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anti-Transcription Factor A, Mitochondrial (TFAM) Antibodies

TFAM encodes a key mitochondrial transcription factor containing two high mobility group motifs. Additionally we are shipping TFAM Proteins (12) and TFAM Kits (7) and many more products for this protein.

list all antibodies Gene Name GeneID UniProt
TFAM 7019 Q00059
TFAM 21780 P40630
TFAM 83474 Q91ZW1
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Top anti-TFAM Antibodies at antibodies-online.com

Showing 10 out of 138 products:

Catalog No. Reactivity Host Conjugate Application Images Quantity Supplier Delivery Price Details
Cow Rabbit Un-conjugated WB WB Suggested Anti-TFAM Antibody Titration: 0.2-1 ug/mlELISA Titer: 1:1562500Positive Control: Jurkat cell lysate 100 μL Log in to see 2 to 3 Days
$289.00
Details
Cow Rabbit Un-conjugated IHC, WB WB Suggested Anti-Tfam Antibody Titration: 0.2-1 ug/mlPositive Control: SP2/0 cell lysate 100 μL Log in to see 2 to 3 Days
$289.00
Details
Mouse Rabbit Un-conjugated WB WB Suggested Anti-TFAM Antibody Titration: 0.2-1 ug/mlELISA Titer: 1:62500Positive Control: NIH/3T3 cell lysate 100 μL Log in to see 2 to 3 Days
$289.00
Details
Human Rabbit Un-conjugated FACS, IF, IHC (p), WB TFAM antibody (C-term)  immunohistochemistry analysis in formalin fixed and paraffin embedded human testis carcinoma followed by peroxidase conjugation of the secondary antibody and DAB staining.  This data demonstrates the use of the TFAM antibody (C-term) for immunohistochemistry.  Clinical relevance has not been evaluated. TFAM Antibody (C-term)  flow cytometric analysis of K562 cells (right histogram) compared to a negative control cell (left histogram).FITC-conjugated goat-anti-rabbit secondary antibodies were used for the analysis. 400 μL Log in to see 10 to 11 Days
$324.50
Details
Rat Rabbit Un-conjugated WB 100 μg Log in to see 2 to 3 Days
$283.50
Details
Human Rabbit Un-conjugated EIA, FACS, IF, IHC (p), WB TFAM Antibody (C-term) flow cytometric analysis of K562 cells (right histogram) compared to a negative control cell (left histogram). FITC-conjugated goat-anti-rabbit secondary antibodies were used for the analysis. Confocal immunofluorescent analysis of TFAM Antibody (C-term) with Hela cell followed by Alexa Fluor 488-conjugated goat anti-rabbit lgG (green). DAPI was used to stain the cell nuclear (blue). 0.4 mL Log in to see 6 to 8 Days
$401.50
Details
Human Rabbit Un-conjugated IF, IHC, ELISA Immunohistochemistry analysis of paraffin-embedded human liver carcinoma tissue, using TFAM Antibody. The picture on the right is treated with the synthesized peptide. Immunofluorescence analysis of HepG2 cells, using TFAM Antibody. The picture on the right is treated with the synthesized peptide. 100 μg Log in to see 2 to 3 Days
$302.50
Details
Human Rabbit Un-conjugated IHC, WB WB Suggested Anti-Tfam Antibody Titration: 0.2-1 ug/mlELISA Titer: 1:312500Positive Control: Mouse Muscle Immunohistochemistry with Placenta tissue at an antibody concentration of 5µg/ml using anti-Tfam antibody (ARP58723_P050) 100 μL Log in to see 2 to 3 Days
$289.00
Details
Human Rabbit Un-conjugated WB WB Suggested Anti-Tfam Antibody Titration: 0.2-1 ug/mlELISA Titer: 1:1562500Positive Control: Mouse Muscle 100 μL Log in to see 2 to 3 Days
$289.00
Details
Human Rabbit Un-conjugated IHC (p), WB Anti- mtTFA Picoband antibody,IHC(P) IHC(P): Human Lung Cancer Tissue 100 μg Log in to see 4 to 6 Days
$240.00
Details

TFAM Antibodies by Reactivity, Application, Clonality and Conjugate

Attributes Applications Host Clonality Conjugate
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Top referenced anti-TFAM Antibodies

  1. Cow (Bovine) Polyclonal TFAM Primary Antibody for WB - ABIN2777277 : Shi, Burkart, Nicoloro, Czech, Straubhaar, Corvera: Paradoxical effect of mitochondrial respiratory chain impairment on insulin signaling and glucose transport in adipose cells. in The Journal of biological chemistry 2008 (PubMed)
    Show all 7 references for ABIN2777277

  2. Human Polyclonal TFAM Primary Antibody for EIA, FACS - ABIN955168 : Corneveaux, Myers, Allen, Pruzin, Ramirez, Engel, Nalls, Chen, Lee, Chewning, Villa, Meechoovet, Gerber, Frost, Benson, OReilly, Chibnik, Shulman, Singleton, Craig, Van Keuren-Jensen, Dunckley, Bennett, De Jager, Heward, Hardy, Reiman, Huentelman: Association of CR1, CLU and PICALM with Alzheimer's disease in a cohort of clinically characterized and neuropathologically verified individuals. in Human molecular genetics 2010 (PubMed)
    Show all 2 references for ABIN955168

  3. Human Polyclonal TFAM Primary Antibody for IF, IHC - ABIN1533816 : Parisi, Clayton: Similarity of human mitochondrial transcription factor 1 to high mobility group proteins. in Science (New York, N.Y.) 1991 (PubMed)

  4. Rat (Rattus) Polyclonal TFAM Primary Antibody for WB - ABIN411602 : Arduini, Serviddio, Escobar, Tormos, Bellanti, Viña, Monsalve, Sastre: Mitochondrial biogenesis fails in secondary biliary cirrhosis in rats leading to mitochondrial DNA depletion and deletions. in American journal of physiology. Gastrointestinal and liver physiology 2011 (PubMed)

  5. Human Polyclonal TFAM Primary Antibody for FACS, IF - ABIN654229 : Shulman, Chibnik, Aubin, Schneider, Bennett, De Jager: Intermediate phenotypes identify divergent pathways to Alzheimer's disease. in PLoS ONE 2010 (PubMed)

  6. Cow (Bovine) Polyclonal TFAM Primary Antibody for IHC, WB - ABIN2779903 : Noack, Bednarek, Heidler, Ladig, Holtz, Szibor: TFAM-dependent and independent dynamics of mtDNA levels in C2C12 myoblasts caused by redox stress. in Biochimica et biophysica acta 2006 (PubMed)

More Antibodies against TFAM Interaction Partners

Human Transcription Factor A, Mitochondrial (TFAM) interaction partners

  1. Results showed that TFAM formed oligomers in mitochondria by in situ chemical cross-linking and suggested the importance of the dimerization of TFAM molecules in the distribution of mtDNA in cells.

  2. Report failed upregulation of TFAM protein and mitochondrial DNA in oxidatively deficient fibers in skeletal muscle of chronic obstructive pulmonary disease patients.

  3. Data show that mtTFA proteins are highly expressed in cancer and drug-resistant cells compared to normal cells, and the mtTFA expression is upregulated by signals of oxidative and DNA damage stress in cancer cells. [review]

  4. TFAM overexpression suppressed mitoROS and their upregulation in rat cardiomyocytes.

  5. TFAM dimerization enhances mitochondrial DNA compaction by promoting looping of the DNA.

  6. The combination of strong mtTFA expression and a high survivin (show BIRC5 Antibodies) index may predict a poor prognosis in patients with pancreatic ductal adenocarcinoma

  7. expression of PGC1alpha and TFAM varies between ovarian carcinoma subtypes; clear-cell carcinoma consists of undetectability of PGC1alpha/TFAM, and low ERalpha (show ESR1 Antibodies)/Ki-67 (show MKI67 Antibodies). high-grade serous carcinomas had a converse state of PGC1alpha/TFAM, ERalpha (show ESR1 Antibodies) positivity and high Ki-67 (show MKI67 Antibodies) index

  8. Methylation of TFAM promoters changed 2 days after gastric bypass.

  9. These data disclose a novel mechanism by which ERK1/2 (show MAPK1/3 Antibodies) regulates mitochondrial function through direct phosphorylation of TFAM.

  10. Data suggest that miitochondrial transcription factor A (show GTF3A Antibodies) (mtTFA) may be a novel target for the treatment of pancreatic ductal adenocarcinoma (PDAC).

Pig (Porcine) Transcription Factor A, Mitochondrial (TFAM) interaction partners

  1. TFAM may exert a critical role in porcine gametogenesis and preimplantation embryo development.

Cow (Bovine) Transcription Factor A, Mitochondrial (TFAM) interaction partners

  1. Our results suggest that TFAM plays an important role in lipid metabolism and may be a strong candidate gene for obesity in mammals.

  2. de novo mtTFA expression associated with mitochondrial biogenesis activation & high levels of nuclear respiratory factor-1 (show NRF1 Antibodies) mRNA from oocyte stage onwards argue for essential function of these factors during the first steps of bovine embryogenesis.

Mouse (Murine) Transcription Factor A, Mitochondrial (TFAM) interaction partners

  1. TFAM binds to RNA-containing 4-way junctions but does not bind appreciably to RNA hairpins, internal loops, or linear RNA:DNA hybrids.

  2. Data show that mitochondrial transcription factor A (TFAM) packages single mitochondrial DNA (mtDNA) molecules.

  3. There was upregulation of mtDNA and TFAM in 6-wk diabetic mice, suggesting that TFAM activation could be a therapeutic strategy to treat peripheral neuropathy.

  4. This study demonistrated that Tfam gene inactive patkinsin disease cause dopamine loss and circadian rhythm disorder.

  5. Mitochondrial transcription factor A, an endogenous danger signal, promotes TNFalpha (show TNF Antibodies) release via RAGE (show AGER Antibodies)- and TLR9 (show TLR9 Antibodies)-responsive plasmacytoid dendritic cells.

  6. overexpression of TFAM can restore mitochondrial function to normal levels in NYGGF4 (show PID1 Antibodies)-overexpressing adipocytes

  7. Acute exercise induces tumour suppressor protein p53 (show TP53 Antibodies) translocation to the mitochondria and promotes a p53 (show TP53 Antibodies)-Tfam-mitochondrial DNA complex in skeletal muscle.

  8. Data indicate that TFAM-deficient keratinocytes failed to generate mitochondria-derived reactive oxygen species, and prevented the transmission of Notch (show NOTCH1 Antibodies) and beta-catenin (show CTNNB1 Antibodies) signals for epidermal differentiation and hair follicle development.

  9. The reduction of mitochondrial transcription factor A (TFAM) in adipose tissue increases mitochondria oxidation capacity due to complex I deficiency and greater uncoupling.

  10. Data suggest that microRNA 494 regulates mitochondrial biogenesis by down-regulating mtTFA (mitochondrial transcription factor A) and Foxj3 (forkhead box J3 protein) during myocyte differentiation and skeletal muscle adaptation to physical exercise.

TFAM Antigen Profile

Protein Summary

This gene encodes a key mitochondrial transcription factor containing two high mobility group motifs. The encoded protein also functions in mitochondrial DNA replication and repair. Sequence polymorphisms in this gene are associated with Alzheimer's and Parkinson's diseases. There are pseudogenes for this gene on chromosomes 6, 7, and 11. Alternative splicing results in multiple transcript variants.

Gene names and symbols associated with TFAM

  • transcription factor A, mitochondrial (TFAM) antibody
  • transcription factor A, mitochondrial (tfam) antibody
  • transcription factor A, mitochondrial (Tfam) antibody
  • AI661103 antibody
  • Hmgts antibody
  • MGC153358 antibody
  • MTTF1 antibody
  • Mttfa antibody
  • mttfa-A antibody
  • TCF6 antibody
  • TCF6L1 antibody
  • TCF6L2 antibody
  • TCF6L3 antibody
  • tsHMG antibody
  • xl-mtTFA antibody
  • zgc:153358 antibody

Protein level used designations for TFAM

transcription factor A, mitochondrial , HMG box mitochondrial transcription factor , mitochondrial transcription factor 1 , mitochondrial transcription factor A , transcription factor 6 , transcription factor 6-like 1 , transcription factor 6-like 2 (mitochondrial transcription factor) , transcription factor 6-like 3 , mtTFA , transcription factor 6-like 2 , TS-HMG , testis-specific HMG-box protein m-tsHMG , testis-specific high mobility group protein

GENE ID SPECIES
373888 Gallus gallus
394385 Xenopus laevis
571106 Danio rerio
7019 Homo sapiens
488989 Canis lupus familiaris
397279 Sus scrofa
510059 Bos taurus
21780 Mus musculus
83474 Rattus norvegicus
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