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anti-Ubiquitin Conjugation Factor E4 B (UBE4B) Antibodies

The modification of proteins with ubiquitin is an important cellular mechanism for targeting abnormal or short-lived proteins for degradation. Additionally we are shipping UBE4B Proteins (3) and many more products for this protein.

list all antibodies Gene Name GeneID UniProt
UBE4B 298652  
UBE4B 10277 O95155
UBE4B 63958 Q9ES00
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Top anti-UBE4B Antibodies at antibodies-online.com

Showing 10 out of 45 products:

Catalog No. Reactivity Host Conjugate Application Images Quantity Supplier Delivery Price Details
Human Rabbit Un-conjugated WB WB Suggested Anti-UBE4B Antibody Titration: 0.2-1 ug/mlPositive Control: Human brain 100 μL Log in to see 2 to 3 Days
$289.00
Details
Human Rabbit Un-conjugated EIA, IHC (p), WB 0.4 mL Log in to see 6 to 8 Days
$390.50
Details
Human Rabbit Un-conjugated IHC (p), WB The anti-UBE4B Pab (ABIN388841) is used in Western blot to detect UBE4B in mouse kidney tissue lysate. Formalin-fixed and paraffin-embedded human cancer tissue reacted with the primary antibody, which was peroxidase-conjugated to the secondary antibody, followed by AEC staining. BC = breast carcinoma. HC = hepatocarcinoma 400 μL Log in to see 10 to 11 Days
$324.50
Details
Human Rabbit Un-conjugated ICC, IF, IHC (p), WB WB Image Sample (30 ug of whole cell lysate) A: Hep G2 , 5% SDS PAGE antibody diluted at 1:10000 IHC-P Image Immunohistochemical analysis of paraffin-embedded CA922 xenograft, using UBE4B, antibody at 1:500 dilution. 100 μL Log in to see 2 to 3 Days
$358.60
Details
Human Rabbit Un-conjugated WB 50 μg Log in to see 8 to 10 Days
$551.83
Details
Human Rabbit Un-conjugated IP, WB Western Blot and Immunoprecipitation: UBE4B Antibody [ABIN188793] - Detection of Human and Mouse UBE4B by Western Blot (h&m) and Immunoprecipitation (h). Samples: Whole cell lysate from HeLa (5, 15 and 50 mcg for WB, 1 mg for IP, 20% of IP loaded), 293T (T, 50 mcg) and mouse NIH3T3 (M, 50 mcg) cells. Antibodies: Affinity purified rabbit anti-UBE4B antibody ABIN188793 used for WB at 0.04 mcg/ml (A) and 0.1 mcg/ml (B) and used for IP at 3 mcg/mg lysate. UBE4B was also immunoprecipitated by rabbit anti-UBE4B antibody ABIN188794, which recognizes a downstream epitope. Detection: Chemiluminescence with exposure times of 30 seconds (A) and 3 minutes (B). 0.1 mL Log in to see 5 to 7 Days
$486.94
Details
Human Rabbit Biotin IHC, ELISA, WB   200 μL Log in to see 8 to 10 Days
$969.83
Details
Human Mouse Un-conjugated ELISA, WB UBE4B monoclonal antibody (M01), clone 8F9 Western Blot analysis of UBE4B expression in Hela S3 NE . Western Blot detection against Immunogen (36.63 KDa) . 100 μg Log in to see 9 Days
$430.00
Details
Human Rabbit Un-conjugated IHC, IHC (p), WB   0.1 mL Log in to see 8 to 11 Days
$439.69
Details
Human Rabbit Un-conjugated IHC, WB 400 μL Log in to see 6 Days
$457.14
Details

UBE4B Antibodies by Reactivity, Application, Clonality and Conjugate

Attributes Applications Host Clonality Conjugate
Rat (Rattus)


Human , ,
,
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Mouse (Murine)


Top referenced anti-UBE4B Antibodies

  1. Human Polyclonal UBE4B Primary Antibody for EIA, IHC (p) - ABIN357483 : Ishikawa, Nagase, Suyama, Miyajima, Tanaka, Kotani, Nomura, Ohara: Prediction of the coding sequences of unidentified human genes. X. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro. in DNA research : an international journal for rapid publication of reports on genes and genomes 1998 (PubMed)
    Show all 2 references for ABIN357483

  2. Human Polyclonal UBE4B Primary Antibody for IHC (p), WB - ABIN388841 : Mahoney, Odin, White, Shaffer, Koff, Casciola-Rosen, Rosen: The human homologue of the yeast polyubiquitination factor Ufd2p is cleaved by caspase 6 and granzyme B during apoptosis. in The Biochemical journal 2002 (PubMed)
    Show all 2 references for ABIN388841

  3. Human Polyclonal UBE4B Primary Antibody for IHC, IHC (p) - ABIN4363967 : Arabi, Ullah, Branca, Johansson, Bandarra, Haneklaus, Fu, Ariës, Nilsson, Den Boer, Pokrovskaja, Grandér, Xiao, Rocha, Lehtiö, Sangfelt: Proteomic screen reveals Fbw7 as a modulator of the NF-κB pathway. in Nature communications 2012 (PubMed)

  4. Human Polyclonal UBE4B Primary Antibody for WB - ABIN2785770 : Olsen, Blagoev, Gnad, Macek, Kumar, Mortensen, Mann: Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. in Cell 2006 (PubMed)

More Antibodies against UBE4B Interaction Partners

Human Ubiquitin Conjugation Factor E4 B (UBE4B) interaction partners

  1. UBE4B promotes endogenous phospho-p53 (show TP53 Antibodies)(S15 (show FBLN3 Antibodies)) and phospho-p53 (show TP53 Antibodies)(S392) degradation in response to gamma irradiation. UBE4B plays an important role in regulating phosphorylated p53 (show TP53 Antibodies) following DNA damage.

  2. UBE4B overexpression promotes the oncogenic properties of HCC (show FAM126A Antibodies) and is correlated with an unfavorable prognosis in HCC (show FAM126A Antibodies) patients.

  3. UBE4B regulates p53 (show TP53 Antibodies) in breast cancer

  4. We propose a model in which the coordinated action of UBE4B, ESCRT-0, and the deubiquitinating enzyme USP8 (show USP8 Antibodies) enable the endosomal sorting and lysosomal degradation of the EGFR (show EGFR Antibodies).

  5. UBE4B-mediated growth factor receptor (show RYK Antibodies) trafficking may contribute to the poor prognosis of patients who have neuroblastoma (show ARHGEF16 Antibodies) tumors with 1p36 deletions.

  6. The regulated expression of these UFD2a isoforms most likely imparts divergent functions that are important for myogenesis.

  7. we found somatic mutations of HERC2 (show HERC2 Antibodies), HERC3 (show HERC3 Antibodies), TRIP12 (show TRIP12 Antibodies), UBE2Q1 (show UBE2Q1 Antibodies) and UBE4B genes in gastric carcinoma and colorectal carcinomas with microsatellite instability

  8. data indicate that amplification and overexpression of UBE4B represent previously undescribed molecular mechanisms of inactivation of p53 (show TP53 Antibodies) in brain tumors

  9. determined structures of E4B U box free and bound to UbcH5c (show UBE2D3 Antibodies) and Ubc4 (show UBE2D2 Antibodies) E2s; findings show E4B U box is a monomer stabilized by a network of hydrogen bonds; findings suggest allosteric regulation of UbcH5c (show UBE2D3 Antibodies) and Ubc4 (show UBE2D2 Antibodies) by E4B U box

  10. A splice site mutation was found in UBE4b. UBE4B expression was diminished in the high-stage/poor-outcome tumors.UBE4B stands out as the strongest candidate NBL (show NUMBL Antibodies) tumor suppressor gene in the region at this stage.

Mouse (Murine) Ubiquitin Conjugation Factor E4 B (UBE4B) interaction partners

  1. The regulated expression of these UFD2a isoforms most likely imparts divergent functions that are important for myogenesis.

  2. Characterization of the UFD2a gene.

  3. UFD2a is essential for the development of cardiac muscle, as well as for the protection of spinocerebellar neurons from degeneration induced by endoplasmic reticulum stress.

UBE4B Antigen Profile

Protein Summary

The modification of proteins with ubiquitin is an important cellular mechanism for targeting abnormal or short-lived proteins for degradation. Ubiquitination involves at least three classes of enzymes: ubiquitin-activating enzymes, or E1s, ubiquitin-conjugating enzymes, or E2s, and ubiquitin-protein ligases, or E3s. This gene encodes an additional conjugation factor, E4, which is involved in multiubiquitin chain assembly. This gene is also the strongest candidate in the neuroblastoma tumor suppressor genes. Alternatively spliced transcript variants encoding distinct isoforms have been found for this gene.

Gene names and symbols associated with UBE4B

  • ubiquitination factor E4B (Ube4b) antibody
  • ubiquitin conjugation factor E4 B (LinJ30.1380) antibody
  • ubiquitin conjugation factor E4 B (LbrM30_V2.1130) antibody
  • ubiquitin conjugation factor E4 B (Tsp_12732) antibody
  • ubiquitin conjugation factor E4 B (Tsp_01624) antibody
  • ubiquitination factor E4B, UFD2 homolog (S. cerevisiae) (ube4b) antibody
  • ubiquitination factor E4B (UBE4B) antibody
  • ubiquitination factor E4B, UFD2 homolog (S. cerevisiae) (Ube4b) antibody
  • 4930551I19Rik antibody
  • 4933406G05Rik antibody
  • AU014668 antibody
  • D4Bwg0973e antibody
  • E4 antibody
  • HDNB1 antibody
  • mKIAA0684 antibody
  • UBOX3 antibody
  • UFD2 antibody
  • UFD2a antibody
  • Ufd2p antibody

Protein level used designations for UBE4B

ubiquitin conjugation factor E4 B , ubiquitination factor E4B (UFD2 homolog, yeast) , ubiquitination factor E4B, UFD2 homolog , ubiquitin fusion degradation protein 2 , UFD2A-III/UBE4B-III splice isoform , homologous to yeast UFD2 , homozygously deleted in neuroblastoma 1 , homozygously deleted in neuroblastoma-1 , ubiquitin-fusion degradation protein 2 , ubiquitination factor E4B (homologous to yeast UFD2)

GENE ID SPECIES
298652 Rattus norvegicus
5070994 Leishmania infantum JPCM5
5417638 Leishmania braziliensis MHOM/BR/75/M2904
10899986 Trichinella spiralis
10911805 Trichinella spiralis
100380420 Salmo salar
10277 Homo sapiens
63958 Mus musculus
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