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U2AF Homology Motif (UHM) Kinase 1 Proteins (UHMK1)

The gene encodes a serine/threonine protein kinase that promotes cell cycle progression through G1 by phosphorylation of the cyclin-dependent kinase inhibitor 1B (p27Kip1), which causes nuclear export and degradation. Additionally we are shipping U2AF Homology Motif (UHM) Kinase 1 Antibodies (86) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
UHMK1 127933 Q8TAS1
Mouse UHMK1 UHMK1 16589 P97343
Rat UHMK1 UHMK1 246332 Q63285
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Top U2AF Homology Motif (UHM) Kinase 1 Proteins at antibodies-online.com

Showing 5 out of 6 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
HOST_Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
HOST_Wheat germ Human GST tag 10 μg Log in to see 9 Days
$405.71
Details
Yeast Pongo abelii His tag   1 mg Log in to see 56 to 66 Days
$3,166.17
Details
HOST_Baculovirus infected Insect Cells Human GST tag   50 μg Log in to see 10 to 12 Days
$570.24
Details
HOST_Human Human Un-conjugated   20 μg Log in to see 9 to 11 Days
$785.40
Details

UHMK1 Proteins by Origin and Source

Origin Expressed in Conjugate
Human , , ,
,

Top referenced U2AF Homology Motif (UHM) Kinase 1 Proteins

  1. Human UHMK1 Protein expressed in Wheat germ - ABIN1324602 : Bristow, Lane, Walker, Chen, Sei, Hyde, Kleinman, Harrison, Eastwood: Expression of kinase interacting with stathmin (KIS, UHMK1) in human brain and lymphoblasts: Effects of schizophrenia and genotype. in Brain research 2009 (PubMed)

More Proteins for U2AF Homology Motif (UHM) Kinase 1 (UHMK1) Interaction Partners

Human U2AF Homology Motif (UHM) Kinase 1 (UHMK1) interaction partners

  1. Moreover, we showed that CATS and KIS antagonize the transactivation capacity of CALM/AF10 (show MLLT10 Proteins).In summary, our results show that CATS interacts with and is a substrate for KIS, suggesting that KIS regulates CATS function

  2. The contribution of UHMK1 gene in schizophrenia susceptibility, was explored.

  3. We identify the kinase responsible for S10 phosphorylation as human kinase interacting stathmin (hKIS) and show that it regulates cell cycle progression in response to mitogens.

  4. KIS gene was overexpressed in NF1 (show NF1 Proteins)-associated plexiform neurofibromas and malignant peripheral nerve sheath tumors (MPNSTs) as compared to dermal neurofibroma which suggests a possible implication of KIS in the genesis of NF1 (show NF1 Proteins)-associated tumors.

  5. Evidence indicating that UHMK1 may be a candidate susceptibility gene for Schizophrenia in the British population. UHMK1 is situated between previously implicated genes RGS4 (show RGS4 Proteins) and NOS1AP (show NOS1AP Proteins).

  6. KIS promoter is activated by serum-responsive GABP binding to Ets (show ETS1 Proteins)-binding sites which leads to KIS gene expression, cell migration, and cell cycle progression

  7. Results show that KIS is a direct transcriptional target of FoxM1 (show FOXM1 Proteins).

  8. Overexpression of KIS protein kinase is associated with acute myelogenous leukemia, myelodysplastic syndrome and acute lymphoblastic leukemia

  9. A follow up article showing further association between markers in UHMK1 and schizophrenia in a London based sample. Association replicated in an independent Scottish sample.

  10. KIS is expressed in neurons, and its encoded protein is localised to the nucleus and cytoplasm. No difference in KIS expression was found between schizophrenics and controls or in the lymphoblast cell lines.

Mouse (Murine) U2AF Homology Motif (UHM) Kinase 1 (UHMK1) interaction partners

  1. The absence of KIS results in a significant decrease in AMPA (show GRIA3 Proteins) receptors in dendritic spines.

  2. disregulation of gene expression due to KIS inactivation affects specific brain functions.

  3. Uhmk1 was concentrated in the nucleus, but cycled rapidly between nucleus and cytosol.

  4. Endogenous mouse KIS was detected mainly in the nucleus of asynchronously growing cells. During serum starvation, its expression was reduced.

  5. KIS is a component of the molecular device that modulates translation in RNA-transporting granules as a result of local signals.

  6. Phosphorylation of p27Kip1 (show CDKN1B Proteins) by KIS leads to cell-cycle progression, whereas the target sequence and the physiological relevance of KIS-mediated stathmin (show STMN1 Proteins) phosphorylation in VSMCs

U2AF Homology Motif (UHM) Kinase 1 (UHMK1) Protein Profile

Protein Summary

The gene encodes a serine/threonine protein kinase that promotes cell cycle progression through G1 by phosphorylation of the cyclin-dependent kinase inhibitor 1B (p27Kip1), which causes nuclear export and degradation. The encoded protein is also thought to function in the adult nervous system and the gene has been associated with schizophrenia. Alternative splicing results in multiple transcript variants.

Gene names and symbols associated with UHMK1

  • U2AF homology motif (UHM) kinase 1 (UHMK1)
  • U2AF homology motif (UHM) kinase 1 (uhmk1)
  • U2AF homology motif (UHM) kinase 1 (Uhmk1)
  • 4732477C12Rik protein
  • 4930500M09Rik protein
  • AA673513 protein
  • AI449218 protein
  • AU021979 protein
  • KIS protein
  • Kist protein
  • P-CIP2 protein
  • UHMK1 protein
  • zgc:153241 protein

Protein level used designations for UHMK1

U2AF homology motif (UHM) kinase 1 , kinase interacting stathmin , serine/threonine-protein kinase Kist , serine/threonine-protein kinase Kist-like , KIS protein kinase , PAM COOH-terminal interactor protein 2 , kinase interacting with leukemia-associated gene (stathmin) , U2AF homology motif kinase 1 , kinase interacting with stathmin , P-CIP2

GENE ID SPECIES
424369 Gallus gallus
469560 Pan troglodytes
720105 Macaca mulatta
767721 Danio rerio
100058796 Equus caballus
100408720 Callithrix jacchus
100585553 Nomascus leucogenys
100622137 Sus scrofa
127933 Homo sapiens
16589 Mus musculus
478986 Canis lupus familiaris
246332 Rattus norvegicus
538770 Bos taurus
100172072 Pongo abelii
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