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Triple Functional Domain Protein Proteins (TRIO)

Promotes the exchange of GDP by GTP. Additionally we are shipping TRIO Antibodies (7) and and many more products for this protein.

list all proteins Gene Name GeneID UniProt
TRIO 7204 O75962
Rat TRIO TRIO 310192  
Mouse TRIO TRIO 223435 Q0KL02
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Top TRIO Proteins at

Showing 2 out of 2 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
HOST_Wheat germ Human GST tag 10 μg Log in to see 9 Days
HOST_Baculovirus infected Insect Cells Human GST tag   5 μg Log in to see 10 to 12 Days

TRIO Proteins by Origin and Source

Origin Expressed in Conjugate
Human ,

More Proteins for Triple Functional Domain Protein (TRIO) Interaction Partners

Human Triple Functional Domain Protein (TRIO) interaction partners

  1. our data show the importance of spatio-temporal regulation of the actin cytoskeleton through Trio and Rac1 at VE-cadherin (show CDH5 Proteins)-based cell-cell junctions in the maintenance of the endothelial barrier.

  2. Aberrant expression of TRIO might play an important role in hepatocellular carcinoma (HCC (show FAM126A Proteins)) through promoting cell proliferation and invasion, and TRIO may be a novel therapeutic target for the treatment of HCC (show FAM126A Proteins)

  3. Strong statistical evidence for a causal role of TRIO in neurodevelopmental and neuropsychiatric disorders.

  4. TRIO controls Rac1 activation in dividing cells which counteracts MgcRacGAP (show RACGAP1 Proteins) function in cytokinesis.

  5. TRIO is an EB1 dependent MT plus end tracking protein, and forms a complex with NAV1 at growing MT ends, which regulates TRIO-mediated Rac1 activation and neurite outgrowth.

  6. Describe here an invadopodia disassembly model, where a signalling axis involving TrioGEF, Rac1, Pak1 (show PAK1 Proteins), and phosphorylation of cortactin (show CTTN Proteins), causes invadopodia dissolution.

  7. We conclude that Trio promotes leukocyte transendothelial migration by inducing endothelial docking structure formation in a filamin-dependent manner through the activation of Rac1 and RhoG.

  8. Trio, is essential for activating Rho- and Rac (show AKT1 Proteins)-regulated signaling pathways acting on JNK (show MAPK8 Proteins) and p38 (show CRK Proteins).

  9. GEF (show SLC2A4RG Proteins) Trio is responsible for lamellipodia formation through its N-terminal DH-PH domain in a Rac1-dependent manner during fibronectin (show FN1 Proteins)-mediated spreading and migration.

  10. present the x-ray structure refined to 1.7-A resolution and effect on signaling pathway by PI 3 (show PI3 Proteins)-kinase

Mouse (Murine) Triple Functional Domain Protein (TRIO) interaction partners

  1. The Trio gene regulates the neuronal development of the hippocampus and that it affects the intelligence of adult mice.

  2. Trio may serve as a a signal integrator decoding extrinsic signals to Rho GTPases for cytoskeleton organization

  3. M-cadherin-dependent adhesion can activate Rac1 via the Rho-GEF (show ARHGEF2 Proteins) Trio at the time of myoblast fusion.

  4. the results show a link between Trio activity,Rac1 activation,neuronal organization,and recruitment of Cadherin-11 receptor to form a complex with Trio in hindbrain embryology.

  5. findings establish Trio as a guanine nucleotide exchange factor that mediates netrin-1 signaling in axon outgrowth and guidance through its ability to activate Rac1

TRIO Protein Profile

Protein Summary

Promotes the exchange of GDP by GTP. Together with leukocyte antigen-related (LAR) protein, it could play a role in coordinating cell-matrix and cytoskeletal rearrangements necessary for cell migration and cell growth.

Gene names and symbols associated with TRIO

  • trio Rho guanine nucleotide exchange factor (TRIO)
  • trio Rho guanine nucleotide exchange factor (Trio)
  • triple functional domain (PTPRF interacting) (Trio)
  • triple functional domain (PTPRF interacting) (trio)
  • 6720464I07Rik protein
  • AA408740 protein
  • ARHGEF23 protein
  • si:dz230d15.1 protein
  • Solo protein
  • tgat protein

Protein level used designations for TRIO

PTPRF-interacting protein , triple functional domain (PTPRF interacting) , triple functional domain protein

7204 Homo sapiens
310192 Rattus norvegicus
223435 Mus musculus
368847 Danio rerio
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