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UDP-Galactose-4-Epimerase Proteins (GALE)

GALE encodes UDP-galactose-4-epimerase which catalyzes two distinct but analogous reactions: the epimerization of UDP-glucose to UDP-galactose, and the epimerization of UDP-N-acetylglucosamine to UDP-N-acetylgalactosamine. Additionally we are shipping GALE Antibodies (69) and GALE Kits (3) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
GALE 74246 Q8R059
GALE 2582 Q14376
GALE 114860  
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Top GALE Proteins at antibodies-online.com

Showing 10 out of 26 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
HOST_Escherichia coli (E. coli) Human His tag 100 μg Log in to see 2 to 3 Days
$217.80
Details
HOST_Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
HOST_Escherichia coli (E. coli) Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
HOST_Escherichia coli (E. coli) Human His tag 100 μg Log in to see 7 to 8 Days
$286.00
Details
HOST_Escherichia coli (E. coli) Human His-SUMO Tag 50 μg Log in to see 21 to 26 Days
$341.00
Details
HOST_Wheat germ Human GST tag 10 μg Log in to see 9 Days
$405.71
Details
Yeast Streptomyces lividans His tag   1 mg Log in to see 56 to 66 Days
$2,887.50
Details
Yeast Streptococcus thermophilus His tag   1 mg Log in to see 56 to 66 Days
$2,896.67
Details
Yeast REACT_Streptococcus mutans His tag   1 mg Log in to see 56 to 66 Days
$2,898.50
Details
Yeast REACT_Yersinia enterocolitica His tag   1 mg Log in to see 56 to 66 Days
$2,907.67
Details

GALE Proteins by Origin and Source

Origin Expressed in Conjugate
Mouse (Murine)

Human , ,
, ,
Rat (Rattus)

Top referenced GALE Proteins

  1. Human GALE Protein expressed in Escherichia coli (E. coli) - ABIN667033 : Holden, Rayment, Thoden: Structure and function of enzymes of the Leloir pathway for galactose metabolism. in The Journal of biological chemistry 2003 (PubMed)
    Show all 2 references for ABIN667033

  2. Human GALE Protein expressed in Escherichia coli (E. coli) - ABIN2181138 : Schulz, Watson, Sanders, Ross, Thoden, Holden, Fridovich-Keil: Determinants of function and substrate specificity in human UDP-galactose 4'-epimerase. in The Journal of biological chemistry 2004 (PubMed)
    Show all 2 references for ABIN2181138

More Proteins for UDP-Galactose-4-Epimerase (GALE) Interaction Partners

Arabidopsis thaliana UDP-Galactose-4-Epimerase (GALE) interaction partners

  1. This data from this study indicate the importance of UDP-D-galactose synthesis by UGE4 for the organization and function of endomembranes, especially TGN (show TG Proteins)/EEs, which are a sorting station of the secretory and vacuolar pathways.

  2. Rough mapping and whole-genome sequencing identified the mutant with altered localization of NIP5;1 as an allele of UDP-glucose 4-epimerase 4.

  3. RHD1, a UDP-glucose-4-epimerase, is a likely target of root-specific negative regulation by ethylene and that loss of RHD1 function results in a heightened sensitivity of root tissues to both ethylene and auxin. [RHD1]

  4. UGE2 and UGE4 influence growth and cell wall carbohydrate biosynthesis throughout the plant, UGE3 is specialized for pollen development, and UGE1 and UGE5 might act in stress situations.

Mouse (Murine) UDP-Galactose-4-Epimerase (GALE) interaction partners

  1. results provide evidence that the Xbp1s/GalE pathway functions as a novel regulatory nexus connecting the UPR to the characteristic postprandial metabolic changes in hepatocytes.

Human UDP-Galactose-4-Epimerase (GALE) interaction partners

  1. Data show the protein structure of GALE and its substrate binding and specificity. It is mutated in type III galactosemia. [review]

  2. human UDP-galactose 4'-epimerase stability is increased by variants associated with type III galactosemia but decreased by substrate and cofactor binding

  3. These data indicated a critical role of GALE in maintaining cartilage homeostasis, and suggested that GALE inhibition might contribute to OA progress.

  4. GALE variants can be arranged into three groups depending on the severity of enzyme impairment.

  5. Resulst describe the relationship among UDP-galactose 4'-epimerase activity, substrate specificity, metabolic balance, and galactose sensitivity in mammalian cells.

  6. Subtle biochemical and metabolic abnormalities detected in patients expressing these GALE alleles likely reflect, at least in part, the reduced enzymatic activity of the encoded GALE proteins.

  7. Our observations show that altered protein stability is due to misfolding and that loss or reduction of enzyme activity is responsible for the molecular defects underlying GALE-deficiency galactosemia.

GALE Protein Profile

Protein Summary

This gene encodes UDP-galactose-4-epimerase which catalyzes two distinct but analogous reactions: the epimerization of UDP-glucose to UDP-galactose, and the epimerization of UDP-N-acetylglucosamine to UDP-N-acetylgalactosamine. The bifunctional nature of the enzyme has the important metabolic consequence that mutant cells (or individuals) are dependent not only on exogenous galactose, but also on exogenous N-acetylgalactosamine as a necessary precursor for the synthesis of glycoproteins and glycolipids. Mutations in this gene result in epimerase-deficiency galactosemia, also referred to as galactosemia type 3, a disease characterized by liver damage, early-onset cataracts, deafness and mental retardation, with symptoms ranging from mild ('peripheral' form) to severe ('generalized' form). Multiple alternatively spliced transcripts encoding the same protein have been identified.

Gene names and symbols associated with GALE

  • UDP-galactose-4-epimerase (GALE)
  • UDP-galactose-4-epimerase (gale)
  • UDP-glucose 4-epimerase (RHD1)
  • UDP-galactose-4-epimerase (ECs0787)
  • UDP-galactose-4-epimerase (galE)
  • UDP-galactose 4-epimerase GalE (galE)
  • UDP-glucose 4-epimerase (galE-1)
  • UDP-glucose 4-epimerase (galE-2)
  • UDP-glucose 4-epimerase (galE)
  • UDP-galactose-4-epimerase (SG0897)
  • UDP-galactose-4-epimerase (galD)
  • UDP-galactose-4-epimerase (Ent638_1250)
  • galactose-4-epimerase, UDP (Gale)
  • UDP-galactose-4-epimerase (Gale)
  • 1n569 protein
  • 2310002A12Rik protein
  • AI323962 protein
  • BA5505 protein
  • BA5700 protein
  • ECK0748 protein
  • F15H21.11 protein
  • F15H21_11 protein
  • galD protein
  • galE protein
  • im:7147391 protein
  • JW0742 protein
  • REB1 protein
  • ROOT EPIDERMAL BULGER1 protein
  • ROOT HAIR DEFECTIVE 1 protein
  • SDR1E1 protein
  • SMU.888 protein
  • UDP-GLUCOSE 4-EPIMERASE protein
  • UGE4 protein
  • VFA0352 protein
  • wu:fb05f01 protein
  • xgale protein
  • zgc:136578 protein

Protein level used designations for GALE

UDP-galactose-4-epimerase , UDP-glucose 4-epimerase , fb05f01 , UDP-galactose 4-epimerase , galactowaldenase , UDP-glucose (37.7 kD) (1N569) , UDP galactose-4'-epimerase , galactose-4-epimerase, UDP- , short chain dehydrogenase/reductase family 1E, member 1 , galactose-4-epimerase, UDP

GENE ID SPECIES
419686 Gallus gallus
456623 Pan troglodytes
678540 Danio rerio
842752 Arabidopsis thaliana
917525 Escherichia coli O157:H7 str. Sakai
945354 Escherichia coli str. K-12 substr. MG1655
957904 Escherichia coli O157:H7 str. EDL933
1028251 Streptococcus mutans UA159
1036650 Escherichia coli CFT073
1067209 Salmonella enterica subsp. enterica serovar Typhi str. Ty2
1085150 Bacillus anthracis str. Ames
1085447 Bacillus anthracis str. Ames
1147990 Yersinia pestis KIM10+
1169457 Shewanella oneidensis MR-1
1173989 Yersinia pestis CO92
1247256 Salmonella enterica subsp. enterica serovar Typhi str. CT18
1252296 Salmonella enterica subsp. enterica serovar Typhimurium str. LT2
2687202 Geobacter sulfurreducens PCA
2763289 Yersinia pestis biovar Microtus str. 91001
2883164 Pectobacterium atrosepticum SCRI1043
2955669 Yersinia pseudotuberculosis IP 32953
3103661 Methylococcus capsulatus str. Bath
3231780 Campylobacter jejuni RM1221
3280601 Vibrio fischeri ES114
3728483 Carboxydothermus hydrogenoformans Z-2901
3779874 Shigella boydii Sb227
3868345 Sodalis glossinidius str. 'morsitans'
4714920 Yersinia enterocolitica subsp. enterocolitica 8081
5114212 Enterobacter sp. 638
74246 Mus musculus
380596 Xenopus laevis
2582 Homo sapiens
523154 Bos taurus
114860 Rattus norvegicus
487373 Canis lupus familiaris
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