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TFAM encodes a key mitochondrial transcription factor containing two high mobility group motifs. Additionally we are shipping TFAM Proteins (12) and TFAM Kits (7) and many more products for this protein.
Showing 10 out of 139 products:
Cow (Bovine) Polyclonal TFAM Primary Antibody for WB - ABIN2777277
Shi, Burkart, Nicoloro, Czech, Straubhaar, Corvera: Paradoxical effect of mitochondrial respiratory chain impairment on insulin signaling and glucose transport in adipose cells. in The Journal of biological chemistry 2008
Show all 7 references for ABIN2777277
Human Polyclonal TFAM Primary Antibody for EIA, FACS - ABIN955168
Corneveaux, Myers, Allen, Pruzin, Ramirez, Engel, Nalls, Chen, Lee, Chewning, Villa, Meechoovet, Gerber, Frost, Benson, OReilly, Chibnik, Shulman, Singleton, Craig, Van Keuren-Jensen, Dunckley, Bennett, De Jager, Heward, Hardy, Reiman, Huentelman: Association of CR1, CLU and PICALM with Alzheimer's disease in a cohort of clinically characterized and neuropathologically verified individuals. in Human molecular genetics 2010
Show all 2 references for ABIN955168
Human Polyclonal TFAM Primary Antibody for IF, IHC - ABIN1533816
Parisi, Clayton: Similarity of human mitochondrial transcription factor 1 to high mobility group proteins. in Science (New York, N.Y.) 1991
Rat (Rattus) Polyclonal TFAM Primary Antibody for WB - ABIN411602
Arduini, Serviddio, Escobar, Tormos, Bellanti, Viña, Monsalve, Sastre: Mitochondrial biogenesis fails in secondary biliary cirrhosis in rats leading to mitochondrial DNA depletion and deletions. in American journal of physiology. Gastrointestinal and liver physiology 2011
Human Polyclonal TFAM Primary Antibody for FACS, IF - ABIN654229
Shulman, Chibnik, Aubin, Schneider, Bennett, De Jager: Intermediate phenotypes identify divergent pathways to Alzheimer's disease. in PLoS ONE 2010
Mouse (Murine) Polyclonal TFAM Primary Antibody for WB - ABIN2779902
Noack, Bednarek, Heidler, Ladig, Holtz, Szibor: TFAM-dependent and independent dynamics of mtDNA levels in C2C12 myoblasts caused by redox stress. in Biochimica et biophysica acta 2006
Results showed that TFAM formed oligomers in mitochondria by in situ chemical cross-linking and suggested the importance of the dimerization of TFAM molecules in the distribution of mtDNA in cells.
Report failed upregulation of TFAM protein and mitochondrial DNA in oxidatively deficient fibers in skeletal muscle of chronic obstructive pulmonary disease patients.
Data show that mtTFA proteins are highly expressed in cancer and drug-resistant cells compared to normal cells, and the mtTFA expression is upregulated by signals of oxidative and DNA damage stress in cancer cells. [review]
TFAM overexpression suppressed mitoROS and their upregulation in rat cardiomyocytes.
TFAM dimerization enhances mitochondrial DNA compaction by promoting looping of the DNA.
The combination of strong mtTFA expression and a high survivin (show BIRC5 Antibodies) index may predict a poor prognosis in patients with pancreatic ductal adenocarcinoma
expression of PGC1alpha and TFAM varies between ovarian carcinoma subtypes; clear-cell carcinoma consists of undetectability of PGC1alpha/TFAM, and low ERalpha (show ESR1 Antibodies)/Ki-67 (show MKI67 Antibodies). high-grade serous carcinomas had a converse state of PGC1alpha/TFAM, ERalpha (show ESR1 Antibodies) positivity and high Ki-67 (show MKI67 Antibodies) index
Methylation of TFAM promoters changed 2 days after gastric bypass.
These data disclose a novel mechanism by which ERK1/2 (show MAPK1/3 Antibodies) regulates mitochondrial function through direct phosphorylation of TFAM.
Data suggest that miitochondrial transcription factor A (show GTF3A Antibodies) (mtTFA) may be a novel target for the treatment of pancreatic ductal adenocarcinoma (PDAC).
TFAM may exert a critical role in porcine gametogenesis and preimplantation embryo development.
Our results suggest that TFAM plays an important role in lipid metabolism and may be a strong candidate gene for obesity in mammals.
de novo mtTFA expression associated with mitochondrial biogenesis activation & high levels of nuclear respiratory factor-1 (show NRF1 Antibodies) mRNA from oocyte stage onwards argue for essential function of these factors during the first steps of bovine embryogenesis.
During muscle differentiation, Tfam protein levels are regulated by the availability of Tfam mRNA, which is controlled by both transcription and mRNA stability.
TFAM binds to RNA-containing 4-way junctions but does not bind appreciably to RNA hairpins, internal loops, or linear RNA:DNA hybrids.
Data show that mitochondrial transcription factor A (TFAM) packages single mitochondrial DNA (mtDNA) molecules.
There was upregulation of mtDNA and TFAM in 6-wk diabetic mice, suggesting that TFAM activation could be a therapeutic strategy to treat peripheral neuropathy.
This study demonistrated that Tfam gene inactive patkinsin disease cause dopamine loss and circadian rhythm disorder.
Mitochondrial transcription factor A, an endogenous danger signal, promotes TNFalpha (show TNF Antibodies) release via RAGE (show AGER Antibodies)- and TLR9 (show TLR9 Antibodies)-responsive plasmacytoid dendritic cells.
overexpression of TFAM can restore mitochondrial function to normal levels in NYGGF4 (show PID1 Antibodies)-overexpressing adipocytes
Acute exercise induces tumour suppressor protein p53 (show TP53 Antibodies) translocation to the mitochondria and promotes a p53 (show TP53 Antibodies)-Tfam-mitochondrial DNA complex in skeletal muscle.
Data indicate that TFAM-deficient keratinocytes failed to generate mitochondria-derived reactive oxygen species, and prevented the transmission of Notch (show NOTCH1 Antibodies) and beta-catenin (show CTNNB1 Antibodies) signals for epidermal differentiation and hair follicle development.
The reduction of mitochondrial transcription factor A (TFAM) in adipose tissue increases mitochondria oxidation capacity due to complex I deficiency and greater uncoupling.
This gene encodes a key mitochondrial transcription factor containing two high mobility group motifs. The encoded protein also functions in mitochondrial DNA replication and repair. Sequence polymorphisms in this gene are associated with Alzheimer's and Parkinson's diseases. There are pseudogenes for this gene on chromosomes 6, 7, and 11. Alternative splicing results in multiple transcript variants.
transcription factor A, mitochondrial
, HMG box mitochondrial transcription factor
, mitochondrial transcription factor 1
, mitochondrial transcription factor A
, transcription factor 6
, transcription factor 6-like 1
, transcription factor 6-like 2 (mitochondrial transcription factor)
, transcription factor 6-like 3
, transcription factor 6-like 2
, testis-specific HMG-box protein m-tsHMG
, testis-specific high mobility group protein