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anti-Ubiquitin Protein Ligase E3A (ube3a) Antibodies

ube3a encodes an E3 ubiquitin-protein ligase, part of the ubiquitin protein degradation system. Additionally we are shipping ube3a Kits (12) and ube3a Proteins (8) and many more products for this protein.

list all antibodies Gene Name GeneID UniProt
ube3a 7337 Q05086
ube3a 22215  
ube3a 361585  
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Top anti-ube3a Antibodies at antibodies-online.com

Showing 10 out of 80 products:

Catalog No. Reactivity Host Conjugate Application Images Quantity Supplier Delivery Price Details
Cow Rabbit Un-conjugated WB WB Suggested Anti-UBE3A Antibody Titration: 0.2-1 ug/mlELISA Titer: 1:312500Positive Control: Hela cell lysate WB Suggested Anti-UBE3A  Antibody Titration: 0.2-1 µg/mL ELISA Titer: 1:.12500  Positive Control: Hela cell lysate  UBE3A is strongly supported by BioGPS gene expression data to be expressed in Human HeLa cells 100 μL Log in to see 2 to 3 Days
$289.00
Details
Cow Rabbit Un-conjugated WB WB Suggested Anti-UBE3A Antibody Titration: 0.2-1 ug/mlELISA Titer: 1:312500Positive Control: Hela cell lysate WB Suggested Anti-UBE3A  Antibody Titration: 0.2-1 µg/mL ELISA Titer: 1:.12500  Positive Control: Hela cell lysate  UBE3A is strongly supported by BioGPS gene expression data to be expressed in Human HeLa cells 100 μL Log in to see 2 to 3 Days
$289.00
Details
Human Rabbit Un-conjugated EIA, IHC (p), WB 0.4 mL Log in to see 6 to 8 Days
$390.50
Details
Human Rabbit Un-conjugated FACS, IF, IHC (p), WB Western blot analysis of UBE3A Antibody (C-term) (ABIN388925) in T47D cell line lysates (35 µg/lane).UBE3A(arrow) was detected using the purified polyclonal antibody. Formalin-fixed and paraffin-embedded human cancer tissue reacted with the primary antibody, which was peroxidase-conjugated to the secondary antibody, followed by AEC staining. BC = breast carcinoma. HC = hepatocarcinoma 400 μL Log in to see 10 to 11 Days
$324.50
Details
Human Mouse Un-conjugated IF, WB Western blot analysis of UBE3A on a EB-1 cell lysate (Human B lymphoblast, Burkitt's lymphoma, ATCC HTB-60). Lane 1: 1:500, lane 2: 1:1000, lane 3: 1:2000 dilution of the mouse anti- UEB3A antibody. 50 μg Log in to see 5 to 6 Days
$205.42
Details
Human Mouse Un-conjugated IF, WB Immunofluorescence of monoclonal antibody to UBE3A on HeLa cell (antibody concentration 10 µg/mL). UBE3A monoclonal antibody (M01), clone 2F6 Western Blot analysis of UBE3A expression in Jurkat. 0.1 mg Log in to see 8 to 11 Days
$450.00
Details
Human Mouse Un-conjugated IF, IHC (p), ELISA, WB Immunoperoxidase of monoclonal antibody to UBE3A on formalin-fixed paraffin-embedded human lung. [antibody concentration 3 ug/ml] Immunofluorescence of monoclonal antibody to UBE3A on HeLa cell. [antibody concentration 10 ug/ml] 100 μg Log in to see 9 Days
$430.00
Details
Human Mouse Un-conjugated IF, IHC (p), WB 0.1 mg Log in to see 3 to 4 Days
$601.76
Details
Human Rabbit Un-conjugated IHC (p) IHC-P Image UBE3A antibody detects UBE3A protein at cytosol on mouse middle brain by immunohistochemical analysis. Sample: Paraffin-embedded mouse middle brain. UBE3A antibody , dilution: 1:500. IHC-P Image UBE3A antibody detects UBE3A protein at nucleus on human ovarian carcinoma by immunohistochemical analysis. Sample: Paraffin-embedded human ovarian carcinoma. UBE3A antibody , dilution: 1:500. 100 μL Log in to see 2 to 3 Days
$358.60
Details
Human Rabbit Un-conjugated WB 50 μg Log in to see 8 to 10 Days
$551.83
Details

ube3a Antibodies by Reactivity, Application, Clonality and Conjugate

Attributes Applications Host Clonality Conjugate
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Top referenced anti-ube3a Antibodies

  1. Human Polyclonal ube3a Primary Antibody for EIA, IHC (p) - ABIN357571 : Be, Hong, Wei, Androphy, Chen, Baleja: Solution structure determination and mutational analysis of the papillomavirus E6 interacting peptide of E6AP. in Biochemistry 2001 (PubMed)
    Show all 5 references for ABIN357571

  2. Human Monoclonal ube3a Primary Antibody for IF, WB - ABIN393616 : Zaaroor-Regev, de Bie, Scheffner, Noy, Shemer, Heled, Stein, Pikarsky, Ciechanover: Regulation of the polycomb protein Ring1B by self-ubiquitination or by E6-AP may have implications to the pathogenesis of Angelman syndrome. in Proceedings of the National Academy of Sciences of the United States of America 2010 (PubMed)
    Show all 5 references for ABIN393616

  3. Human Polyclonal ube3a Primary Antibody for FACS, IF - ABIN388925 : Kleijnen, Shih, Zhou, Kumar, Soccio, Kedersha, Gill, Howley: The hPLIC proteins may provide a link between the ubiquitination machinery and the proteasome. in Molecular cell 2000 (PubMed)
    Show all 5 references for ABIN388925

  4. Human Monoclonal ube3a Primary Antibody for IF, WB - ABIN968525 : Matsuura, Sutcliffe, Fang, Galjaard, Jiang, Benton, Rommens, Beaudet: De novo truncating mutations in E6-AP ubiquitin-protein ligase gene (UBE3A) in Angelman syndrome. in Nature genetics 1997 (PubMed)
    Show all 2 references for ABIN968525

  5. Human Monoclonal ube3a Primary Antibody for IF, IHC (p) - ABIN2477024 : Wolyniec, Shortt, de Stanchina, Levav-Cohen, Alsheich-Bartok, Louria-Hayon, Corneille, Kumar, Woods, Opat, Johnstone, Scott, Segal, Pandolfi, Fox, Strasser, Jiang, Lowe, Haupt, Haupt: E6AP ubiquitin ligase regulates PML-induced senescence in Myc-driven lymphomagenesis. in Blood 2012 (PubMed)

  6. Cow (Bovine) Polyclonal ube3a Primary Antibody for WB - ABIN2775647 : Bedard, Underbrink, Howie, Galloway: The E6 oncoproteins from human betapapillomaviruses differentially activate telomerase through an E6AP-dependent mechanism and prolong the lifespan of primary keratinocytes. in Journal of virology 2008 (PubMed)

  7. Human Monoclonal ube3a Primary Antibody for IF, IHC (p) - ABIN563326 : Underbrink, Howie, Bedard, Koop, Galloway: E6 proteins from multiple human betapapillomavirus types degrade Bak and protect keratinocytes from apoptosis after UVB irradiation. in Journal of virology 2008 (PubMed)

More Antibodies against ube3a Interaction Partners

Fruit Fly (Drosophila melanogaster) Ubiquitin Protein Ligase E3A (ube3a) interaction partners

  1. Data indicate that E3 ligase called ube3 (dube3a) is required for brain development as mutants have defective mushroom bodies.

  2. Rpn10 is targeted for degradation by Ube3a.

  3. In Drosophila melanogaster the human homologue ube3a regulates the actin cytoskeleton and neuronal homeostasis.

  4. MeCP2 (show MECP2 Antibodies) and E6AP play a role in the transcriptional control of common target gene expression.

  5. Ube3a regulates serotonin and dopamine synthesis in the fly brain by increasing GTP cyclohydrolase I (show GCH1 Antibodies) activity.

  6. dube3a null mutants appear normal externally, but display abnormal locomotive behavior and circadian rhythms, and defective long-term memory; overexpression in the nervous system caused locomotion defects, dependent on the ubiquitin ligase activity

  7. Overexpression of dUBE3A decreased dendritic branching.

Human Ubiquitin Protein Ligase E3A (ube3a) interaction partners

  1. The observation of Dup15q syndrome in individuals with maternally but not paternally inherited duplications of chromosome 15q11-q13, suggest that UBE3A drives the Angelman syndrome phenotype in this disorder. (Review)

  2. our results indicate that CSN6 (show COPS6 Antibodies) is a positive regulator of E6AP and is important for cervical cancer development.

  3. Stable over-expression of E6-AP increases the proliferation and invasion of prostate tumor cells.

  4. Impairments in both synaptic plasticity and fear conditioning memory in UBE3A-deficient mice are significantly ameliorated by blocking SK2 (show KCNN2 Antibodies). These results elucidate a mechanism by which UBE3A directly influences cognitive function.

  5. Study describes an upstream regulatory mechanism for UBE3A and provides a comprehensive understanding of how missense mutations linked to Angelman syndrome and autism affect UBE3A protein function.

  6. The miR (show MLXIP Antibodies)-375-UBE3A axis is important in modulating radiosensitivity of HR-HPV (+) cervical cancer.

  7. UBE3A dampens ERK (show EPHB2 Antibodies) pathway signalling in HPV E6 transformed HeLa cells

  8. crystal structure of a ternary complex comprising full-length human papilloma virus type 16 (HPV-16) E6, the LxxLL motif of E6AP and the core domain of p53 (show TP53 Antibodies)

  9. UBE3A may regulate the expression of annexin A2 (show ANXA2 Antibodies), resulting in promotion of proliferation and invasion and suppression of apoptosis in breast cancer cells.

  10. The activity of E6AP is controlled by noncovalent interactions with ubiquitin and allosteric activators such as the HPV E6 oncoprotein.

Mouse (Murine) Ubiquitin Protein Ligase E3A (ube3a) interaction partners

  1. Results substantiate GABAergic Ube3a loss as the principal cause of circuit hyperexcitability in Angelman syndrome mice, lending insight into ictogenic mechanisms in AS.

  2. Loss of Ube3a from tyrosine hydroxylase (show TH Antibodies)-expressing neurons impairs mesoaccumbal, non-canonical GABA co-release and enhances reward-seeking behaviour measured by optical self-stimulation.

  3. Results suggest that the phenotypes observed in Angelman syndrome mice may be modulated by factors independent of Ube3a genotype

  4. UBE3A dampens ERK (show EPHB2 Antibodies) pathway signalling in HPV E6 transformed HeLa cells

  5. The normal window of development in Angelman syndrome patients is supported by an incompletely silenced paternal allele in developing neurons, resulting in a relative preservation of Ube3a expression during this crucial epoch of early development.

  6. Inactivation of Ube3a expression elevates BMAL1 (show ARNTL Antibodies) levels in brain regions that control circadian behavior of AS-model mice, indicating an important role for Ube3a in modulating BMAL1 (show ARNTL Antibodies) turnover.

  7. This study demonstrated that abnormal sleep patterns arise from a deficit in accumulation of sleep drive, uncovering the Ube3a gene as a novel genetic regulator of sleep homeostasis

  8. The deficiency of Ube3a in Huntington's disease (HD) mice brain also caused significant increase in global aggregates load, and these aggregates were less ubiquitinated when compared with age-matched HD mice.

  9. There are distinct neurodevelopmental windows when Ube3a restoration rescues Angelman-syndrome-like phenotypes. Motor deficits are rescued in adolescence. Anxiety, repetitive behavior, and epilepsy are rescued in early development.

  10. Mature oligodendrocytes express Ube3a in the cortex and white matter tracts during development.

Pig (Porcine) Ubiquitin Protein Ligase E3A (ube3a) interaction partners

  1. In the skeletal muscle of neonate pigs, both NECD (show NDN Antibodies) and SNRPN (show SNRPN Antibodies) were maternally imprinted, while UBE3A was not imprinted.

ube3a Antigen Profile

Protein Summary

This gene encodes an E3 ubiquitin-protein ligase, part of the ubiquitin protein degradation system. This imprinted gene is maternally expressed in brain and biallelically expressed in other tissues. Maternally inherited deletion of this gene causes Angelman Syndrome, characterized by severe motor and intellectual retardation, ataxia, hypotonia, epilepsy, absence of speech, and characteristic facies. The protein also interacts with the E6 protein of human papillomavirus types 16 and 18, resulting in ubiquitination and proteolysis of tumor protein p53. Alternative splicing of this gene results in three transcript variants encoding three isoforms with different N-termini. Additional transcript variants have been described, but their full length nature has not been determined.

Gene names and symbols associated with ube3a

  • Ubiquitin protein ligase E3A (Ube3a) antibody
  • ubiquitin protein ligase E3A (UBE3A) antibody
  • ubiquitin-protein ligase E3A (ube3a) antibody
  • ubiquitin protein ligase E3A (ube3a) antibody
  • ubiquitin protein ligase E3A (human papilloma virus E6-associated protein, Angelman syndrome) (ube3a) antibody
  • ubiquitin protein ligase E3A (Eint_040430) antibody
  • ubiquitin protein ligase E3A (Ube3a) antibody
  • 4732496B02 antibody
  • 5830462N02Rik antibody
  • A130086L21Rik antibody
  • ANCR antibody
  • As antibody
  • CG6190 antibody
  • das antibody
  • DDBDRAFT_0188760 antibody
  • DDBDRAFT_0302447 antibody
  • DDB_0188760 antibody
  • DDB_0302447 antibody
  • DKFZp459N106 antibody
  • Dmel\\CG6190 antibody
  • dube3a antibody
  • E6-AP antibody
  • EPVE6AP antibody
  • Hpve6a antibody
  • im:7140733 antibody
  • MGC69536 antibody
  • mKIAA4216 antibody
  • ube3a antibody
  • UME3A antibody
  • zgc:92173 antibody

Protein level used designations for ube3a

ubiquitin protein ligase E3A , CG6190-PA , Ube3a-PA , drosophila angelman syndrome , angelman syndrome , ubiquitin protein ligase E3A (human papilloma virus E6-associated protein, Angelman syndrome) , ubiquitin-protein ligase E3A , ubiquitin-protein ligase E3A-like , CTCL tumor antigen se37-2 , E6AP ubiquitin-protein ligase , human papilloma virus E6-associated protein , human papillomavirus E6-associated protein , oncogenic protein-associated protein E6-AP , renal carcinoma antigen NY-REN-54 , E6-AP ubiquitin protein ligase , ubiquitin conjugating enzyme E3A

GENE ID SPECIES
39266 Drosophila melanogaster
453269 Pan troglodytes
479010 Canis lupus familiaris
8627519 Dictyostelium discoideum AX4
100173699 Pongo abelii
100194730 Salmo salar
407881 Xenopus (Silurana) tropicalis
9699096 Encephalitozoon intestinalis ATCC 50506
100050725 Equus caballus
100385816 Callithrix jacchus
100438681 Pongo abelii
7337 Homo sapiens
22215 Mus musculus
792398 Danio rerio
533136 Bos taurus
361585 Rattus norvegicus
100522589 Sus scrofa
418686 Gallus gallus
100342825 Oryctolagus cuniculus
100730511 Cavia porcellus
380385 Xenopus laevis
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