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Probably functions in nuclear protein import as nuclear transport receptor. Additionally we are shipping Transportin 2 Antibodies (19) and Transportin 2 Kits (10) and many more products for this protein.
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IPO3 (show SLAMF1 Proteins) binds NEMO (show IKBKG Proteins), promotes its nuclear import, and is critical for DNA damage-dependent NF-kappaB (show NFKB1 Proteins) activation.
Studies indicate potential roles of Tranportin-1 and Transportin-2 beyond protein nuclear import.
a role for the nuclear trafficking factor TRN2 (transportin 2) through HuR (show ELAVL1 Proteins) in cell death
Nuclear import of fused in sarcoma (FUS (show FUS Proteins)) is dependent on Transportin, and interference with this transport pathway leads to cytoplasmic redistribution and recruitment of fused in sarcoma (FUS (show FUS Proteins)) into stress granules.
Karyopherin beta 2B participates in mRNA export from the nucleus
Transportin-2 mediates nuclear import of HuR (show ELAVL1 Proteins) protein in vitro
The structure of Kap (show CDKN3 Proteins) beta 2 (also known as Transportin) bound to one of its substrates, the NLS (show ALDH1A2 Proteins) of hnRNP A1 (show HNRNPA1 Proteins), that we report here explains the mechanism of substrate displacement by Ran GTPase (show RAN Proteins).
Early in muscle differentiation, HuR (show ELAVL1 Proteins) is localized to the nucleus of myoblasts by active Transportin 2 (TRN2)-mediated import.
Probably functions in nuclear protein import as nuclear transport receptor. Serves as receptor for nuclear localization signals (NLS) in cargo substrates. Is thought to mediate docking of the importin/substrate complex to the nuclear pore complex (NPC) through binding to nucleoporin and the complex is subsequently translocated through the pore by an energy requiring, Ran-dependent mechanism. At the nucleoplasmic side of the NPC, Ran binds to the importin, the importin/substrate complex dissociates and importin is re-exported from the nucleus to the cytoplasm where GTP hydrolysis releases Ran. The directionality of nuclear import is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus (By similarity).
, transportin 2 (importin 3, karyopherin beta 2b)
, importin 3
, karyopherin beta 2b, transportin
, karyopherin beta-2b
, karyopherin (importin) beta 2b