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UVRAG complements the ultraviolet sensitivity of xeroderma pigmentosum group C cells and encodes a protein with a C2 domain. Additionally we are shipping UVRAG Proteins (3) and many more products for this protein.
Showing 10 out of 92 products:
Human Polyclonal UVRAG Primary Antibody for IF, IHC (p) - ABIN388586
Liang, Feng, Ku, Dotan, Canaani, Oh, Jung: Autophagic and tumour suppressor activity of a novel Beclin1-binding protein UVRAG. in Nature cell biology 2006
Show all 10 references for ABIN388586
Human Polyclonal UVRAG Primary Antibody for WB - ABIN1882151
Vogt, Affara, Davey, Hammer, Jobling, Lau, Mitchell, Schempp, Tyler-Smith, Williams, Yen, Rappold: Report of the Third International Workshop on Y Chromosome Mapping 1997. Heidelberg, Germany, April 13-16, 1997. in Cytogenetics and cell genetics 1998
Show all 4 references for ABIN1882151
Human Polyclonal UVRAG Primary Antibody for IF, IHC (p) - ABIN388588
Ionov, Nowak, Perucho, Markowitz, Cowell: Manipulation of nonsense mediated decay identifies gene mutations in colon cancer Cells with microsatellite instability. in Oncogene 2004
Show all 3 references for ABIN388588
Human Polyclonal UVRAG Primary Antibody for IHC (p), WB - ABIN388587
Perelman, Dafni, Naiman, Eli, Yaakov, Feng, Sinha, Weber, Khodaei, Sancar, Dotan, Canaani: Molecular cloning of a novel human gene encoding a 63-kDa protein and its sublocalization within the 11q13 locus. in Genomics 1997
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Hamster Monoclonal UVRAG Primary Antibody for IP, WB - ABIN1449295
Liang, Feng, Ku, Oh, Jung: UVRAG: a new player in autophagy and tumor cell growth. in Autophagy 2007
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Human Polyclonal UVRAG Primary Antibody for EIA, IF - ABIN1449617
Sun, Fan, Chen, Ding, Chen, Zhong: Identification of Barkor as a mammalian autophagy-specific factor for Beclin 1 and class III phosphatidylinositol 3-kinase. in Proceedings of the National Academy of Sciences of the United States of America 2008
The UVRAG-containing PI3K (III) complex is required for receptor downregulation through endolysosomal degradation and for the establishment of proper cell polarity in the developing wing.
UVRAG-mutated heterotaxy patient cells also display highly increased Notch (show NOTCH1 Antibodies) protein levels
UVRAG frameshift is expressed as a truncated protein in colorectal cancer with microsatellite instability and promotes tumorigenesis. UVRAG(FS) expression renders cells more sensitive to standard chemotherapy regimen due to a DNA repair defect.
HCV, by differentially inducing the expression of Rubicon (show KIAA0226 Antibodies) and UVRAG, temporally regulated the autophagic flux to enhance its replication.
tubulation requires mTOR (show FRAP1 Antibodies) activity, and we identified two direct mTOR (show FRAP1 Antibodies) phosphorylation sites on UVRAG (S550 and S571) that activate VPS34 (show PIK3C3 Antibodies).
Beclin 1 (show BECN1 Antibodies) and UVRAG confer protection against radiation-induced DNA DNA double strand breaks and may maintain centrosome stability in established tumor cells.
Dephosphorylation of UVRAG facilitates the lysosomal degradation of epidermal growth factor receptor (EGFR (show EGFR Antibodies)), reduces EGFR (show EGFR Antibodies) signaling, and suppresses cancer cell proliferation and tumor growth.
The reports that Grb2 (show GRB2 Antibodies), when in excess (show RCC1 Antibodies), interacts with ultraviolet radiation resistance-associated gene protein (UVRAG) under excess conditions of AICD-Grb2 (show GRB2 Antibodies) or Grb2 (show GRB2 Antibodies).
UVRAG is required for virus entry through combinatorial interaction with the class C-Vps complex and SNAREs.
Akt1 (show AKT1 Antibodies) may inhibit autophagy by decreasing UVRAG expression, which also sensitizes cancer cells to UV irradiation.
in Escherichia coli-containing phagosomes of mouse macrophages, Slamf1 (show SLAMF1 Antibodies) interacts with the class III PI3K (show PIK3CA Antibodies) Vps34 (show PIK3C3 Antibodies) in a complex with Beclin-1 (show BECN1 Antibodies) and UVRAG
UVRAG promotes DNA double-strand-break repair by directly binding and activating DNA-PK in nonhomologous end joining. Disruption of UVRAG increases genetic instability and sensitivity of cells to irradiation.
Beclin 1 (show BECN1 Antibodies) regulates endosome pathways via the UVRAG-VPS34 (show PIK3C3 Antibodies) complex.
EWSR1 (show EWSR1 Antibodies) is involved in the post-transcriptional regulation of Uvrag via a miRNA-dependent pathway, resulting in the deregulation of autophagy inhibition.
silencing of UVRAG significantly attenuated the antimicrobial effects of macrophages against M. tuberculosis.
data provide novel insights into the control of autophagy in T cells and identify UVRAG as a new regulator of naive peripheral T-cell homeostasis.
in Escherichia coli-containing phagosomes of mouse macrophages, Slamf1 (show SLAMF1 Antibodies) interacts with the class III PI3K Vps34 (show PIK3C3 Antibodies) in a complex with Beclin-1 (show BECN1 Antibodies) and UVRAG
UVRAG has cytoprotective functions in the cytosol that control the localization of Bax (show BAX Antibodies) in tumor cells exposed to apoptotic stimuli
through ultraviolet irradiation resistance-associated gene (UVRAG), Bif-1 (show SH3GLB1 Antibodies) interacts with Beclin 1 (show BECN1 Antibodies) and functions as a positive mediator of the class III PI(3 (show PI3 Antibodies)) kinase (PI(3 (show PI3 Antibodies))KC3).
These results suggest that mammalian cells have at least two distinct class III PI3-kinase (show PIK3CA Antibodies) complexes, and that beclin 1 (show BECN1 Antibodies) interacts distinctly with mammalian Atg14 and UVRAG in two of these complexes.
This gene complements the ultraviolet sensitivity of xeroderma pigmentosum group C cells and encodes a protein with a C2 domain. The protein activates the Beclin1-PI(3)KC3 complex, promoting autophagy and suppressing the proliferation and tumorigenicity of human colon cancer cells. Chromosomal aberrations involving this gene are associated with left-right axis malformation and mutations in this gene have been associated with colon cancer.
, UV radiation resistance associated gene
, UV radiation resistance-associated gene protein
, UV radiation resistance associated
, UV radiation resistance-associated gene protein-like
, beclin 1 binding protein
, disrupted in heterotaxy