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TOP3B encodes a DNA topoisomerase, an enzyme that controls and alters the topologic states of DNA during transcription. Additionally we are shipping TOP3B Proteins (3) and many more products for this protein.
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Human Polyclonal TOP3B Primary Antibody for EIA, WB - ABIN955293
Oliveira-Costa, Zanetti, Oliveira, Soares, Ramalho, Silva Ramalho, Garcia, Ribeiro-Silva: Significance of topoisomerase IIIβ expression in breast ductal carcinomas: strong associations with disease-specific survival and metastasis. in Human pathology 2010
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TOP3B promotes transcription, protects against DNA damage, and reduces the frequency of chromosomal translocations.
the positive regulatory region including the 5'GGAACC3' core element is essential for efficient expression of the DNA topoisomerase III beta gene
DNA topoisomerase III beta has a role in infertility and aneuploidy
This gene encodes a DNA topoisomerase, an enzyme that controls and alters the topologic states of DNA during transcription. This enzyme catalyzes the transient breaking and rejoining of a single strand of DNA which allows the strands to pass through one another, thus relaxing the supercoils and altering the topology of DNA. The enzyme interacts with DNA helicase SGS1 and plays a role in DNA recombination, cellular aging and maintenance of genome stability. Alternative splicing of the C-terminus of this gene results in three transcript variants which have distinct tissue specificity\; however, not all variants have been fully described.
DNA topoisomerase 3-beta-1
, DNA topoisomerase III beta-1
, topoisomerase III beta
, Topo III beta