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anti-UDP Glucuronosyltransferase 1 Family, Polypeptide A1 (UGT1A1) Antibodies

UGT1A1 encodes a UDP-glucuronosyltransferase, an enzyme of the glucuronidation pathway that transforms small lipophilic molecules, such as steroids, bilirubin, hormones, and drugs, into water-soluble, excretable metabolites. Additionally we are shipping UGT1A1 Kits (11) and UGT1A1 Proteins (3) and many more products for this protein.

list all antibodies Gene Name GeneID UniProt
UGT1A1 54658 P22309
UGT1A1 394436 Q63886
UGT1A1 24861 Q64550
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Top anti-UGT1A1 Antibodies at antibodies-online.com

Showing 10 out of 38 products:

Catalog No. Reactivity Host Conjugate Application Images Quantity Supplier Delivery Price Details
Human Rabbit Un-conjugated WB 100 μL Log in to see 2 to 3 Days
$289.00
Details
Dog Rabbit Un-conjugated WB 100 μL Log in to see 2 to 3 Days
$229.00
Details
Human Rabbit Un-conjugated IF, IHC (p), WB UGT1A1 Antibody (N-term) (ABIN657870) western blot analysis in HepG2 cell line lysates (35 µg/lane). This demonstrates the UGT1A1 antibody detected the UGT1A1 protein (arrow). 400 μL Log in to see 10 to 11 Days
$324.50
Details
Human Rabbit Un-conjugated WB 50 μg Log in to see 8 to 10 Days
$551.83
Details
Human Rabbit Un-conjugated ELISA, WB 100 μg Log in to see 2 to 3 Days
$343.75
Details
Human Rabbit Un-conjugated WB 100 μg Log in to see 8 to 10 Days
$493.17
Details
Human Rabbit Un-conjugated IF, IHC, WB 100 μL Log in to see 14 Days
$323.13
Details
Human Rabbit Un-conjugated WB Western blot analysis of UGT1A1 expression in HepG2 (A), SHSY5Y (B), mouse liver (C), rat liver (D) whole cell lysates. 200 μL Log in to see 9 Days
$487.50
Details
Human Rabbit Un-conjugated WB UGT1A1 antibody used at 2.5 ug/ml to detect target protein. 100 μg Log in to see 3 to 4 Days
$388.93
Details
Human Rabbit Un-conjugated IF, IHC, WB 400 μL Log in to see 6 Days
$415.58
Details

UGT1A1 Antibodies by Reactivity, Application, Clonality and Conjugate

Attributes Applications Host Clonality Conjugate
Human , ,
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Mouse (Murine)


Rat (Rattus)


Top referenced anti-UGT1A1 Antibodies

  1. Human Polyclonal UGT1A1 Primary Antibody for WB - ABIN2781804 : Braun, Richman, Quirke, Daly, Adlard, Elliott, Barrett, Selby, Meade, Stephens, Parmar, Seymour: Predictive biomarkers of chemotherapy efficacy in colorectal cancer: results from the UK MRC FOCUS trial. in Journal of clinical oncology : official journal of the American Society of Clinical Oncology 2008 (PubMed)

  2. Human Polyclonal UGT1A1 Primary Antibody for IF, IHC (p) - ABIN657870 : Italia, Jijina, Jain, Merchant, Nadkarni, Mukherjee, Ghosh, Colah: The effect of UGT1A1 promoter polymorphism on bilirubin response to hydroxyurea therapy in hemoglobinopathies. in Clinical biochemistry 2010 (PubMed)

  3. Dog (Canine) Polyclonal UGT1A1 Primary Antibody for WB - ABIN2781805 : Wasmuth, Keppeler, Herrmann, Schirin-Sokhan, Barker, Lammert: Coinheritance of Gilbert syndrome-associated UGT1A1 mutation increases gallstone risk in cystic fibrosis. in Hepatology (Baltimore, Md.) 2006 (PubMed)

More Antibodies against UGT1A1 Interaction Partners

Human UDP Glucuronosyltransferase 1 Family, Polypeptide A1 (UGT1A1) interaction partners

  1. The frequency of the UGT1A1*6 allele was significantly higher in breast cancer and gastrointestinal cancer patients than that in healthy females.

  2. Our findings demonstrate that UGT1A1 (TA)n polymorphism is not the only factor triggering gallstone formation in SCD (show SCD Antibodies). Cholelithiasis is also modulated by RET (show RET Antibodies) count, the number of deleted alpha-genes, HU therapy and the frequency of vaso-occlusive events.

  3. The genotype frequencies for the UGT1A1 polymorphism at position -211 were associated with the histological type of gastric cancer, in which patients with GG genotype showed a predisposition to developing tubular adenocarcinoma. In addition, polymorphisms at positions *28 and -3156 were correlated with the depth of invasion where patients carrying 6TAA or G allele tended to have a local invasion.

  4. The serum bilirubin levels seem to be affected by the homozygosity or heterozygosity of the UGT1A1 gene mutation; 211G>A homozygous mutation is an important factor that causes a rise in bilirubin in neonates with unconjugated hyperbilirubinemia

  5. Dimerization changed the chemical regioselectivity, substrate-binding affinity, and enzymatic activity of UGT1A1 and UGT1A9 (show UGT1A9 Antibodies) in glucuronidation of quercetin.

  6. novel genetic score model improved the predictive value of UGT1A1 on SIRD. If validated, it will provide valuable information for clinical use of irinotecan

  7. There were not statistical significant differences between carriers of KRAS mutated alleles between SD and PD groups. No significant difference was found between response rates and toxicity and DPD (show DPYD Antibodies) or UGT1A1 genotypes. Our results suggested that determination of DPD (show DPYD Antibodies) or UGT1A1 genotypes could not be useful for predicting severe toxicity of irinotecan in our population.

  8. Belinostat AUC was increased (P = .003), and t1/2 increased (P = .0009) in UGT1A1*28 and UGT1A1*60 carriers.

  9. Both UGT1A1(*)28 and (*)6 polymorphisms may have an increased risk of irinotecan-induced neutropenia.

  10. A difference in belinostat clearance based on UGT1A1 genotype.

Mouse (Murine) UDP Glucuronosyltransferase 1 Family, Polypeptide A1 (UGT1A1) interaction partners

  1. data confirm that Ugt1a proteins are present and active in preimplantation murine embryos and point to a potential role for these proteins in implantation and early embryonic and fetal development

  2. Intestinal induction of the UGT1A1 gene may serve to limit toxicity and improve the efficacy associated with CPT (show DHDDS Antibodies)-11 colorectal cancer treatment.

  3. Data observed that OSM (show OSM Antibodies) positively augmented the CAR and UGT1A1 expressions and CAR-mediated signaling in vivo and in vitro, through cross talk between the nuclear CAR receptor and the plasma membrane OSM (show OSM Antibodies) receptor, via the MAPK (show MAPK1 Antibodies) cascade.

  4. suppression of AhR (show AHR Antibodies) signaling pathway is associated with the down-regulation of Ugt1a mRNA during urinary bladder carcinogenesis.

  5. Nrf2 (show NFE2L2 Antibodies)-Keap1 (show KEAP1 Antibodies)-dependent UGT1A1 induction by prooxidants might represent a key adaptive response to cellular oxidative stress

  6. the loss of UGT1A function in Ugt1(-/-) mice leads to a metabolic syndrome that can serve as a model to further investigate the toxicities associated with unconjugated bilirubin and the impact of this disease in humans.

UGT1A1 Antigen Profile

Protein Summary

This gene encodes a UDP-glucuronosyltransferase, an enzyme of the glucuronidation pathway that transforms small lipophilic molecules, such as steroids, bilirubin, hormones, and drugs, into water-soluble, excretable metabolites. This gene is part of a complex locus that encodes several UDP-glucuronosyltransferases. The locus includes thirteen unique alternate first exons followed by four common exons. Four of the alternate first exons are considered pseudogenes. Each of the remaining nine 5' exons may be spliced to the four common exons, resulting in nine proteins with different N-termini and identical C-termini. Each first exon encodes the substrate binding site, and is regulated by its own promoter. The preferred substrate of this enzyme is bilirubin, although it also has moderate activity with simple phenols, flavones, and C18 steroids. Mutations in this gene result in Crigler-Najjar syndromes types I and II and in Gilbert syndrome.

Gene names and symbols associated with UGT1A1

  • UDP glucuronosyltransferase 1 family, polypeptide A1 (UGT1A1) antibody
  • UDP glucuronosyltransferase 1 family polypeptide A1 (LOC100125517) antibody
  • UDP glucuronosyltransferase 1 family, polypeptide A1 (LOC100226997) antibody
  • UDP glucuronosyltransferase 1 family, polypeptide A1 (LOC100229734) antibody
  • UDP glucuronosyltransferase 1 family, polypeptide A1 (Ugt1a1) antibody
  • BILIQTL1 antibody
  • Gnt1 antibody
  • HUG-BR1 antibody
  • Udpgt antibody
  • Udpgt-1a antibody
  • UDPGT 1-1 antibody
  • Ugt1 antibody
  • UGT1A antibody
  • UGT1A01 antibody
  • UgtBr1 antibody

Protein level used designations for UGT1A1

UDP glucuronosyltransferase 1 family, polypeptide A1 , UDP-glucuronosyltransferase 1A1 , uridine diphosphate glucuronosyltransferase 1A1 , UDP-glucuronosyltransferase 1-1 , UDP glycosyltransferase 1 family, polypeptide A1 , UDP-glucuronosyltransferase UGT1A01 , UDP glucuronosyltransferase 1 family polypeptide A1 , UDP glycosyl transferase 1A1 , UDP-glucuronosyltransferase 1-1-like , UDP-glucuronosyltransferase 1-A , UGT-1A , UGT1*1 , UGT1-01 , UGT1.1 , bilirubin UDP-glucuronosyltransferase 1-1 , bilirubin UDP-glucuronosyltransferase isozyme 1 , bilirubin-specific UDPGT isozyme 1 , UDP-glucuronosyltransferase 1 family, member 1 , UDP-glucuronosyltransferase 1 family, polypeptide A1 , UDPGT , B1 , UDP-glucuronosyltransferase 1 family member 1

GENE ID SPECIES
449596 Pan troglodytes
493955 Felis catus
574210 Macaca mulatta
751790 Bos taurus
100065342 Equus caballus
100125517 Oryzias latipes
100126701 Papio anubis
100226997 Taeniopygia guttata
100229734 Taeniopygia guttata
100405984 Callithrix jacchus
100511479 Sus scrofa
100534644 Ovis aries
54658 Homo sapiens
394436 Mus musculus
24861 Rattus norvegicus
Selected quality suppliers for anti-UGT1A1 (UGT1A1) Antibodies
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