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Capsaicin, the main pungent ingredient in hot chili peppers, elicits a sensation of burning pain by selectively activating sensory neurons that convey information about noxious stimuli to the central nervous system. Additionally we are shipping TRPV1 Kits (24) and TRPV1 Proteins (7) and many more products for this protein.
Showing 10 out of 148 products:
Human Polyclonal TRPV1 Primary Antibody for IHC (p), WB - ABIN967211
Caterina, Schumacher, Tominaga, Rosen, Levine, Julius: The capsaicin receptor: a heat-activated ion channel in the pain pathway. in Nature 1997
Show all 5 references for ABIN967211
Human Monoclonal TRPV1 Primary Antibody for ELISA, WB - ABIN563377
Choi, Park, Jo, Kang, Park, Kim, Hong, Kim, Lee, Yoon: Endogenous expression of TRPV1 channel in cultured human melanocytes. in Journal of dermatological science 2009
Show all 2 references for ABIN563377
Human Polyclonal TRPV1 Primary Antibody for IF (p), IHC (p) - ABIN675503
Assas, Wakid, Zakai, Miyan, Pennock: Transient receptor potential vanilloid 1 expression and function in splenic dendritic cells: a potential role in immune homeostasis. in Immunology 2016
Results demonstrate that cell motility and Ca(2 (show CA2 Antibodies)+)i activity are affected by pharmacological agents that target TRPV1, indicating a novel role for this channel during cell migration.
Using knock-down studies, we also show that TRPV1 is required for normal heat-induced locomotion.
Our results indicate that TRPV1 channel inhibitors show radiosensitizing action in cancer cells through inhibition of early DNA damage response
Temperature sensors in TRPV1 activate in two steps to favor opening, and that the binding of sodium to an extracellular site exerts allosteric control over temperature-sensor activation and opening of the pore.
The impaired Ca2 (show CA2 Antibodies)+ homeostasis found in preeclampsia may correlate with the reduced TRPV-1 expression in preeclamptic placentas.
a high concentration of calcium in seawater exacerbated lung injury, and TRPV1 channels were notable mediators of the calcium increase initiated by the seawater challenge.
TRPV1 channel modulation by hyaluronan reduces pain.
Results suggest that non-neuronal TRPV1 may contribute to acute pain in herpes zoster.
Cellular physiology and molecular biology methods show that the TRPV1 pain receptor is another pharmacologic target of aspirin.
The effects of specific agents on TRPV1 and TRPM8 (show TRPM8 Antibodies) channels are intricately interrelated.
Data show that the number of transient receptor potential vanilloid 1 (TRPV1)+/CD4+ inflammatory cells increased in the nasal mucosa of patients with allergic rhinitis (AR), compared with that of control subjects.
No change in tmFRET was observed with the TRPV1 agonist capsaicin.
TRPV1 play a role in airway inflammation in asthmatic mice.
Electroacupuncture at ST25 was found to inhibit jejunal motility in an intensity-dependent manner, via a mechanism in which sympathetic nerves and TRPV1 receptors play an important role.
These findings indicate that tongue heat sensitivity and hypersensitivity are dependent on the expression of transient receptor potential vanilloid 1 which is regulated via MeCP2 (show MECP2 Antibodies) signaling in trigeminal ganglion neurons innervating the tongue.
The behavioral and molecular data indicated that TRPV1 is strongly modulated by Cdk5 (show CDK5 Antibodies)-mediated phosphorylation at position threonine-407(mouse)/threonine406(rat).
Data show that in transient receptor potential vanilloid 1 (TRPV1) knockout allergic rhinitis (AR) mice, eosinophil infiltration, Th2/Th17 cytokines in the nasal mucosa, and IgE levels in serum decreased, compared with wild-type AR mice.
This study suggests that targeting TRPV1 is beneficial in controlling body weight and TRPV1-associated mechanisms in mice.
The TRPV1-mediated amendment of mitochondrial dysfunction may represent a novel target for management of early cardiac dysfunction.
Trpv1 is involved in the ocular itch response in allergic conjunctivitis.
TRPV4 (show TRPV4 Antibodies)-mediated nociceptive information from the peripheral tissue excluding the spinal pathway might be involved the formalin behavioral response during phase I. Only TRPV1 might regulate the formalin behavioral response in peripheral neuron.
This study is the first to shed light on the structural determinants required for the interaction between TRPV1 and evodiamine, and gives new suggestions for the rational design of novel TRPV1 ligands.
TRPV1 is expressed in cells that are particularly active in Ca(2 (show CA2 Antibodies)) exchange as well as in cells with significant water transport activity in eyes of New Zealand White rabbits and humans
There is no correlation of expression of thromboxane A2 receptor (show TBXA2R Antibodies) with TRPV1 in dorsal root ganglia and nodose ganglia.
HCl-induced activation of TRPV1 causes ATP release from esophageal epithelial cells that causes release of CGRP (show CALCA Antibodies) and SP from esophageal submucosal neurons.
Capsaicin increased secretion and upregulated the expression of TRPV1 and AQP5 (show AQP5 Antibodies) in transplanted submandibular glands.
The contractile effect of anandamide in the guinea-pig small intestine is mediated by prostanoids but not TRPV1 receptors or capsaicin-sensitive nerves.
Allergic airway inflammation can induce the expression of TRPV1 in tracheal A-fiber neurons.
Capsaicin, the main pungent ingredient in hot chili peppers, elicits a sensation of burning pain by selectively activating sensory neurons that convey information about noxious stimuli to the central nervous system. The protein encoded by this gene is a receptor for capsaicin and is a non-selective cation channel that is structurally related to members of the TRP family of ion channels. This receptor is also activated by increases in temperature in the noxious range, suggesting that it functions as a transducer of painful thermal stimuli in vivo. Four transcript variants encoding the same protein, but with different 5' UTR sequence, have been described for this gene.
, capsaicin receptor
, osm-9-like TRP channel 1
, transient receptor potential cation channel subfamily V member 1
, vanilloid receptor 1
, vanilloid receptor subtype 1
, vanilloid receptor type 1 like protein 1
, vanilloid type 1 receptor
, transient receptor potential vanilloid 1a
, transient receptor potential vanilloid 1b
, cation channel
, transient receptor potential cation channel V1
, transient receptor potential vanilloid type 1
, transient receptor potential V1
, vanilloid receptor-like protein