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Epidermodysplasia verruciformis (EV) is an autosomal recessive dermatosis characterized by abnormal susceptibility to human papillomaviruses (HPVs) and a high rate of progression to squamous cell carcinoma on sun-exposed skin. Additionally we are shipping TMC8 Proteins (7) and many more products for this protein.
Showing 10 out of 62 products:
Human Polyclonal TMC8 Primary Antibody for ELISA, WB - ABIN1002275
Ramoz, Taïeb, Rueda, Montoya, Bouadjar, Favre, Orth: Evidence for a nonallelic heterogeneity of epidermodysplasia verruciformis with two susceptibility loci mapped to chromosome regions 2p21-p24 and 17q25. in The Journal of investigative dermatology 2000
Show all 3 references for ABIN1002275
Human Polyclonal TMC8 Primary Antibody for IHC, ELISA - ABIN1002274
Ramoz, Rueda, Bouadjar, Montoya, Orth, Favre: Mutations in two adjacent novel genes are associated with epidermodysplasia verruciformis. in Nature genetics 2002
Show all 3 references for ABIN1002274
Human Polyclonal TMC8 Primary Antibody for IHC, ELISA - ABIN1535426
Kurima, Yang, Sorber, Griffith: Characterization of the transmembrane channel-like (TMC) gene family: functional clues from hearing loss and epidermodysplasia verruciformis. in Genomics 2003
TMC6/EVER1 (show TMC6 Antibodies) and TMC8/EVER2 are known to be involved in the development of EV.
A common genetic variation in TMC8 is associated with high-risk HPV infection and head and neck squamous cell carcinoma etiology.
We found a possible correlation between the EVER2 TT genotype and the development of AK, suggesting a potential role of this polymorphism in the development of AK.
EV is also a rare autosomal recessive genodermatosis involving susceptibility to human papillomavirus (HPV) infections and squamous cell carcinoma, caused in most cases by homozygous mutations in EVER1 (show TMC6 Antibodies) or EVER2.
TMC8 was found to be localized in the endoplasmic reticulum (ER), where it inhibited receptor mediated Ca(2 (show CA2 Antibodies)+) release, activation of Ano1 (show ANO1 Antibodies) and volume regulated LRRC8 (show LRRC8A Antibodies)-related Cl(-) currents.
Expression of both EVER1 (show TMC6 Antibodies) and EVER2 in B cells is activated immediately after Epstein-Barr virus (EBV) infection, whereas at later stages, it is strongly repressed by latent membrane protein 1-activated NF-kappaB (show NFKB1 Antibodies) signaling.
Loss of the HPV-infection resistance EVER2 protein impairs NF-kappaB (show NFKB1 Antibodies) signaling pathways in keratinocytes.
Ever2 interacts with the N-terminal domain of TRADD (show TRADD Antibodies), impairs the recruitment of TRAF2 (show TRAF2 Antibodies) and RIPK1 (show RIPK1 Antibodies) and promotes apoptosis.
EVER2-deficient patients display mild T-cell abnormalities: a significant increase of memory CD4 (show CD4 Antibodies)+ and effector memory CD8 (show CD8A Antibodies)+ T cells, a bias of the T cell receptor Valphabeta and Vgammadelta repertoires and an increase of skin-homing CD4 (show CD4 Antibodies)+ T-cell subsets.
study describes the presence of two previously unreported homozygous mutations in the EVER2 gene in two Italian epidermodysplasia verruciformis patients, each of whom have already developed more than 10 non-melanoma skin cancers
Epidermodysplasia verruciformis (EV) is an autosomal recessive dermatosis characterized by abnormal susceptibility to human papillomaviruses (HPVs) and a high rate of progression to squamous cell carcinoma on sun-exposed skin. EV is caused by mutations in either of two adjacent genes located on chromosome 17q25.3. Both of these genes encode integral membrane proteins that localize to the endoplasmic reticulum and are predicted to form transmembrane channels. This gene encodes a transmembrane channel-like protein with 8 predicted transmembrane domains and 3 leucine zipper motifs.
transmembrane channel-like 8
, FLJ00400 protein-like
, transmembrane channel-like protein 8-like
, epidermodysplasia verruciformis 2
, epidermodysplasia verruciformis protein 2
, transmembrane channel-like protein 8
, uncharacterized protein LOC688276
, epidermodysplasia verruciformis protein 2 homolog