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UBE4B antibody (Ubiquitin Conjugation Factor E4 B) (AA 112-142)

Details for Product anti-UBE4B Antibody No. ABIN388841, Supplier: Log in to see
Antigen
  • 4930551I19Rik
  • 4933406G05Rik
  • AU014668
  • D4Bwg0973e
  • E4
  • HDNB1
  • mKIAA0684
  • UBOX3
  • UFD2
  • UFD2a
  • ufd2a
  • UFD2A
  • Ufd2p
Epitope
AA 112-142, N-Term
19
4
3
3
3
2
1
1
1
Reactivity
Human, Mouse (Murine)
44
8
5
Host
Rabbit
39
5
Clonality (Clone)
Polyclonal ()
Conjugate
This UBE4B antibody is un-conjugated
2
2
2
2
2
2
Application
Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Western Blotting (WB)
40
21
20
8
7
5
4
1
1
1
1
Supplier
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Immunogen This UBE4B antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 112-142 AA from the N-terminal region of human UBE4B.
Clone RB4133
Isotype Ig
Specificity This UBE4B antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 120~149 amino acids from the N-terminal region of human UBE4B.
Purification This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.
Alternative Name UBE4B (UBE4B Antibody Abstract)
Background The modification of proteins with ubiquitin is an important cellular mechanism for targeting abnormal or short-lived proteins for degradation. Ubiquitination involves at least three classes of enzymes: ubiquitin-activating enzymes, or E1s, ubiquitin-conjugating enzymes, or E2s, and ubiquitin-protein ligases, or E3s. UBE4B represents an additional conjugation factor, E4, which is involved in multiubiquitin chain assembly. UBE4B also the strongest candidate among the neuroblastoma tumor suppressors.
Synonyms: Ubiquitin conjugation factor E4 B, Ubiquitin-fusion degradation protein 2, Homozygously deleted in neuroblastoma-1, HDNB1, KIAA0684, UFD2
Molecular Weight 133275 DA
Gene ID 10277
UniProt O95155
Research Area Ubiquitin-related antibodies, Apoptosis/Necrosis, Protein Modifications, Cancer, Neurology, Cell Structure
Application Notes WB = 1:1000, IHC (p) = 1:50-100
Restrictions For Research Use only
Format Liquid
Concentration 2 mg/mL
Buffer PBS with 0.09 % (W/V) sodium azide
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage 4 °C/-20 °C
Storage Comment Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C in small aliquots to prevent freeze-thaw cycles.
Expiry Date 6 months
Supplier Images
Western Blotting (WB) image for anti-UBE4B antibody (Ubiquitin Conjugation Factor E4 B) (AA 112-142) (ABIN388841) The anti-UBE4B Pab (ABIN388841) is used in Western blot to detect UBE4B in mouse kidn...
Immunohistochemistry (IHC) image for anti-UBE4B antibody (Ubiquitin Conjugation Factor E4 B) (AA 112-142) (ABIN388841) Formalin-fixed and paraffin-embedded human cancer tissue reacted with the primary ant...
Background publications Mahoney, Odin, White, Shaffer, Koff, Casciola-Rosen, Rosen: "The human homologue of the yeast polyubiquitination factor Ufd2p is cleaved by caspase 6 and granzyme B during apoptosis." in: The Biochemical journal, Vol. 361, Issue Pt 3, pp. 587-95, 2002 (PubMed).

Ishikawa, Nagase, Suyama, Miyajima, Tanaka, Kotani, Nomura, Ohara: "Prediction of the coding sequences of unidentified human genes. X. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro." in: DNA research : an international journal for rapid publication of reports on genes and genomes, Vol. 5, Issue 3, pp. 169-76, 1998 (PubMed).