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The gene encodes a serine/threonine protein kinase that promotes cell cycle progression through G1 by phosphorylation of the cyclin-dependent kinase inhibitor 1B (p27Kip1), which causes nuclear export and degradation. Additionally we are shipping U2AF Homology Motif (UHM) Kinase 1 Antibodies (84) and many more products for this protein.
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Human UHMK1 Protein expressed in Wheat germ - ABIN1324602
Bristow, Lane, Walker, Chen, Sei, Hyde, Kleinman, Harrison, Eastwood: Expression of kinase interacting with stathmin (KIS, UHMK1) in human brain and lymphoblasts: Effects of schizophrenia and genotype. in Brain research 2009
Moreover, we showed that CATS and KIS antagonize the transactivation capacity of CALM/AF10 (show MLLT10 Proteins).In summary, our results show that CATS interacts with and is a substrate for KIS, suggesting that KIS regulates CATS function
The contribution of UHMK1 gene in schizophrenia susceptibility, was explored.
We identify the kinase responsible for S10 phosphorylation as human kinase interacting stathmin (hKIS) and show that it regulates cell cycle progression in response to mitogens.
KIS gene was overexpressed in NF1 (show NF1 Proteins)-associated plexiform neurofibromas and malignant peripheral nerve sheath tumors (MPNSTs) as compared to dermal neurofibroma which suggests a possible implication of KIS in the genesis of NF1 (show NF1 Proteins)-associated tumors.
Evidence indicating that UHMK1 may be a candidate susceptibility gene for Schizophrenia in the British population. UHMK1 is situated between previously implicated genes RGS4 (show RGS4 Proteins) and NOS1AP (show NOS1AP Proteins).
KIS promoter is activated by serum-responsive GABP binding to Ets (show ETS1 Proteins)-binding sites which leads to KIS gene expression, cell migration, and cell cycle progression
Results show that KIS is a direct transcriptional target of FoxM1 (show FOXM1 Proteins).
Overexpression of KIS protein kinase is associated with acute myelogenous leukemia, myelodysplastic syndrome and acute lymphoblastic leukemia
A follow up article showing further association between markers in UHMK1 and schizophrenia in a London based sample. Association replicated in an independent Scottish sample.
KIS is expressed in neurons, and its encoded protein is localised to the nucleus and cytoplasm. No difference in KIS expression was found between schizophrenics and controls or in the lymphoblast cell lines.
The absence of KIS results in a significant decrease in AMPA (show GRIA3 Proteins) receptors in dendritic spines.
disregulation of gene expression due to KIS inactivation affects specific brain functions.
Uhmk1 was concentrated in the nucleus, but cycled rapidly between nucleus and cytosol.
Endogenous mouse KIS was detected mainly in the nucleus of asynchronously growing cells. During serum starvation, its expression was reduced.
KIS is a component of the molecular device that modulates translation in RNA-transporting granules as a result of local signals.
Phosphorylation of p27Kip1 (show CDKN1B Proteins) by KIS leads to cell-cycle progression, whereas the target sequence and the physiological relevance of KIS-mediated stathmin (show STMN1 Proteins) phosphorylation in VSMCs
The gene encodes a serine/threonine protein kinase that promotes cell cycle progression through G1 by phosphorylation of the cyclin-dependent kinase inhibitor 1B (p27Kip1), which causes nuclear export and degradation. The encoded protein is also thought to function in the adult nervous system and the gene has been associated with schizophrenia. Alternative splicing results in multiple transcript variants.
U2AF homology motif (UHM) kinase 1
, kinase interacting stathmin
, serine/threonine-protein kinase Kist
, serine/threonine-protein kinase Kist-like
, KIS protein kinase
, PAM COOH-terminal interactor protein 2
, kinase interacting with leukemia-associated gene (stathmin)
, U2AF homology motif kinase 1
, kinase interacting with stathmin