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Two Pore Segment Channel 1 Proteins (TPCN1)

Voltage-gated Ca(2+) and Na+ channels have 4 homologous domains, each containing 6 transmembrane segments, S1 to S6. Additionally we are shipping Two Pore Segment Channel 1 Antibodies (15) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
TPCN1 252972 Q9EQJ0
TPCN1 53373 Q9ULQ1
TPCN1 246215 Q9WTN5
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Top Two Pore Segment Channel 1 Proteins at antibodies-online.com

Showing 5 out of 9 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
HOST_Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
Insect Cells Human rho-1D4 tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 0.5 mg Log in to see 59 to 64 Days
$8,623.45
Details
HOST_Escherichia coli (E. coli) Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
Insect Cells Mouse rho-1D4 tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 0.25 mg Log in to see 59 to 64 Days
$6,052.17
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HOST_Escherichia coli (E. coli) Human Un-conjugated   5 applications Log in to see 1 to 2 Days
$312.71
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TPCN1 Proteins by Origin and Source

Origin Expressed in Conjugate
Mouse (Murine) ,
,
Human ,
,
Rat (Rattus)

More Proteins for Two Pore Segment Channel 1 (TPCN1) Interaction Partners

Arabidopsis thaliana Two Pore Segment Channel 1 (TPCN1) interaction partners

  1. crystal structure of TPC1 from Arabidopsis thaliana at 2.87 A resolution as a basis for understanding ion permeation, channel activation, the location of voltage-sensing domains and regulatory ion-binding sites

  2. crystal structure of a vacuolar two-pore channel from Arabidopsis thaliana, AtTPC1, which functions as a homodimer

  3. The SV channel fou2 mutation in TCP1 altered sensitivity to luminal Ca2 (show CA2 Proteins)+ levels.

  4. TPC1 contains a N-terminal dileucine motif (EDPLI) critical for vacuolar targeting

  5. TPC1 has a role in maintaining differential K and Ca storage across the leaf; it releases Ca2 (show CA2 Proteins)+ from epidermal and bundle sheath cell vacuoles to maintain low [Ca]vac.

  6. EF-hand 1 (show HAND1 Proteins) modulates the Ca2 (show CA2 Proteins)+-sensitivity of TPC1, whereas EF-hand 2 (show HAND2 Proteins) is essential for the Ca2 (show CA2 Proteins)+-dependent channel opening.

  7. Results indicate that Glu (show DCTN1 Proteins)-450 and Asp (show ASIP Proteins)-454 of the slow vacuolar channel TPC1 are directly involved in Ca2 (show CA2 Proteins)+ binding, whereas Glu (show DCTN1 Proteins)-456 and Glu (show DCTN1 Proteins)-457 are probably involved in connecting the luminal Ca2 (show CA2 Proteins)+ binding site to the channel gate.

  8. AtTPC1 functions in response to external Ca2 (show CA2 Proteins)+ but not to abscisic acid and methyl jasmonate in Arabidopsis guard cells.

  9. Results suggest that members of TPC1 channel family are reactive oxygen species-responsive calcium channels and are the possible targets of aluminum-dependent inhibition.

  10. a tpc1 knockout mutant lacks functional slow vacuolar channel activity and is defective in both abscisic acid-induced repression of germination and in the response of stomata to extracellular calcium

Mouse (Murine) Two Pore Segment Channel 1 (TPCN1) interaction partners

  1. Mice lacking the endo-lysosomal TPC1 were protected from myocardial ischemia reperfusion injury.

  2. Genetic ablation of endolysosomal TPC1 or TPC2 (show TPCN2 Proteins) channels attenuates glucose- and sulfonylurea-induced membrane currents, depolarization, cytoplasmic Ca2 (show CA2 Proteins)+ signals, and insulin (show INS Proteins) secretion in pancreatic beta cells.

  3. It was concluded that Tpcn1/2(-/-) mice show mature-onset obesity due to reduced lipid availability and use, and a defect in beta-adrenergic receptor signaling, leading to impaired thermogenic activity, in brown adipose tissue.

  4. Results report the existence of a novel, alternative variant isoform of Tpcn1, termed Tpcn1B, resulting from an alternative promoter and giving rise to a TPC1B protein with an N-terminal truncation relative to the sequence of the TPC1A.

  5. NAADP and the two-pore calcium channel TPC1 participate in the acrosome reaction in mammalian spermatozoa.

  6. TPC1 is a member of a new family of voltage-gated Na(+) channels that senses pH changes and confers electrical excitability to organelles.

  7. We find alterations in two-pore calcium channel protein expression, with loss of presenilin preventing the formation of a high molecular weight species of TPC1 and TPC2 (show TPCN2 Proteins).

  8. Study identifies an endolysosomal ATP-sensitive Na channel - a complex formed by two-pore channels TPC1 and TPC2 (show TPCN2 Proteins); channel complex detects nutrient status, becomes constitutively open upon nutrient removal and mTOR (show FRAP1 Proteins) translocation off the lysosomal membrane, and controls the lysosome's membrane potential, pH stability, and amino acid homeostasis.

  9. Study finds by direct patch-clamp analysis of endolysosomal membranes that PI(3,5)P2 specifically activates TPCs and, unexpectedly, that nicotinic acid adenine dinucleotide phosphate does not. TPC1 and TPC2 (show TPCN2 Proteins)-mediated currents are selective for Na+, which is the predominant cation in the lysosome.

Human Two Pore Segment Channel 1 (TPCN1) interaction partners

  1. Studies suggest that both two-pore channels TPC1 and TPC2 (show TPCN2 Proteins) as nicotinic acid adenine dinucleotide phosphate (NAADP) targets.

  2. The TPC1 was shown to interact with citron kinase, with TPC1 overexpression affecting RhoA activity and myosin light chain phosphorylation levels in cytokinesis.

  3. NAADP induced marked Ca(2 (show CA2 Proteins)+) transients in HEK293 cells that stably coexpressed hTPC2 with hTPC1 or cTPC3, but failed to evoke any such response in cells that coexpressed interacting hTPC2 and rTPC3 subunits

  4. TPC2 (show TPCN2 Proteins), but not TPC1, caused a proliferation of endolysosomal structures, dysregulating intracellular trafficking, and cellular pigmentation.

  5. TPC1 and TPC2 (show TPCN2 Proteins) proteins play a key role in Ebola virus infection and may be effective targets for antiviral therapy.

  6. NAADP triggers H+ release from lysosomes and endolysomes through activation of TPC1, but that the Ca2 (show CA2 Proteins)+ -releasing ability of TPC1 will depend on the ionic composition of the acidic stores

  7. TPC1 is a member of a new family of voltage-gated Na(+) channels that senses pH changes and confers electrical excitability to organelles.

  8. The concerted regulation of TPC1 activity by luminal Ca(2 (show CA2 Proteins)+) and by membrane potential thus provides a potential mechanism to explain NAADP-induced Ca(2 (show CA2 Proteins)+) oscillations.

  9. OsTPC1 plays a crucial role in TvX-induced Ca(2 (show CA2 Proteins)+) influx as a plasma membrane Ca(2 (show CA2 Proteins)+)-permeable channel consequently required for the regulation of phytoalexin biosynthesis

  10. Data show that human two-pore channel TPC1 is critical for nicotinic acid adenine dinucleotide phosphate action and is likely the long sought after target channel for NAADP.

Two Pore Segment Channel 1 (TPCN1) Protein Profile

Protein Summary

Voltage-gated Ca(2+) and Na+ channels have 4 homologous domains, each containing 6 transmembrane segments, S1 to S6. TPCN1 is similar to these channels, but it has only 2 domains containing S1 to S6 (Ishibashi et al., 2000

Gene names and symbols associated with TPCN1

  • two pore segment channel 1 (Tpcn1)
  • two pore calcium channel protein 1 (TPC1)
  • two pore channel 1 (Tpcn1)
  • two pore segment channel 1 (TPCN1)
  • two pore segment channel 1 (tpcn1)
  • 5730403B01Rik protein
  • ATCCH1 protein
  • ATTPC1 protein
  • CALCIUM CHANNEL 1 protein
  • FATTY ACID OXYGENATION UPREGULATED 2 protein
  • FOU2 protein
  • mKIAA1169 protein
  • si:dkey-125i10.5 protein
  • T5L23.5 protein
  • TPC1 protein
  • two-pore channel 1 protein

Protein level used designations for TPCN1

two pore calcium channel protein 1 , voltage-dependent calcium channel protein TPC1 , two-pore channel 1 , two-pore segment channel 1 , two pore channel 1 , voltage-gated Ca channel

GENE ID SPECIES
413609 Apis mellifera
825655 Arabidopsis thaliana
252972 Mus musculus
53373 Homo sapiens
567534 Danio rerio
417033 Gallus gallus
477492 Canis lupus familiaris
246215 Rattus norvegicus
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