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Ubiquilin 2 Proteins (UBQLN2)

UBQLN2 encodes an ubiquitin-like protein (ubiquilin) that shares high degree of similarity with related products in yeast, rat and frog. Additionally we are shipping Ubiquilin 2 Antibodies (52) and Ubiquilin 2 Kits (7) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
UBQLN2 29978 Q9UHD9
Mouse UBQLN2 UBQLN2 54609 Q9QZM0
Rat UBQLN2 UBQLN2 317396  
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Top Ubiquilin 2 Proteins at antibodies-online.com

Showing 2 out of 3 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
HOST_Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
HOST_Wheat germ Human GST tag 10 μg Log in to see 9 Days
$405.71
Details

UBQLN2 Proteins by Origin and Source

Origin Expressed in Conjugate
Human ,
,

More Proteins for Ubiquilin 2 (UBQLN2) Interaction Partners

Human Ubiquilin 2 (UBQLN2) interaction partners

  1. UBQLN2 is specifically expressed in the urine of urothelial carcinoma patients.

  2. Results showed that UBQLN2 is selectively recruited to nuclear inclusions in Huntington's disease but not spinocerebellar ataxia (show USP14 Proteins) type 3

  3. These findings provide a molecular basis for the development of ALS/FTD-associated proteinopathy and establish novel therapeutic targets for ALS.

  4. Mutations in UBQLN2 gene cause dominant inheritance of amyotrophic lateral sclerosis due to Defective Proteasome Delivery.

  5. UBQLN2 may be a new molecular target for chemotherapeutics and a useful clinicopathological marker in human osteosarcoma.

  6. ALS (show IGFALS Proteins)-linked mutations in ubiquilin-2 or hnRNPA1 (show HNRNPA1 Proteins) reduce interaction between ubiquilin-2 and hnRNPA1 (show HNRNPA1 Proteins)

  7. ALS (show IGFALS Proteins)-linked mutations in both OPTN (show OPTN Proteins) and UBQLN2 interfere with the constitution of specific endosomal vesicles, suggesting that the vesicles are involved in protein homeostasis and that these proteins function in common pathological processes.

  8. A single putative mutation of UBQLN2 in a cohort of patients with front temporal lobar degeneration was found.

  9. Data indicate cognitive deficits in mutant ubiquilin 2 protein UBQLN2P497H transgenic mice.

  10. Causative mutation in the UBQLN2 gene is rare in Korean patients with either familial or sporadic ALS.

Mouse (Murine) Ubiquilin 2 (UBQLN2) interaction partners

  1. Results showed that UBQLN2 is selectively recruited to nuclear inclusions in Huntington's disease but not spinocerebellar ataxia (show USP14 Proteins) type 3

  2. UBQLN2 dysregulation in neurons can drive NF-kappaB (show NFKB1 Proteins) activation and cytosolic TDP-43 (show TARDBP Proteins) aggregation.

  3. Transduction of UBQLN2 mutants (P497H, P497S, and P506T) induce proteinopathy and cause behavioral deficits, supporting a "toxic" gain-of-function amyotrophic lateral sclerosis model, in mice.

  4. results were confirmed by similar findings for ubiquilin-1 (show UBQLN1 Proteins) and -2 in human brain tissue sections, where accumulation was observed in huntingtin (show HTT Proteins) inclusions

  5. UBQLN2-transfected cells did not show increased starvation-induced cell death.

Ubiquilin 2 (UBQLN2) Protein Profile

Protein Summary

This gene encodes an ubiquitin-like protein (ubiquilin) that shares high degree of similarity with related products in yeast, rat and frog. Ubiquilins contain a N-terminal ubiquitin-like domain and a C-terminal ubiquitin-associated domain. They physically associate with both proteasomes and ubiquitin ligases\; and thus, are thought to functionally link the ubiquitination machinery to the proteasome to affect in vivo protein degradation. This ubiquilin has also been shown to bind the ATPase domain of the Hsp70-like Stch protein.

Gene names and symbols associated with Ubiquilin 2 Proteins (UBQLN2)

  • ubiquilin 1 (ubqln1)
  • ubiquilin 2 (UBQLN2)
  • ubiquilin 2 (LOC100347089)
  • ubiquilin 2 (Ubqln2)
  • ALS15 protein
  • Chap1 protein
  • da41 protein
  • Dsk2 protein
  • HRIHFB2157 protein
  • N4BP4 protein
  • plic-1 protein
  • Plic-2 protein
  • Plic2 protein
  • RGD1563566 protein
  • UBQLN2 protein
  • ubqn protein
  • xdrp1 protein

Protein level used designations for Ubiquilin 2 Proteins (UBQLN2)

ubiquilin 2 , ubiquilin-2 , Nedd4 binding protein 4 , protein linking IAP with cytoskeleton 2 , ubiquitin-like product Chap1/Dsk2 , Ubiquitin-related protein

GENE ID SPECIES
394829 Xenopus (Silurana) tropicalis
419078 Gallus gallus
446997 Xenopus laevis
491909 Canis lupus familiaris
539529 Bos taurus
743819 Pan troglodytes
100347089 Oryctolagus cuniculus
29978 Homo sapiens
54609 Mus musculus
317396 Rattus norvegicus
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