alpha function: a novel mechanism of retinoic acid resistance. in Molecular and cellular biology 2008 (PubMed)

More Antibodies against Topoisomerase (DNA) II beta 180kDa Interaction Partners

Mouse (Murine) Topoisomerase (DNA) II beta 180kDa (TOP2B) interaction partners

  1. TOP2beta as a factor involved in regulating granulosa cell genomic integrity and follicle atresia.

  2. Results identified topoisomerase IIbeta (Top2beta) as a novel determinant for camptothecin sensitivity.

  3. Top IIbeta might be a down-stream target of Nurr1 (show NR4A2 Antibodies), which might influence the processes of axon genesis in dopaminergic neurons via the regulation of TOP IIbeta expression.

  4. Findings suggest a chromatin-based targeting of Top2beta to regulatory regions in the genome to govern the transcriptional program associated with neuronal differentiation and longevity.

  5. Data suggest that activity of TOP2B in elongating spermatids is strongly inhibited by PARP1 (show PARP1 Antibodies) and PARP2 (show PARP2 Antibodies), and this is in turn counteracted by the PAR (show AFG3L2 Antibodies)-degrading activity of PAR (show AFG3L2 Antibodies) glycohydrolase.

  6. proteasomal degradation of TOP2beta induced by the TOP2-DNA covalent complex or the TOP2 circular clamp is due to transcriptional arrest but not DNA damage

  7. DNA topoisomerase II beta deficiency severely affects cerebral cortex stratification: no subplate is discernible, and neurons born at later stages of corticogenesis fail to migrate to the superficial layers.

  8. A nuclear matrix-associated (show SMARCA5 Antibodies) topoisomerase IIB (TOP2B) interacting with an extracellular Mn2+/Ca2 (show CA2 Antibodies)+-dependent nuclease (show DCLRE1C Antibodies) cleaves sperm DNA into loop-sized fragments.

  9. These results suggest that the defect in establishing neuromuscular junctions in top2beta knockout mice could be due to the lack of TopIIbeta-mediated neurite outgrowth.

  10. VP-16-induced carcinogenesis involves mainly the beta rather than the alpha isozyme of Top2 (show TOP2 Antibodies); VP-16-induced DNA sequence rearrangements and double-strand breaks are found to be Top2beta-dependent

Human Topoisomerase (DNA) II beta 180kDa (TOP2B) interaction partners

  1. during early development, TOP2A (show TOP2A Antibodies) is likely to have a role in cell proliferation, whereas TOP2B is expressed in post-mitotic cells and may be important in controlling expression of long genes even at this early stage.

  2. Cinobufacini inhibited the proliferation of the HepG-2 cells induced apoptosis in a dose- and time-dependent manner and downregulated the mRNA and protein expression levels of TOPO I (show TOP1 Antibodies) and TOPO II (show TOP2 Antibodies)

  3. A direct interaction between Ku70 (show XRCC6 Antibodies)/86 and BRG1 (show SMARCA4 Antibodies) brings together SWI (show SMARCA1 Antibodies)/SNF (show SNRPA Antibodies) remodeling capabilities and TOP2beta activity to enhance the transcriptional response to hormone stimulation.

  4. Human cytomegalovirus IE1 exon 4 interacts with Topoisomerase IIbeta (TOPOIIbeta), whose activity is required for viral genome persistence and maintenance via binding to a cis (show CISH Antibodies)-acting viral maintenance element.

  5. Proteolytic degradation of Top2 (show TOP2A Antibodies) enables the processing of Top2 (show TOP2A Antibodies).DNA and Top2 (show TOP2A Antibodies).RNA covalent complexes by TDP2 (show TDP2 Antibodies).

  6. There is an association between chemosensitivity and Pgp (show PGPEP1 Antibodies), GST-pi (show GSTP1 Antibodies) and Topo II (show TOP2 Antibodies) expression in gastric cancer.

  7. Top2beta-DNA cleavage complexes arrest transcription elongation and induce a proteasomal degradation of Top2beta on DNA.

  8. Overexpression of Lewis(y) antigen confers cell adhesion-mediated drug resistance to apoptosis in ovarian cancer cells by the upregulation of Topo-I (show TOP1 Antibodies) and Topo-II beta.

  9. Tyrosine 656 in topoisomerase II beta is important for the catalytic activity of the enzyme.

  10. Data show significant associations between SNPs in RARA (show RARA Antibodies), RARB (show RARB Antibodies), TOP2B and RARG (show RARG Antibodies), RXRA (show RXRA Antibodies), TLR3 (show TLR3 Antibodies), TRIM5 (show TRIM5 Antibodies) and RIG-I (show DDX58 Antibodies) genes and rubella virus-specific cytokine immune responses.

Topoisomerase (DNA) II beta 180kDa (TOP2B) Antigen Profile

Protein Summary

This gene encodes a DNA topoisomerase, an enzyme that controls and alters the topologic states of DNA during transcription. This nuclear enzyme is involved in processes such as chromosome condensation, chromatid separation, and the relief of torsional stress that occurs during DNA transcription and replication. It catalyzes the transient breaking and rejoining of two strands of duplex DNA which allows the strands to pass through one another, thus altering the topology of DNA. Two forms of this enzyme exist as likely products of a gene duplication event. The gene encoding this form, beta, is localized to chromosome 3 and the alpha form is localized to chromosome 17. The gene encoding this enzyme functions as the target for several anticancer agents and a variety of mutations in this gene have been associated with the development of drug resistance. Reduced activity of this enzyme may also play a role in ataxia-telangiectasia. Alternative splicing of this gene results in two transcript variants\; however, the second variant has not yet been fully described.

Gene names and symbols associated with TOP2B

  • topoisomerase (DNA) II beta 180kDa (TOP2B) antibody
  • topoisomerase (DNA) II beta (Top2b) antibody
  • D230016L12Rik antibody
  • Top-2 antibody
  • TOP2B antibody
  • top2beta antibody
  • TOPIIB antibody

Protein level used designations for TOP2B

topoisomerase (DNA) II beta 180kDa , DNA topoisomerase II, beta isozyme , DNA topoisomerase 2-beta , topoisomerase II beta , DNA topoisomerase II beta , DNA topoisomerase II, 180 kD , U937 associated antigen , antigen MLAA-44 , topo II beta , topoisomerase IIb , DNA topoisomeraseII_beta , topoisomerase II beta-2

GENE ID SPECIES
460232 Pan troglodytes
21974 Mus musculus
361100 Rattus norvegicus
7155 Homo sapiens
395966 Gallus gallus
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