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anti-Ubiquitin Protein Ligase E3 Component N-Recognin 5 (UBR5) Antibodies

UBR5 encodes a progestin-induced protein, which belongs to the HECT (homology to E6-AP carboxyl terminus) family. Additionally we are shipping UBR5 Kits (3) and and many more products for this protein.

list all antibodies Gene Name GeneID UniProt
UBR5 51366 O95071
UBR5 70790 Q80TP3
UBR5 117060  
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Top anti-UBR5 Antibodies at antibodies-online.com

Showing 10 out of 79 products:

Catalog No. Reactivity Host Conjugate Application Images Quantity Supplier Delivery Price Details
Human Goat Un-conjugated IHC, ELISA, WB   100 μg Log in to see 4 to 5 Days
$318.20
Details
Cow Goat Un-conjugated EIA, IHC (p), IP, WB EDD1 / HYD  Antibody  staining of paraffin embedded Human Testis at 4 µg/ml. Steamed antigen retrieval with Tris/EDTA buffer pH 9, HRP-staining. These results could not be obtained after antigen retrieval at pH 6. 0.1 mg Log in to see 6 to 8 Days
$379.50
Details
Human Rabbit Un-conjugated ICC, IF, IHC, IHC (p), IP, WB Detection of EDD1 by Western Blot and Immunoprecipitation. Samples: A. Whole lysate from HeLa (5, 15 and 50 mcg) and mouse NIH3T3 (M, 50 mcg) cells. B. Whole cell lysate (1 mg/IP, 1/4 of IP loaded) from HeLa cells. Antibodies: Affinity purified rabbit anti-EDD1 antibody ABIN151138 used at 0.1 mcg/ml for WB (A) and 3 mcg/ml for IP (B). Detection: Chemiluminescence with an exposure time of 30 seconds (A and B). 100 μL Log in to see 5 to 7 Days
$477.75
Details
Human Rabbit Un-conjugated IHC (p), WB 0.1 mg Log in to see 6 to 8 Days
$390.50
Details
Human Rabbit Un-conjugated IHC, ELISA, WB Western blot analysis of extracts from A549 cells, using EDD Antibody. The lane on the right is treated with the synthesized peptide. Immunohistochemistry analysis of paraffin-embedded human breast carcinoma tissue, using EDD Antibody. The picture on the right is treated with the synthesized peptide. 100 μg Log in to see 2 to 3 Days
$302.50
Details
Human Goat Un-conjugated IHC (p), ELISA Human Spleen: Formalin-Fixed, Paraffin-Embedded (FFPE) 50 μg Log in to see 8 to 10 Days
$451.00
Details
Human Rabbit Un-conjugated IHC (p), ELISA, WB Anti-UBR5 antibody IHC staining of human brain, cortex. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody  ABIN1104914 concentration 10 ug/ml. 50 μL Log in to see 8 to 10 Days
$451.00
Details
Cow Rabbit Un-conjugated IHC, WB Immunohistochemical analysis of UBR5 staining in human breast cancer formalin fixed paraffin embedded tissue section. The section was pre-treated using heat mediated antigen retrieval with sodium citrate buffer (pH 6.0). The section was then incubated with the antibody at room temperature and detected using an HRP conjugated compact polymer system. DAB was used as the chromogen. The section was then counterstained with haematoxylin and mounted with DPX. Western blot analysis of UBR5 expression in Jurkat (A), HeLa (B), MDAMB468 (C), NIH3T3 (D) whole cell lysates. 200 μL Log in to see 9 Days
$487.50
Details
Cow Goat Un-conjugated EIA, IHC (p) Human Spleen: Formalin-Fixed, Paraffin-Embedded (FFPE) 50 μg Log in to see 6 to 8 Days
$500.50
Details
Human Rabbit Un-conjugated IHC (p), IP, WB Human Brain: Formalin-Fixed, Paraffin-Embedded (FFPE) 50 μg Log in to see 8 to 10 Days
$595.83
Details

UBR5 Antibodies by Reactivity, Application, Clonality and Conjugate

Attributes Applications Host Clonality Conjugate
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Top referenced anti-UBR5 Antibodies

  1. Human Polyclonal UBR5 Primary Antibody for IHC, ELISA - ABIN184976 : Henderson, Russell, Hird, Muñoz, Clancy, Lehrbach, Calanni, Jans, Sutherland, Watts: EDD, the human hyperplastic discs protein, has a role in progesterone receptor coactivation and potential involvement in DNA damage response. in The Journal of biological chemistry 2002 (PubMed)

  2. Cow (Bovine) Polyclonal UBR5 Primary Antibody for EIA, IHC (p) - ABIN1109445 : Hay-Koren, Caspi, Zilberberg, Rosin-Arbesfeld: The EDD E3 ubiquitin ligase ubiquitinates and up-regulates beta-catenin. in Molecular biology of the cell 2011 (PubMed)

More Antibodies against UBR5 Interaction Partners

Human Ubiquitin Protein Ligase E3 Component N-Recognin 5 (UBR5) interaction partners

  1. Study highlights many functional biological role of UBR5 especially in cancer where it seems to be a key regulator of cell signaling. [review]

  2. Colony-formation assays and soft agar assays show that gain of function of TIP60 or depletion of EDD1 in HPV-positive cervical cancer cells significantly inhibits cell growth in vitro

  3. Human herpesvirus-6 U14 induces cell cycle arrest in G2/M phase by associating with a cellular protein, EDD.

  4. Elevated metaphase RanGTP levels use Ubr5 to couple overall chromosome congression to SAC (show ADCY10 Antibodies) silencing.

  5. results confirm the role of the MLLE domain of UBR5 in substrate recruitment and suggest a potential role in regulating UBR5 ligase activity.

  6. these observations highlight the potential role of EDD in regulating mitotic progression and the cellular response to perturbed mitosis.

  7. Utilizing a high throughput RNAi screening approach author identified UBR5, a protein commonly amplified in breast cancer, as a novel regulator of ERalpha (show ESR1 Antibodies) protein levels and transcriptional activity.

  8. the alpha4 N-terminus binding to endogenous PP2Ac (show PPP2CA Antibodies) and PABP (show PABPC1 Antibodies), and the C-terminus to EDD, is reported.

  9. These results identify EDD as a dual regulator of cell survival and cisplatin resistance and suggest that EDD is a therapeutic target for ovarian cancer.

  10. Determined is the three-dimensional solution structure of the catalytic RING2 (show RNF2 Antibodies) domain from HHARI (show ARIH1 Antibodies). It shows glimpses of a HECT E3 ligase.

Mouse (Murine) Ubiquitin Protein Ligase E3 Component N-Recognin 5 (UBR5) interaction partners

  1. UBR5-mediated ATMIN (show ATMIN Antibodies) ubiquitination is a vital event for ATM (show ATM Antibodies) pathway selection and activation in response to DNA damage

  2. a novel function of RIP1 (show RALBP1 Antibodies) kinase involving its interaction with EDD to regulate JNK (show MAPK8 Antibodies) activation and TNFalpha (show TNF Antibodies) production.

  3. Silencing Edd1 with shRNA in mouse embryonic stem cells significantly suppressed their growth.

  4. The SCF (show KITLG Antibodies) E3 ligase complex containing Fbxo40 (show FBXO40 Antibodies) directly ubiquitinates IRS1 (show IRS1 Antibodies), and this activity is enhanced by increased tyrosine phosphorylation of IRS1 (show IRS1 Antibodies).

  5. Through the PABC domain, EDD participates in miRNA silencing by recruiting downstream effectors.

  6. UBR5 can attenuate myocardin (show MYOCD Antibodies) protein degradation resulting in increased myocardin (show MYOCD Antibodies) protein expression without affecting myocardin (show MYOCD Antibodies) mRNA expression.

  7. Results suggest that Edd has an essential role in extraembryonic development.

UBR5 Antigen Profile

Protein Summary

This gene encodes a progestin-induced protein, which belongs to the HECT (homology to E6-AP carboxyl terminus) family. The HECT family proteins function as E3 ubiquitin-protein ligases, targeting specific proteins for ubiquitin-mediated proteolysis. This gene is localized to chromosome 8q22 which is disrupted in a variety of cancers. This gene potentially has a role in regulation of cell proliferation or differentiation.

Gene names and symbols associated with UBR5

  • ubiquitin protein ligase E3 component n-recognin 5 (UBR5) antibody
  • ubiquitin protein ligase E3 component n-recognin 5 (Ubr5) antibody
  • 4432411E13Rik antibody
  • AW549941 antibody
  • C77315 antibody
  • D030042K14 antibody
  • Dd5 antibody
  • Edd antibody
  • Edd1 antibody
  • HYD antibody
  • mKIAA0896 antibody
  • Rat100 antibody

Protein level used designations for UBR5

E3 identified by differential display , E3 ubiquitin protein ligase, HECT domain containing, 1 , E3 ubiquitin-protein ligase UBR5 , E3 ubiquitin-protein ligase, HECT domain-containing 1 , hHYD , hyperplastic discs protein homolog , progestin induced protein , progestin-induced protein , ubiquitin-protein ligase , extraembryonic development

GENE ID SPECIES
51366 Homo sapiens
70790 Mus musculus
117060 Rattus norvegicus
420252 Gallus gallus
475055 Canis lupus familiaris
100157625 Sus scrofa
Selected quality suppliers for anti-UBR5 (UBR5) Antibodies
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