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anti-UV Radiation Resistance Associated Gene (UVRAG) Antibodies

UVRAG complements the ultraviolet sensitivity of xeroderma pigmentosum group C cells and encodes a protein with a C2 domain. Additionally we are shipping UVRAG Proteins (3) and many more products for this protein.

list all antibodies Gene Name GeneID UniProt
UVRAG 361609  
UVRAG 7405 Q9P2Y5
UVRAG 78610  
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Top anti-UVRAG Antibodies at antibodies-online.com

Showing 10 out of 92 products:

Catalog No. Reactivity Host Conjugate Application Images Quantity Supplier Delivery Price Details
Hamster Mouse Un-conjugated IP, WB 0.1 mg Log in to see 6 to 8 Days
$313.50
Details
Human Rabbit Un-conjugated IHC (p), WB Western blot analysis of anti-hUVRAG (Center) Pab (ABIN388587) in mouse heart tissue lysates. hUVRAG (Center)(arrow) was detected using the purified polyclonal antibody. Formalin-fixed and paraffin-embedded human hepatocarcinoma tissue reacted with hUVRAG (Center) (ABIN388587), which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. 400 μL Log in to see 10 to 11 Days
$324.50
Details
Human Rabbit Un-conjugated IF, IHC (p), WB Western blot analysis of anti-hUVRAG (Center) Pab (ABIN388588) in mouse liver tissue lysate. hUVRAG (Center)(arrow) was detected using the purified polyclonal antibody. Immunofluorescence staining of Autophagy UVRAG antibody (ABIN388588) on Methanol-fixed HeLa cells. Data courtesy of Dr. Eeva-Liisa Eskelinen, University of Helsinki,Finland. 400 μL Log in to see 10 to 11 Days
$324.50
Details
Human Rabbit Un-conjugated IF, IHC (p), WB Immunoprecipitation and western blot analysis of anti-UVRAG Pab (ABIN388586) in 293T cells. UVRAG is immunoprecipitated (Lane 2) and detected in 293T cell transiently transfected with mouse UVRAG (Lane 1). Detection of endogenous UVRAG is shown in 293T cells (Lane 3) but is reduced by UVRAG siRNA transfection (Lane 4). Data courtesy of Dr. Hong-Gang Wang, Moffitt Cancer Center, Tampa, FL. Immunofluorescence staining of Autophagy UVRAG antibody (ABIN388586) on Methanol-fixed HeLa cells. Data courtesy of Dr. Eeva-Liisa Eskelinen, University of Helsinki,Finland. 400 μL Log in to see 10 to 11 Days
$324.50
Details
Human Rabbit Un-conjugated EIA, IF, IHC (p), IP, WB Immunofluorescence staining of Autophagy UVRAG Antibody  on Methanol-fixed HeLa cells. Data courtesy of Dr. Eeva-Liisa Eskelinen, University of Helsinki, Finland Immunoprecipitation and Western blot analysis of anti-UVRAG Antibody  in 293T cells. UVRAG is immunoprecipitated (Lane 2) and detected in 293T cell transiently transfected with Mouse UVRAG (Lane 1). Detection of endogenous UVRAG is shown in 293T cells (Lane 3) but is reduced by UVRAG siRNA transfection (Lane 4). Data courtesy of Dr. Hong-Gang Wang, Moffitt Cancer Center, Tampa, FL.Western Blot: Anti-UVRAG Antibody . Immunoprecipitation: Anti-UVRAG Antibody .   0.4 mL Log in to see 6 to 8 Days
$401.50
Details
Human Rabbit Un-conjugated WB Western blot analysis of UVRAG Antibody (C-term L555) (ABIN1882151) in Ramos cell line lysates (35 µg/lane). UVRAG (arrow) was detected using the purified Pab. 400 μL Log in to see 10 to 11 Days
$324.50
Details
Human Rabbit Un-conjugated WB 100 μg Log in to see 8 to 10 Days
$507.83
Details
Human Mouse Un-conjugated IF, ELISA, WB Detection limit for recombinant GST tagged UVRAG is 0.3 ng/ml as a capture antibody. Western Blot analysis of UVRAG expression in transfected 293T cell line by UVRAG monoclonal antibody (M04), clone 2E8.Lane 1: UVRAG transfected lysate (Predicted MW: 78.2 KDa).Lane 2: Non-transfected lysate. 100 μg Log in to see 9 Days
$430.00
Details
Human Rabbit HRP WB   100 μg Log in to see 3 to 4 Days
$444.68
Details
Human Rabbit FITC WB   100 μg Log in to see 3 to 4 Days
$449.30
Details

UVRAG Antibodies by Reactivity, Application, Clonality and Conjugate

Attributes Applications Host Clonality Conjugate
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Top referenced anti-UVRAG Antibodies

  1. Human Polyclonal UVRAG Primary Antibody for IF, IHC (p) - ABIN388586 : Liang, Feng, Ku, Dotan, Canaani, Oh, Jung: Autophagic and tumour suppressor activity of a novel Beclin1-binding protein UVRAG. in Nature cell biology 2006 (PubMed)
    Show all 10 references for ABIN388586

  2. Human Polyclonal UVRAG Primary Antibody for WB - ABIN1882151 : Vogt, Affara, Davey, Hammer, Jobling, Lau, Mitchell, Schempp, Tyler-Smith, Williams, Yen, Rappold: Report of the Third International Workshop on Y Chromosome Mapping 1997. Heidelberg, Germany, April 13-16, 1997. in Cytogenetics and cell genetics 1998 (PubMed)
    Show all 4 references for ABIN1882151

  3. Human Polyclonal UVRAG Primary Antibody for IHC (p), WB - ABIN388587 : Ionov, Nowak, Perucho, Markowitz, Cowell: Manipulation of nonsense mediated decay identifies gene mutations in colon cancer Cells with microsatellite instability. in Oncogene 2004 (PubMed)
    Show all 3 references for ABIN388587

  4. Human Polyclonal UVRAG Primary Antibody for IF, IHC (p) - ABIN388588 : Perelman, Dafni, Naiman, Eli, Yaakov, Feng, Sinha, Weber, Khodaei, Sancar, Dotan, Canaani: Molecular cloning of a novel human gene encoding a 63-kDa protein and its sublocalization within the 11q13 locus. in Genomics 1997 (PubMed)
    Show all 3 references for ABIN388588

  5. Hamster Monoclonal UVRAG Primary Antibody for IP, WB - ABIN1449295 : Liang, Feng, Ku, Oh, Jung: UVRAG: a new player in autophagy and tumor cell growth. in Autophagy 2007 (PubMed)
    Show all 2 references for ABIN1449295

  6. Human Polyclonal UVRAG Primary Antibody for EIA, IF - ABIN1449617 : Sun, Fan, Chen, Ding, Chen, Zhong: Identification of Barkor as a mammalian autophagy-specific factor for Beclin 1 and class III phosphatidylinositol 3-kinase. in Proceedings of the National Academy of Sciences of the United States of America 2008 (PubMed)

More Antibodies against UVRAG Interaction Partners

Fruit Fly (Drosophila melanogaster) UV Radiation Resistance Associated Gene (UVRAG) interaction partners

  1. The UVRAG-containing PI3K (III) complex is required for receptor downregulation through endolysosomal degradation and for the establishment of proper cell polarity in the developing wing.

  2. UVRAG-mutated heterotaxy patient cells also display highly increased Notch (show NOTCH1 Antibodies) protein levels

Human UV Radiation Resistance Associated Gene (UVRAG) interaction partners

  1. UVRAG frameshift is expressed as a truncated protein in colorectal cancer with microsatellite instability and promotes tumorigenesis. UVRAG(FS) expression renders cells more sensitive to standard chemotherapy regimen due to a DNA repair defect.

  2. HCV, by differentially inducing the expression of Rubicon (show KIAA0226 Antibodies) and UVRAG, temporally regulated the autophagic flux to enhance its replication.

  3. tubulation requires mTOR (show FRAP1 Antibodies) activity, and we identified two direct mTOR (show FRAP1 Antibodies) phosphorylation sites on UVRAG (S550 and S571) that activate VPS34 (show PIK3C3 Antibodies).

  4. Beclin 1 (show BECN1 Antibodies) and UVRAG confer protection against radiation-induced DNA DNA double strand breaks and may maintain centrosome stability in established tumor cells.

  5. Dephosphorylation of UVRAG facilitates the lysosomal degradation of epidermal growth factor receptor (EGFR (show EGFR Antibodies)), reduces EGFR (show EGFR Antibodies) signaling, and suppresses cancer cell proliferation and tumor growth.

  6. The reports that Grb2 (show GRB2 Antibodies), when in excess (show RCC1 Antibodies), interacts with ultraviolet radiation resistance-associated gene protein (UVRAG) under excess conditions of AICD-Grb2 (show GRB2 Antibodies) or Grb2 (show GRB2 Antibodies).

  7. UVRAG is required for virus entry through combinatorial interaction with the class C-Vps complex and SNAREs.

  8. Akt1 (show AKT1 Antibodies) may inhibit autophagy by decreasing UVRAG expression, which also sensitizes cancer cells to UV irradiation.

  9. in Escherichia coli-containing phagosomes of mouse macrophages, Slamf1 (show SLAMF1 Antibodies) interacts with the class III PI3K (show PIK3CA Antibodies) Vps34 (show PIK3C3 Antibodies) in a complex with Beclin-1 (show BECN1 Antibodies) and UVRAG

  10. UVRAG promotes DNA double-strand-break repair by directly binding and activating DNA-PK in nonhomologous end joining. Disruption of UVRAG increases genetic instability and sensitivity of cells to irradiation.

Mouse (Murine) UV Radiation Resistance Associated Gene (UVRAG) interaction partners

  1. Beclin 1 (show BECN1 Antibodies) regulates endosome pathways via the UVRAG-VPS34 (show PIK3C3 Antibodies) complex.

  2. EWSR1 (show EWSR1 Antibodies) is involved in the post-transcriptional regulation of Uvrag via a miRNA-dependent pathway, resulting in the deregulation of autophagy inhibition.

  3. tubulation requires mTOR (show FRAP1 Antibodies) activity, and we identified two direct mTOR (show FRAP1 Antibodies) phosphorylation sites on UVRAG (S550 and S571) that activate VPS34 (show PIK3C3 Antibodies).

  4. silencing of UVRAG significantly attenuated the antimicrobial effects of macrophages against M. tuberculosis.

  5. data provide novel insights into the control of autophagy in T cells and identify UVRAG as a new regulator of naive peripheral T-cell homeostasis.

  6. in Escherichia coli-containing phagosomes of mouse macrophages, Slamf1 (show SLAMF1 Antibodies) interacts with the class III PI3K Vps34 (show PIK3C3 Antibodies) in a complex with Beclin-1 (show BECN1 Antibodies) and UVRAG

  7. UVRAG has cytoprotective functions in the cytosol that control the localization of Bax (show BAX Antibodies) in tumor cells exposed to apoptotic stimuli

  8. through ultraviolet irradiation resistance-associated gene (UVRAG), Bif-1 (show SH3GLB1 Antibodies) interacts with Beclin 1 (show BECN1 Antibodies) and functions as a positive mediator of the class III PI(3 (show PI3 Antibodies)) kinase (PI(3 (show PI3 Antibodies))KC3).

  9. These results suggest that mammalian cells have at least two distinct class III PI3-kinase (show PIK3CA Antibodies) complexes, and that beclin 1 (show BECN1 Antibodies) interacts distinctly with mammalian Atg14 and UVRAG in two of these complexes.

UVRAG Antigen Profile

Protein Summary

This gene complements the ultraviolet sensitivity of xeroderma pigmentosum group C cells and encodes a protein with a C2 domain. The protein activates the Beclin1-PI(3)KC3 complex, promoting autophagy and suppressing the proliferation and tumorigenicity of human colon cancer cells. Chromosomal aberrations involving this gene are associated with left-right axis malformation and mutations in this gene have been associated with colon cancer.

Gene names and symbols associated with UVRAG

  • UV-resistance associated gene (Uvrag) antibody
  • UV radiation resistance associated gene (uvrag) antibody
  • UV radiation resistance associated gene (UVRAG) antibody
  • UV radiation resistance associated gene (Uvrag1) antibody
  • UV radiation resistance associated (UVRAG) antibody
  • UV radiation resistance associated gene (Uvrag) antibody
  • 9530039D02Rik antibody
  • AI648770 antibody
  • BB124205 antibody
  • CG6116 antibody
  • DHTX antibody
  • Dmel\\CG6116 antibody
  • MGC81810 antibody
  • MGC131135 antibody
  • p63 antibody
  • uvrag antibody
  • Uvrag1 antibody
  • Uvragl antibody
  • VPS38 antibody
  • zgc:56164 antibody

Protein level used designations for UVRAG

CG6116-PA , CG6116-PB , UV radiation resistance associated gene , Uvrag-PA , Uvrag-PB , UV radiation resistance-associated gene protein , UV radiation resistance associated , UV radiation resistance-associated gene protein-like , beclin 1 binding protein , disrupted in heterotaxy

GENE ID SPECIES
34735 Drosophila melanogaster
394044 Danio rerio
614285 Bos taurus
696601 Macaca mulatta
779151 Xenopus laevis
361609 Rattus norvegicus
735238 Xenopus laevis
100413829 Callithrix jacchus
100477039 Ailuropoda melanoleuca
100486296 Xenopus (Silurana) tropicalis
100544950 Meleagris gallopavo
100552937 Anolis carolinensis
100595542 Nomascus leucogenys
100051722 Equus caballus
100354086 Oryctolagus cuniculus
100443180 Pongo abelii
7405 Homo sapiens
78610 Mus musculus
419091 Gallus gallus
451430 Pan troglodytes
607998 Canis lupus familiaris
308846 Rattus norvegicus
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