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TRPC4 encodes a member of the canonical subfamily of transient receptor potential cation channels. Additionally we are shipping TRPC4 Antibodies (127) and many more products for this protein.
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STIM1L (show STIM1 Proteins) and TRPC1 (show TRPC1 Proteins)/4 are working together in myotubes to ensure efficient store refilling and a proper differentiation program.
These findings suggest identification of an important experimental tool compound, which has much higher potency for inhibiting TRPC1 (show TRPC1 Proteins)/4/5 channels than previously reported agents, impressive specificity, and graded subtype selectivity within the TRPC1 (show TRPC1 Proteins)/4/5 channel family.
silencing of TRPC4 alleviates angiogenesis induced by oxidized low-density lipoprotein in human coronary artery endothelial cells through inactivation of VEGF (show VEGFA Proteins) and NF-kappaB (show NFKB1 Proteins).
slow phase of Gi/o-mediated TRPC4 activation was diminished by inhibiting RhoA (show RHOA Proteins) or enhancing PLCdelta function
Studies indicate potential roles for Rasd1 (show RASD1 Proteins) small G protein (show RAC2 Proteins) and leptin (show LEP Proteins) in TRPC4 cation channel (show TRPV1 Proteins) activation.
Galpha (show SUCLG1 Proteins)(i2) activates the TRPC4 channel by direct binding.
This study identifies a novel role for TRPC4 in the regulation of autophagy in vascular endothelial cells.
The higher amplitude of store-operated Ca2 (show CA2 Proteins)+ entry was associated to the over-expression for Stim2 (show Stim2 Proteins), Orai2 (show ORAI2 Proteins)-3, and TRPC1 (show TRPC1 Proteins) while Stim2 (show Stim2 Proteins) levels remained constant and Stim1 (show STIM1 Proteins), Orai1, Orai3, TRPC1 (show TRPC1 Proteins) and TRPC4 proteins were over-expressed in primary myelofibrosis.
a membrane-targeting domain of the transient receptor potential canonical (TRPC)4 channel unrelated to its formation of a tetrameric structure
Tarbp2 (show TARBP2 Proteins) binding to TRPC4 promotes changes of cytosolic Ca(2 (show CA2 Proteins)+) and, thereby, leads to a dynamic regulation of Dicer (show DICER1 Proteins) activity, essentially at low endogenous Dicer (show DICER1 Proteins) concentrations.
These results indicate the contribution of heteromultimeric channels from TRPC1 (show TRPC1 Proteins), TRPC4, and TRPC5 (show TRPC5 Proteins) subunits to the regulation of mechanisms underlying spatial working memory and flexible relearning by facilitating proper synaptic transmission in hippocampal neurons.
the antidepressant and anxiolytic-like effects of a newly identified TRPC4/C5 inhibitor, M084.
TRPC4 knockdownsuppressed the activation of ERK (show EPHB2 Proteins), p38 MAPK (show MAPK14 Proteins) and AKT (show AKT1 Proteins) signalingpathway.
Changes in ion selectivity and pore dilation of the TRPC4 channel elicited by the Galphai2 (show GNAI2 Proteins) subunit, were studied.
Constitutive ablation of TRPC4 in the amygdala is associated with diminished anxiety levels.
Data suggest that TRPC1 (show TRPC1 Proteins) and TRPC4 are involved in the sprouting of sensory neurons following bladder cystitis, which leads to overactive bladder disease.
Data indicate that kisspeptin activates TRPC4 channels through PIP(2) depletion and cSrc tyrosine kinase activation in GnRH neurons.
the S4-S5 linker is a critical constituent of TRPC4/C5 channel gating and that disturbance of its sequence allows channel opening independent of any sensor domain.
The results of this study suggested that TRPC4, TRPM4 (show TRPM4 Proteins), TRPM8 (show TRPM8 Proteins) and TRPV1 (show TRPV1 Proteins), showed statistically significant variation in mRNA levels between DRGs from different segments, suggesting ganglion-specific regulation of TRP (show TYRP1 Proteins) channel gene expression.
This gene encodes a member of the canonical subfamily of transient receptor potential cation channels. The encoded protein forms a non-selective calcium-permeable cation channel that is activated by Gq-coupled receptors and tyrosine kinases, and plays a role in multiple processes including endothelial permeability, vasodilation, neurotransmitter release and cell proliferation. Single nucleotide polymorphisms in this gene may be associated with generalized epilepsy with photosensitivity. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene.
transient receptor potential 4
, transient receptor potential cation channel, subfamily C, member 5
, transient receptor potential cation channel, subfamily C, member 4
, short transient receptor potential channel 4-like
, short transient receptor potential channel 4
, trp-related protein 4
, capacitative calcium entry channel Trp4
, putative capacitative calcium entry channel
, receptor-activated cation channel TRP4
, transient receptor protein 4
, capacitative calcium entry channel 1
, transient receptor potential channel 4
, transient receptor potential protein 4
, transient receptor potential cation channel TRPC4 middle region 2