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Capsaicin, the main pungent ingredient in hot chili peppers, elicits a sensation of burning pain by selectively activating sensory neurons that convey information about noxious stimuli to the central nervous system. Additionally we are shipping TRPV1 Kits (26) and TRPV1 Proteins (7) and many more products for this protein.
Showing 10 out of 153 products:
Human Polyclonal TRPV1 Primary Antibody for IHC (p), WB - ABIN967211
Caterina, Schumacher, Tominaga, Rosen, Levine, Julius: The capsaicin receptor: a heat-activated ion channel in the pain pathway. in Nature 1997
Show all 5 references for ABIN967211
Human Monoclonal TRPV1 Primary Antibody for ELISA, WB - ABIN521348
Zheng, Zhang, Han, Sun, Zhou, Zhao, Wang: Nerve growth factor rescues diabetic mice heart after ischemia/reperfusion injury via up-regulation of the TRPV1 receptor. in Journal of diabetes and its complications 2015
Show all 2 references for ABIN521348
Human Polyclonal TRPV1 Primary Antibody for IHC (p), WB - ABIN657909
Miyano, Minami, Yokoyama, Ohbuchi, Yamaguchi, Murakami, Shiraishi, Yamamoto, Matoba, Uezono: Tramadol and its metabolite m1 selectively suppress transient receptor potential ankyrin 1 activity, but not transient receptor potential vanilloid 1 activity. in Anesthesia and analgesia 2015
Results demonstrate that cell motility and Ca(2 (show CA2 Antibodies)+)i activity are affected by pharmacological agents that target TRPV1, indicating a novel role for this channel during cell migration.
Using knock-down studies, we also show that TRPV1 is required for normal heat-induced locomotion.
No change in tmFRET was observed with the TRPV1 agonist capsaicin.
These findings suggest that the TRPA1 (show TRPA1 Antibodies)-TRPV1 interaction may play an important role in regulating the function and excitability of pulmonary sensory neurons during airway inflammation
TRPV1 was expressed in tongue, epiglottis, and pharynx, with higher levels in CN V region (tongue) than in CN X region (epiglottis), and was localized at epithelial cells and nociceptive fibers in all studied regions.
the major objective of this review is to highlight the fact that TRPV1 channel can be treated as an effective therapeutic target for treating several pain- and nonpain-related physiological and pathological states.
HRH1 (show DHX8 Antibodies)-mediated sensitization of TRPV1 is involved in IBS. Ebastine, an antagonist of HRH1 (show DHX8 Antibodies), reduced visceral hypersensitivity, symptoms, and abdominal pain in patients with IBS.
This study suggests that the circadian rhythm in the esophagus may be important for the mediation of and/or the response to erosive damage in GERD patients.
TRPV1 is a molecular co-detector of body temperature and osmotic stress.
RhTx binding to the outer pore can induce TRPV1 heat activation.
Studies indicate that crosstalk between cannabinoid receptor type 1 (CB1 (show CNR1 Antibodies)) and transient receptor potential vanilloid 1 (TRPV1) modulates pain and inflammation in arthritis.
Interaction between the linker, pre-S1, and TRP (show TBPL1 Antibodies) domains determines folding, assembly, and trafficking of TRPV1 and TRPV4 (show TRPV4 Antibodies) channels.
This study suggests that targeting TRPV1 is beneficial in controlling body weight and TRPV1-associated mechanisms in mice.
The TRPV1-mediated amendment of mitochondrial dysfunction may represent a novel target for management of early cardiac dysfunction.
Trpv1 is involved in the ocular itch response in allergic conjunctivitis.
TRPV4 (show TRPV4 Antibodies)-mediated nociceptive information from the peripheral tissue excluding the spinal pathway might be involved the formalin behavioral response during phase I. Only TRPV1 might regulate the formalin behavioral response in peripheral neuron.
CPEB3 (show CPEB3 Antibodies)-regulated translation of TRPV1 RNA may play a role in fine-tuning thermal sensitivity of nociceptors.
The TRPV1 channel in rodents is a major target for antinociceptive effect of the probiotic Lactobacillus reuteri DSM 17938
Results revealed an important role of TRPV1 channels within the dorsal periaqueductal gray in the modulation of pain and in the phenomenon known as fear-induced antinociception in mice.
TRPV1 channels selectively modulate gastric vagal afferent tension receptor mechanosensitivity and may mediate the reduction in gastric vagal afferent mechanosensitivity in high fat diet-induced obesity
This study is the first to shed light on the structural determinants required for the interaction between TRPV1 and evodiamine, and gives new suggestions for the rational design of novel TRPV1 ligands.
TRPV1 is expressed in cells that are particularly active in Ca(2 (show CA2 Antibodies)) exchange as well as in cells with significant water transport activity in eyes of New Zealand White rabbits and humans
There is no correlation of expression of thromboxane A2 receptor (show TBXA2R Antibodies) with TRPV1 in dorsal root ganglia and nodose ganglia.
HCl-induced activation of TRPV1 causes ATP release from esophageal epithelial cells that causes release of CGRP (show CALCA Antibodies) and SP from esophageal submucosal neurons.
Capsaicin increased secretion and upregulated the expression of TRPV1 and AQP5 (show AQP5 Antibodies) in transplanted submandibular glands.
The contractile effect of anandamide in the guinea-pig small intestine is mediated by prostanoids but not TRPV1 receptors or capsaicin-sensitive nerves.
Allergic airway inflammation can induce the expression of TRPV1 in tracheal A-fiber neurons.
conclude that TRPV1 receptors in the nucleus of the solitary tract mediate thermal prolongation of the laryngeal chemoreflex
Results suggest that TRPV1 channels modulate the major pathways involved in sperm capacitation.
TRPV1 receptors are initially located in the post acrosomal area;after capacitation they relocalize to the anterior region of the sperm head
TRPV1 activation in endothelial cells may elicit a Ca(2 (show CA2 Antibodies)+) -dependent effect on PP2B-PKC (show PKC Antibodies) signalling, which leads to dephosphorylation of eNOS (show NOS3 Antibodies)
TRPV1 activation in endothelial cells may trigger Ca(2 (show CA2 Antibodies)+)-dependent PI3K/Akt (show AKT1 Antibodies)/CaMKII (show CAMK2G Antibodies) signalling, which leads to enhanced phosphorylation of TRPV1, increased TRPV1-eNOS (show NOS3 Antibodies) complex formation, eNOS (show NOS3 Antibodies) activation and, ultimately, NO production.
Capsaicin, the main pungent ingredient in hot chili peppers, elicits a sensation of burning pain by selectively activating sensory neurons that convey information about noxious stimuli to the central nervous system. The protein encoded by this gene is a receptor for capsaicin and is a non-selective cation channel that is structurally related to members of the TRP family of ion channels. This receptor is also activated by increases in temperature in the noxious range, suggesting that it functions as a transducer of painful thermal stimuli in vivo. Four transcript variants encoding the same protein, but with different 5' UTR sequence, have been described for this gene.
, capsaicin receptor
, osm-9-like TRP channel 1
, transient receptor potential cation channel subfamily V member 1
, vanilloid receptor 1
, vanilloid receptor subtype 1
, vanilloid receptor type 1 like protein 1
, vanilloid type 1 receptor
, transient receptor potential vanilloid 1a
, transient receptor potential vanilloid 1b
, cation channel
, transient receptor potential cation channel V1
, transient receptor potential vanilloid type 1
, transient receptor potential V1
, vanilloid receptor-like protein