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TRPC5 belongs to the transient receptor family. Additionally we are shipping Transient Receptor Potential Cation Channel, Subfamily C, Member 5 Proteins (7) and many more products for this protein.
Showing 10 out of 85 products:
Human Monoclonal TRPC5 Primary Antibody for IP, IHC - ABIN863137
Bahnasi, Wright, Milligan, Dedman, Zeng, Hopkins, Bateson, Beech: Modulation of TRPC5 cation channels by halothane, chloroform and propofol. in British journal of pharmacology 2008
findings reveal a novel signalling pathway involved in development of the semicircular canal system, and suggest a previously unrecognized role for NCS-1 (show NCS1 Antibodies) in mitochondrial function via its association with several mitochondrial proteins.
Data found that the pig adrenal medulla expressed predominantly TRPC1 (show TRPC1 Antibodies), TRPC5, and TRPC6 (show TRPC6 Antibodies) transcripts. The expression level of these TRPCs was significantly elevated in the adrenal medulla from pigs with metabolic syndrome.
TrpC5 plays an important role in VEGF-mediated tumor angiogenesis, suggesting its potential clinical value for anti-angiogenesis therapy
TRPC5 mRNA and protein levels were up-regulated in focal cortical dysplasia cortical lesions.
Suppressing TrpC5 expression decreased nuclear beta-catenin (show CTNNB1 Antibodies) accumulation, reduced the induction of ABCB1 (show ABCB1 Antibodies), and reversed 5-fluorouracil neoplastic resistance.
these results suggest that hypoosmotic cell-swelling activates Gq-coupled receptors, which in turn enhance the activation of TRPC5 by regulating this channel membrane trafficking
Clemizole exhibits a sixfold selectivity for TRPC5.
Riluzole can activate TRPC5 heterologously expressed in HEK293 cells as well as those endogenously expressed in the U-87 glioblastoma cell line.
TrpC5-containing circulating extracellular vesicles may transfer chemoresistance.
Microvesicles from tumor cells transferred TrpC5 to endothelial cells, inducing the expression of P-glycoprotein by activation of the transcription factor NFATc3 (show NFATC3 Antibodies) (nuclear factor of activated T cells isoform c3).
the S4-S5 linker is a critical constituent of TRPC4 (show TRPC4 Antibodies)/C5 channel gating and that disturbance of its sequence allows channel opening independent of any sensor domain.
Data using recombinant proteins expressed in vascular endothelial cells suggest that SigmaR1 (sigma 1-type opioid receptor (show SIGMAR1 Antibodies)) is not involved in regulation of calcium signaling via TRPC5/TRPM3 (show TRPM3 Antibodies) (transient receptor potential cation channels C5/M3).
the antidepressant and anxiolytic-like effects of a newly identified TRPC4 (show TRPC4 Antibodies)/C5 inhibitor, M084.
Loss or inhibition of TRPC5 abrogates podocyte cytoskeletal remodeling, prevents Rac1 activation, & stabilizes synaptopodin (show SYNPO Antibodies). Genetic deletion or pharmacologic inhibition of TRPC5 protected mice from albuminuria.
Is unaltered in TRPC5 KO mice, but is abolished in TRPC1 (show TRPC1 Antibodies) KO and TRPC1 (show TRPC1 Antibodies)/4 DKO mice.
NEB (show NEB Antibodies) cells selectively expressed the Ca(2 (show CA2 Antibodies)+)-permeable osmo- and mechanosensitive TRPC5 in their apical membranes, whereas immunoreactivity for TRP (show TYRP1 Antibodies) vanilloid-4 and TRP (show TYRP1 Antibodies) melastatin (show TRPM1 Antibodies)-3 was abundant in virtually all other airway epithelial cells
TRPC5 acts downstream of semaphorin signaling to cause changes in neuronal growth cone morphology and nervous system development.
Agents that deplete intracellular Ca(2 (show CA2 Antibodies)+) stores activate native heteromeric TRPC1 (show TRPC1 Antibodies)/C5 channels in vascular smooth muscle cells.
a novel function for TRPC5 that couples calcium signaling to a ubiquitin ligase pathway at the centrosome and thereby orchestrates dendrite patterning and connectivity in the brain
findings demonstrate that highly cold-sensitive TRPC5 channels are a molecular component for detection and regional adaptation to cold temperatures in the peripheral nervous system that is distinct from noxious cold sensing
Nitrix oxide can negatively modulate endogenous TRPC5-containing channels through an indirect mechanism.
analysis of a TRPC6 (show TRPC6 Antibodies)-TRPC5 channel cascade that restricts endothelial cell movement
This gene belongs to the transient receptor family. It encodes one of the seven mammalian TRPC (transient receptor potential channel) proteins. The encoded protein is a multi-pass membrane protein and is thought to form a receptor-activated non-selective calcium permeant cation channel. The protein is active alone or as a heteromultimeric assembly with TRPC1, TRPC3, and TRPC4. It also interacts with multiple proteins including calmodulin, CABP1, enkurin, Na(+)-H+ exchange regulatory factor (NHERF ), interferon-induced GTP-binding protein (MX1), ring finger protein 24 (RNF24), and SEC14 domain and spectrin repeat-containing protein 1 (SESTD1).
transient receptor potential cation channel, subfamily C, member 5
, transient receptor potential channel subfamily C member 5
, short transient receptor potential channel 5
, transient receptor potential channel 5
, transient receptor protein 5
, capacitative calcium entry channel 2
, trp-related protein 5
, vtransient receptor potential cation channel, subfamily C, member 5