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TRPV4 encodes a member of the OSM9-like transient receptor potential channel (OTRPC) subfamily in the transient receptor potential (TRP) superfamily of ion channels. Additionally we are shipping TRPV4 Proteins (6) and TRPV4 Kits (2) and many more products for this protein.
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Mouse (Murine) Polyclonal TRPV4 Primary Antibody for IHC, WB - ABIN351282
Arniges, Fernuandez-Fernuandez, Albrecht, Schaefer, Valverde: Human TRPV4 channel splice variants revealed a key role of ankyrin domains in multimerization and trafficking. in The Journal of biological chemistry 2006
Show all 6 references for ABIN351282
Human Polyclonal TRPV4 Primary Antibody for ICC, IF - ABIN259364
Butenko, Dzamba, Benesova, Honsa, Benfenati, Rusnakova, Ferroni, Anderova: The increased activity of TRPV4 channel in the astrocytes of the adult rat hippocampus after cerebral hypoxia/ischemia. in PLoS ONE 2012
Show all 4 references for ABIN259364
Chicken Polyclonal TRPV4 Primary Antibody for IHC, WB - ABIN2776284
Sampat, Dermksian, Oungoulian, Winchester, Bulinski, Ateshian, Hung: Applied osmotic loading for promoting development of engineered cartilage. in Journal of biomechanics 2013
TRPP2 and TRPV4 are mechanosensitive channels in the endocardium.Oscillatory flow modulates mechanosensitive klf2a expression through trpv4 and trpp2 during heart valve development.
TRPP2 utilizes TRPV4 to form a mechano- and thermosensitive molecular sensor in the cilium.
Age-dependence of heat-activated seizure susceptibility mimicks the mRNA expression of TRPV4 and glutamate (show GRIN2A Antibodies) receptors.
TRPV4 present in all sensory organs of adult zebrafish.
Study reports cloning of a zebrafish trpv4 cDNA and assaying its expression during embryogenesis; trpv4 is expressed as maternal mRNA in 4-cell embryos and later zygotic expression is first observed in the forming notochord at the one somite stage.
OS-9 (show OS9 Antibodies) regulates the secretory transport of TRPV4 and appears to protect TRPV4 subunits from the precocious ubiquitination and ER-associated degradation.
TRPV4 rs6606743 SNP was found to significantly contribute to the development of osmotic airway hyperresponsiveness in response to the decrease in osmolarity under inspiration of distilled water aerosol was studies in 189 patients with uncontrolled bronchial asthma, prevalence of AG + GG genotype frequency in the group of patients with asthma with osmotic hyperresponsiveness
Report of an Italian family with scapuloperoneal spinal muscular atrophy harboring the heterozygous missense mutation c.806G>A in the TRPV4 gene (p. R269H) and a literature review about scapuloperoneal spinal muscular atrophy
TRPV4 channel activity modulates uterine contractility and might represent a therapeutic target to address preterm labor.
In addition to the clear role TRPV4 plays in the growth plate, and its dysfunction leads to short-limbed and then short-trunked dwarfism, TRPV4 gain-of-function also leads to a state of increased bone turnover and osteopenia leading to fracture
This study demonstrated that the overexpression and distribution patterns of TRPV4 may be linked with the intractable epilepsy caused by tuberous sclerosis complex.
Overexpression and altered cellular distribution of TRPV4 observed in focal cortical dysplasia suggest that TRPV4 may potentially contribute to the epileptogenesis of focal cortical dysplasia
Role of endothelial TRPV4 channels in vascular actions of the endocannabinoid, 2-arachidonoylglycerol
the activation of myenteric TRPV4 and the subsequent production of NO by these neurons have the potential to become an important target for the pharmacological treatment of GI disorders with predominant hypermotility symptoms.
these data strongly suggest endogenous TRPV4 channels as a mechanosensor, mediating cyclic stretch-induced realignment of hESC-CMs (show Cd2ap Antibodies).
Identify TRPV4 as novel regulator of neutrophil activation and suggest contributions of both parenchymal and neutrophilic TRPV4 in the pathophysiology of acute lung injury.
TRPV4-AQP4 (show AQP4 Antibodies) interactions 'turbocharge' astroglial sensitivity to small osmotic gradients
The results support a model whereby TRPV4 differentially regulates cell volume, lipid, and calcium signals in nonpigmented epithelial and pigment epithelial cell types and therefore represents a potential target for antiglaucoma medications.
TRPV4 functions as a pruriceptor-TRP (show TYRP1 Antibodies) in skin keratinocytes in histaminergic itch, a novel basic concept with translational-medical relevance
the activation of TRPV4 is upregulated and involved in neuronal injury during cerebral ischemia
Aquaporin-mediated fast swelling kinetics play a key role in cell volume regulation (together with TRPV4) and calcium signaling in astrocytes
In subcutaneous adipose tissue, a high fat diet elevated TRPV4, exercise, and exercise plus rutin completely reduced TRPV4 to normal level.
TRPV4 regulates neuronal excitability and social behavior through its activation at the physiological temperature in vivo.
TRPV4-mediated nociceptive information from the peripheral tissue excluding the spinal pathway might be involved the formalin behavioral response during phase I. Only TRPV1 (show TRPV1 Antibodies) might regulate the formalin behavioral response in peripheral neuron.
TRPV4 channels regulate tumor angiogenesis by selectively inhibiting tumor endothelial cell proliferation.
Data indicate a physiologic function of transient receptor potential vanilloid 4 (TRPV4) in the regulation of blood-cerebrospinal fluid barrier (BCSFB) permeability.
Hyposmotic shock-induced TRPV4 channel activation regulates hemichannel-mediated ATP release and Na-K-ATPase (show ATP1A1 Antibodies) activity in lens epithelium.
The large amounts of transported calcium and the short signaling ways suggest a potentially important role of TRPV4 in many physiological processes.
TRPV4 is present in articular chondrocytes in swine, and chondrocyte response to hypo-osmotic stress is mediated by this channel, which involves both an extracellular Ca(2 (show CA2 Antibodies)+) and intracellular Ca(2 (show CA2 Antibodies)+) release.
TRPV4 channels activity in bovine articular chondrocytes are regulated by obesity-associated mediators.
TRPV4 channels mediate cyclic strain-induced endothelial cell reorientation through integrin-to-integrin signaling.
This gene encodes a member of the OSM9-like transient receptor potential channel (OTRPC) subfamily in the transient receptor potential (TRP) superfamily of ion channels. The encoded protein is a Ca2+-permeable, nonselective cation channel that is thought to be involved in the regulation of systemic osmotic pressure. Mutations in this gene are the cause of spondylometaphyseal and metatropic dysplasia and hereditary motor and sensory neuropathy type IIC. Multiple transcript variants encoding different isoforms have been found for this gene.
transient receptor potential cation channel subfamily V member 4
, transient receptor potential cation channel, subfamily V, member 4
, transient receptor potential cation channel subfamily V member 4-like
, OSM9-like transient receptor potential channel 4
, osm-9-like TRP channel 4
, osmosensitive transient receptor potential channel 4
, transient receptor potential protein 12
, vanilloid receptor-like channel 2
, vanilloid receptor-related osmotically activated channel
, vanilloid receptor-like protein 2
, vanilloid receptor-related osmotically-activated channel
, transient receptor potential cation channel, subfamily 5, member 4
, vanilloid receptor-related osmotically activated channel (Vroac)
, vanilloid receptor-related osmotically activated channel protein