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GALNT6 encodes a member of the UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase (GalNAc-T) family of enzymes. Additionally we are shipping GALNT6 Antibodies (60) and many more products for this protein.
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This paper describes the identification and cloning of the orthologous human enzyme of mouse UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 6.
GalNAcT6 role in cancer [review]
Findings show that the expression of GalNAc-T6 in endometrial carcinoma is significantly related to E-cadherin (show CDH1 Proteins) expression, and better prognosis and overall survival.
Study showed that GalNAc-T6 expression in epithelial ovarian carcinoma was different according to pathological type. In low-grade serous carcinoma, GalNAc-T6 expression may contribute to improved long-term survival.
GALNT6-induced O-glycosylation is critical for the stability, subcellular localization, and anti-apoptotic function of GRP78 (show HSPA5 Proteins) protein in cancer cells. We also suggest that GRP78 (show HSPA5 Proteins) might enhance the activity of GALNT6 in carcinogenesis through driving Golgi-to-ER relocation of GALNT6.
knockdown of GALNT6 caused drastic morphological changes of pancreatic cells, accompanied with the cadherin switching from P-cadherin to E-cadherin (show CDH1 Proteins).
Role of N-acetylgalactosaminyltransferase (show B4GALNT2 Proteins) 6 in early tumorigenesis and formation of metastasis.
These data suggest that excess O-glycosylation on APP (show APP Proteins) by GalNAc-T6 inhibits Abeta (show APP Proteins) production.
GALNT6-fibronectin (show FN1 Proteins) pathway should be a critical component for breast cancer development and progression.
Expression of ppGalNAc-T6 is significantly higher in breast cancer compared to 'normal'/benign breast tissue samples. ST6GalNAc-I (show ST6GALNAC1 Proteins) expression in breast cancer is associated with better prognosis.
These enzymes, xGalNAc-T6 and xGalNAc- T16 (show FBLN3 Proteins), from different branches of the N-acetylgalactosaminyltransferase (show B4GALNT2 Proteins) do not only display differential substrate specificities, but also specific and distinct expression pattern and biological activities in vivo.
This gene encodes a member of the UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase (GalNAc-T) family of enzymes. GalNAc-Ts initiate mucin-type O-linked glycosylation in the Golgi apparatus by catalyzing the transfer of GalNAc to serine and threonine residues on target proteins. They are characterized by an N-terminal transmembrane domain, a stem region, a lumenal catalytic domain containing a GT1 motif and Gal/GalNAc transferase motif, and a C-terminal ricin/lectin-like domain. GalNAc-Ts have different, but overlapping, substrate specificities and patterns of expression. The encoded protein is capable of glycosylating fibronectin peptide in vitro and is expressed in a fibroblast cell line, indicating that it may be involved in the synthesis of oncofetal fibronectin.
polypeptide N-acetylgalactosaminyltransferase 6
, UDP-GalNAc:polypeptide N-acetylgalactosaminyltransferase 6
, polypeptide GalNAc transferase 6
, pp-GaNTase 6
, protein-UDP acetylgalactosaminyltransferase 6
, N-acetylgalactosaminyltransferase T-6
, Protein-UDP acetylgalactosaminyltransferase 6
, UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 6
, GalNAc transferase 6
, UDP-N-acetyl-alpha-D-galactosamine: polypeptide N-acetylgalactosaminyltransferase 6