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TMC8 antibody (Center)

TMC8 Reactivity: Human, Mouse, Rat WB, IHC (p), EIA Host: Rabbit Polyclonal unconjugated
Catalog No. ABIN499810
  • Target See all TMC8 Antibodies
    TMC8 (Transmembrane Channel-Like 8 (TMC8))
    Binding Specificity
    • 15
    • 7
    • 7
    • 5
    • 3
    • 1
    • 1
    • 1
    • 1
    Center
    Reactivity
    Human, Mouse, Rat
    Host
    • 42
    Rabbit
    Clonality
    • 42
    Polyclonal
    Conjugate
    • 11
    • 4
    • 3
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    This TMC8 antibody is un-conjugated
    Application
    • 34
    • 20
    • 13
    • 13
    • 4
    • 3
    • 3
    • 2
    • 2
    • 1
    Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Enzyme Immunoassay (EIA)
    Specificity
    This antibody reacts to EVER2.
    Purification
    Affinity chromatography purified via peptide column
    Immunogen
    EVER2 antibody was raised against a 14 amino acid peptide from near the center of human EVER2.
    Isotype
    IgG
    Top Product
    Discover our top product TMC8 Primary Antibody
  • Application Notes
    ELISA. Western Blt: 1 - 2 μg/mL. Immunohistochemistry.
    Other applications not tested.
    Optimal dilutions are dependent on conditions and should be determined by the user.
    Restrictions
    For Research Use only
  • Buffer
    PBS containing 0.02 % sodium azide.
    Preservative
    Sodium azide
    Precaution of Use
    This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Storage
    4 °C
    Storage Comment
    Store the antibody undiluted at 2-8 °C.
  • Target
    TMC8 (Transmembrane Channel-Like 8 (TMC8))
    Alternative Name
    TMC8 (TMC8 Products)
    Synonyms
    EV2 antibody, EVER2 antibody, EVIN2 antibody, Ever2 antibody, mFLJ00400 antibody, transmembrane channel like 8 antibody, transmembrane channel-like 8 antibody, transmembrane channel-like gene family 8 antibody, TMC8 antibody, Tmc8 antibody
    Background
    Epidermodysplasia verruciformis (EV) is an autosomal recessive genodermatosis associated with a high risk of skin cancers resulting from a high susceptibility to infection by specific human papillomaviruses. Mutations in two homologous genes EVER1 and EVER2 cause the majority of EV cases. These two proteins form a complex and interact with the zinc transporter ZnT-1 in the endoplasmic reticulum. Cells lacking EVER2 accumulated higher levels of zinc in the nucleolus and nucleus compare to those cells with and intact EVER2 gene, indicating that one role of EVER2 is to regulate the intracellular distribution of zinc. At least three isoforms of EVER2 are known to exist, this antibody will only recognize the larger isoform. EVER2 has no cross-reactivity to EVER1.Synonyms: EVER2, EVIN2, Epidermodysplasia verruciformis protein 2, Transmembrane channel-like protein 8
    Gene ID
    147138
    UniProt
    Q8IU68
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