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anti-Transmembrane Channel-Like 8 (TMC8) Antibodies

Epidermodysplasia verruciformis (EV) is an autosomal recessive dermatosis characterized by abnormal susceptibility to human papillomaviruses (HPVs) and a high rate of progression to squamous cell carcinoma on sun-exposed skin. Additionally we are shipping TMC8 Proteins (7) and many more products for this protein.

list all antibodies Gene Name GeneID UniProt
TMC8 147138 Q8IU68
TMC8 688276  
TMC8 217356 Q7TN58
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Top anti-TMC8 Antibodies at antibodies-online.com

Showing 10 out of 67 products:

Catalog No. Reactivity Host Conjugate Application Images Quantity Supplier Delivery Price Details
Human Rabbit Un-conjugated IHC, ELISA Immunohistochemistry analysis of paraffin-embedded human tonsil, using TMC8 Antibody. The picture on the right is treated with the synthesized peptide. 100 μg Log in to see 2 to 3 Days
$302.50
Details
Human Rabbit Un-conjugated WB WB Suggested Anti-TMC8 Antibody Titration: 0.2-1 ug/mlELISA Titer: 1:62500Positive Control: 721_B cell lysate 100 μL Log in to see 2 to 3 Days
$289.00
Details
Human Rabbit Un-conjugated WB TMC8 Antibody (N-term) (ABIN658164) western blot analysis in NCI-H292 cell line lysates (35 µg/lane). This demonstrates the TMC8 antibody detected the TMC8 protein (arrow). 400 μL Log in to see 10 to 11 Days
$324.50
Details
Human Rabbit Un-conjugated WB 50 μg Log in to see 8 to 10 Days
$551.83
Details
Human Rabbit Un-conjugated EIA, IHC (p), WB Immunohistochemistry of EVER2 in human brain with EVER2 antibody at 5 μg/ml. Western blot analysis of EVER2 in Jurkat cell lysate with AP30323PU-N EVER2 antibody at (A) 1 and (B) 2 μg/ml. 0.1 mg Log in to see 6 to 8 Days
$401.50
Details
Human Rabbit Un-conjugated EIA, WB Western blot analysis of EVER2 in rat thymus tissue lysate with AP30324PU-N EVER2 antibody at (A) 1 and (B) 2 μg/ml. 0.1 mg Log in to see 6 to 8 Days
$401.50
Details
Human Rabbit Un-conjugated IHC (p), WB Human Testis: Formalin-Fixed, Paraffin-Embedded (FFPE) Human Placenta: Formalin-Fixed, Paraffin-Embedded (FFPE) 50 μg Log in to see 8 to 10 Days
$451.00
Details
Human Rabbit Un-conjugated ELISA, WB   100 μg Log in to see 15 to 19 Days
$455.07
Details
Human Rabbit Un-conjugated IHC, ELISA, WB   100 μg Log in to see 15 to 19 Days
$455.07
Details
Human Rabbit Un-conjugated IHC (p), WB Human Placenta: Formalin-Fixed, Paraffin-Embedded (FFPE) Human Testis: Formalin-Fixed, Paraffin-Embedded (FFPE) 50 μg Log in to see 6 to 8 Days
$500.50
Details

TMC8 Antibodies by Reactivity, Application, Clonality and Conjugate

Attributes Applications Host Clonality Conjugate
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Top referenced anti-TMC8 Antibodies

  1. Human Polyclonal TMC8 Primary Antibody for ELISA, WB - ABIN1002275 : Ramoz, Taïeb, Rueda, Montoya, Bouadjar, Favre, Orth: Evidence for a nonallelic heterogeneity of epidermodysplasia verruciformis with two susceptibility loci mapped to chromosome regions 2p21-p24 and 17q25. in The Journal of investigative dermatology 2000 (PubMed)
    Show all 3 references for ABIN1002275

  2. Human Polyclonal TMC8 Primary Antibody for IHC, ELISA - ABIN1002274 : Ramoz, Rueda, Bouadjar, Montoya, Orth, Favre: Mutations in two adjacent novel genes are associated with epidermodysplasia verruciformis. in Nature genetics 2002 (PubMed)
    Show all 3 references for ABIN1002274

  3. Human Polyclonal TMC8 Primary Antibody for IHC, ELISA - ABIN1535426 : Kurima, Yang, Sorber, Griffith: Characterization of the transmembrane channel-like (TMC) gene family: functional clues from hearing loss and epidermodysplasia verruciformis. in Genomics 2003 (PubMed)

More Antibodies against TMC8 Interaction Partners

Human Transmembrane Channel-Like 8 (TMC8) interaction partners

  1. Findings suggest that SNPs in EVER2 may be involved in the development of premalignant skin lesions that harbour beta-HPV, perhaps giving rise to SCC (show CYP11A1 Antibodies) tumours that have lost beta-HPV gene expression during progression.

  2. TMC6/EVER1 (show TMC6 Antibodies) and TMC8/EVER2 are known to be involved in the development of EV.

  3. A common genetic variation in TMC8 is associated with high-risk HPV infection and head and neck squamous cell carcinoma etiology.

  4. We found a possible correlation between the EVER2 TT genotype and the development of AK, suggesting a potential role of this polymorphism in the development of AK.

  5. EV is also a rare autosomal recessive genodermatosis involving susceptibility to human papillomavirus (HPV) infections and squamous cell carcinoma, caused in most cases by homozygous mutations in EVER1 (show TMC6 Antibodies) or EVER2.

  6. TMC8 was found to be localized in the endoplasmic reticulum (ER), where it inhibited receptor mediated Ca(2 (show CA2 Antibodies)+) release, activation of Ano1 (show ANO1 Antibodies) and volume regulated LRRC8 (show LRRC8A Antibodies)-related Cl(-) currents.

  7. Expression of both EVER1 (show TMC6 Antibodies) and EVER2 in B cells is activated immediately after Epstein-Barr virus (EBV) infection, whereas at later stages, it is strongly repressed by latent membrane protein 1-activated NF-kappaB (show NFKB1 Antibodies) signaling.

  8. Loss of the HPV-infection resistance EVER2 protein impairs NF-kappaB (show NFKB1 Antibodies) signaling pathways in keratinocytes.

  9. Ever2 interacts with the N-terminal domain of TRADD (show TRADD Antibodies), impairs the recruitment of TRAF2 (show TRAF2 Antibodies) and RIPK1 (show RIPK1 Antibodies) and promotes apoptosis.

  10. EVER2-deficient patients display mild T-cell abnormalities: a significant increase of memory CD4 (show CD4 Antibodies)+ and effector memory CD8 (show CD8A Antibodies)+ T cells, a bias of the T cell receptor Valphabeta and Vgammadelta repertoires and an increase of skin-homing CD4 (show CD4 Antibodies)+ T-cell subsets.

TMC8 Antigen Profile

Protein Summary

Epidermodysplasia verruciformis (EV) is an autosomal recessive dermatosis characterized by abnormal susceptibility to human papillomaviruses (HPVs) and a high rate of progression to squamous cell carcinoma on sun-exposed skin. EV is caused by mutations in either of two adjacent genes located on chromosome 17q25.3. Both of these genes encode integral membrane proteins that localize to the endoplasmic reticulum and are predicted to form transmembrane channels. This gene encodes a transmembrane channel-like protein with 8 predicted transmembrane domains and 3 leucine zipper motifs.

Gene names and symbols associated with TMC8

  • transmembrane channel-like 8 (TMC8) antibody
  • transmembrane channel-like 8 (Tmc8) antibody
  • transmembrane channel-like gene family 8 (Tmc8) antibody
  • EV2 antibody
  • Ever2 antibody
  • EVIN2 antibody
  • mFLJ00400 antibody

Protein level used designations for TMC8

transmembrane channel-like 8 , FLJ00400 protein-like , transmembrane channel-like protein 8-like , epidermodysplasia verruciformis 2 , epidermodysplasia verruciformis protein 2 , transmembrane channel-like protein 8 , uncharacterized protein LOC688276 , epidermodysplasia verruciformis protein 2 homolog

GENE ID SPECIES
483342 Canis lupus familiaris
513813 Bos taurus
100031099 Monodelphis domestica
100443950 Pongo abelii
100478575 Ailuropoda melanoleuca
100596943 Nomascus leucogenys
100615612 Pan troglodytes
147138 Homo sapiens
688276 Rattus norvegicus
217356 Mus musculus
Selected quality suppliers for anti-TMC8 (TMC8) Antibodies
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