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May play a role in the polymerization of tubulin into microtubules, microtubule bundling and the stabilization of existing microtubules, thus maintaining the integrity of the microtubule network. Additionally we are shipping Tppp Antibodies (78) and Tppp Proteins (7) and many more products for this protein.
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the central folded domain of TPPP/p25 following binding to microtubules can drive s homotypic protein-protein interactions leading to bundled microtubules.
Results reveal a link between p25 (show LCN2 ELISA Kits) and BACE1 (show BACE ELISA Kits) in Alzheimer disease (AD) brains and suggest that upregulated Cdk5 (show CDK5 ELISA Kits) activation by p25 (show LCN2 ELISA Kits) accelerates AD pathogenesis by enhancing BACE1 (show BACE ELISA Kits) activity via phosphorylation.
Epigenetic changes in TPPP, in combination with experiences of maltreatment, may confer risk for depression in children.
suggest that the zinc as a specific divalent cation could be involved in the fine-tuning of the physiological TPPP/p25 level counteracting both the enrichment and the lack of this protein leading to distinct central nervous system diseases
results suggest that ROCK regulates beta-catenin stability in cells via preventing TPPP1-mediated inhibition of HDAC6 activity, to reduce its acetylation and degradation via phosphorylation by CK1 and GSK3beta
GSK3 promotes the mitochondrial translocation of p53 (show TP53 ELISA Kits), enabling its interaction with Bcl2 (show BCL2 ELISA Kits) to allow Bax (show BAX ELISA Kits) oligomerization and the subsequent release of cytochrome C (show CYCS ELISA Kits).
dual Rock and Cdk (show CDK4 ELISA Kits) phosphorylation of Tppp1 inhibits its regulation of the cell cycle to increase cell proliferation
The RhoA (show RHOA ELISA Kits)-ROCK-LIMK2 (show LIMK2 ELISA Kits)-TPPP pathway controls metaphase spindle-orientation; TPPP colocalizes with LIMK2 (show LIMK2 ELISA Kits) at the mitotic spindle.
Although serine-129 phosphorylation of alpha-synuclein (show SNCA ELISA Kits) facilitates TPPP-mediated alpha-SYN oligomerization, this modification does not seem to play an inevitable role in the early step of alpha-SYN oligomer formation in a cellular model of multiple system atrophy.
The authors conclude that the modest structural changes that p25alpha undergoes can promote weak intermolecular contacts and that polyanions such as heparin play a central role in stabilizing these aggregates.
These results support an essential role for TPPP/p25 in oligodendrocyte differentiation likely via rearrangement of the microtubule system during the process elongation prior to the onset of myelination.
LIMK1 phosphorylation of p25 blocks p25 activity, thus promoting microtubule disassembly.
A pathway was discovered by which p25 (show CDK5R1 ELISA Kits) and cdk5 (show CDK5 ELISA Kits) increases the amyloidogenic processing of amyloid precursor protein (show APP ELISA Kits).
May play a role in the polymerization of tubulin into microtubules, microtubule bundling and the stabilization of existing microtubules, thus maintaining the integrity of the microtubule network. May play a role in mitotic spindle assembly and nuclear envelope breakdown.
brain-specific protein p25 alpha
, 25 kDa brain-specific protein
, brain specific protein p25 alpha
, glycogen synthase kinase 3 (GSK3) inhibitor p24
, tubulin polymerization-promoting protein
, tubulin polymerization promoting protein p25 alpha