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ube3a encodes an E3 ubiquitin-protein ligase, part of the ubiquitin protein degradation system. Additionally we are shipping ube3a Kits (12) and ube3a Proteins (8) and many more products for this protein.
Showing 10 out of 73 products:
Human Polyclonal ube3a Primary Antibody for EIA, IHC (p) - ABIN357571
Be, Hong, Wei, Androphy, Chen, Baleja: Solution structure determination and mutational analysis of the papillomavirus E6 interacting peptide of E6AP. in Biochemistry 2001
Show all 5 references for ABIN357571
Human Monoclonal ube3a Primary Antibody for IF, WB - ABIN393616
Zaaroor-Regev, de Bie, Scheffner, Noy, Shemer, Heled, Stein, Pikarsky, Ciechanover: Regulation of the polycomb protein Ring1B by self-ubiquitination or by E6-AP may have implications to the pathogenesis of Angelman syndrome. in Proceedings of the National Academy of Sciences of the United States of America 2010
Show all 5 references for ABIN393616
Human Polyclonal ube3a Primary Antibody for FACS, IF - ABIN388925
Kleijnen, Shih, Zhou, Kumar, Soccio, Kedersha, Gill, Howley: The hPLIC proteins may provide a link between the ubiquitination machinery and the proteasome. in Molecular cell 2000
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Human Monoclonal ube3a Primary Antibody for IF, WB - ABIN968525
Matsuura, Sutcliffe, Fang, Galjaard, Jiang, Benton, Rommens, Beaudet: De novo truncating mutations in E6-AP ubiquitin-protein ligase gene (UBE3A) in Angelman syndrome. in Nature genetics 1997
Show all 2 references for ABIN968525
Human Monoclonal ube3a Primary Antibody for IF, IHC (p) - ABIN2477024
Wolyniec, Shortt, de Stanchina, Levav-Cohen, Alsheich-Bartok, Louria-Hayon, Corneille, Kumar, Woods, Opat, Johnstone, Scott, Segal, Pandolfi, Fox, Strasser, Jiang, Lowe, Haupt, Haupt: E6AP ubiquitin ligase regulates PML-induced senescence in Myc-driven lymphomagenesis. in Blood 2012
Cow (Bovine) Polyclonal ube3a Primary Antibody for WB - ABIN2775647
Bedard, Underbrink, Howie, Galloway: The E6 oncoproteins from human betapapillomaviruses differentially activate telomerase through an E6AP-dependent mechanism and prolong the lifespan of primary keratinocytes. in Journal of virology 2008
Human Monoclonal ube3a Primary Antibody for IF, IHC (p) - ABIN563326
Underbrink, Howie, Bedard, Koop, Galloway: E6 proteins from multiple human betapapillomavirus types degrade Bak and protect keratinocytes from apoptosis after UVB irradiation. in Journal of virology 2008
Data indicate that E3 ligase called ube3 (dube3a) is required for brain development as mutants have defective mushroom bodies.
Rpn10 is targeted for degradation by Ube3a.
In Drosophila melanogaster the human homologue ube3a regulates the actin cytoskeleton and neuronal homeostasis.
MeCP2 (show MECP2 Antibodies) and E6AP play a role in the transcriptional control of common target gene expression.
Ube3a regulates serotonin and dopamine synthesis in the fly brain by increasing GTP cyclohydrolase I (show GCH1 Antibodies) activity.
dube3a null mutants appear normal externally, but display abnormal locomotive behavior and circadian rhythms, and defective long-term memory; overexpression in the nervous system caused locomotion defects, dependent on the ubiquitin ligase activity
Overexpression of dUBE3A decreased dendritic branching.
The observation of Dup15q syndrome in individuals with maternally but not paternally inherited duplications of chromosome 15q11-q13, suggest that UBE3A drives the Angelman syndrome phenotype in this disorder. (Review)
our results indicate that CSN6 (show COPS6 Antibodies) is a positive regulator of E6AP and is important for cervical cancer development.
Stable over-expression of E6-AP increases the proliferation and invasion of prostate tumor cells.
Impairments in both synaptic plasticity and fear conditioning memory in UBE3A-deficient mice are significantly ameliorated by blocking SK2 (show KCNN2 Antibodies). These results elucidate a mechanism by which UBE3A directly influences cognitive function.
Study describes an upstream regulatory mechanism for UBE3A and provides a comprehensive understanding of how missense mutations linked to Angelman syndrome and autism affect UBE3A protein function.
The miR (show MLXIP Antibodies)-375-UBE3A axis is important in modulating radiosensitivity of HR-HPV (+) cervical cancer.
UBE3A dampens ERK (show EPHB2 Antibodies) pathway signalling in HPV E6 transformed HeLa cells
crystal structure of a ternary complex comprising full-length human papilloma virus type 16 (HPV-16) E6, the LxxLL motif of E6AP and the core domain of p53 (show TP53 Antibodies)
UBE3A may regulate the expression of annexin A2 (show ANXA2 Antibodies), resulting in promotion of proliferation and invasion and suppression of apoptosis in breast cancer cells.
The activity of E6AP is controlled by noncovalent interactions with ubiquitin and allosteric activators such as the HPV E6 oncoprotein.
Results substantiate GABAergic Ube3a loss as the principal cause of circuit hyperexcitability in Angelman syndrome mice, lending insight into ictogenic mechanisms in AS.
Loss of Ube3a from tyrosine hydroxylase (show TH Antibodies)-expressing neurons impairs mesoaccumbal, non-canonical GABA co-release and enhances reward-seeking behaviour measured by optical self-stimulation.
Results suggest that the phenotypes observed in Angelman syndrome mice may be modulated by factors independent of Ube3a genotype
The normal window of development in Angelman syndrome patients is supported by an incompletely silenced paternal allele in developing neurons, resulting in a relative preservation of Ube3a expression during this crucial epoch of early development.
Inactivation of Ube3a expression elevates BMAL1 (show ARNTL Antibodies) levels in brain regions that control circadian behavior of AS-model mice, indicating an important role for Ube3a in modulating BMAL1 (show ARNTL Antibodies) turnover.
This study demonstrated that abnormal sleep patterns arise from a deficit in accumulation of sleep drive, uncovering the Ube3a gene as a novel genetic regulator of sleep homeostasis
The deficiency of Ube3a in Huntington's disease (HD) mice brain also caused significant increase in global aggregates load, and these aggregates were less ubiquitinated when compared with age-matched HD mice.
There are distinct neurodevelopmental windows when Ube3a restoration rescues Angelman-syndrome-like phenotypes. Motor deficits are rescued in adolescence. Anxiety, repetitive behavior, and epilepsy are rescued in early development.
Mature oligodendrocytes express Ube3a in the cortex and white matter tracts during development.
In the skeletal muscle of neonate pigs, both NECD (show NDN Antibodies) and SNRPN (show SNRPN Antibodies) were maternally imprinted, while UBE3A was not imprinted.
This gene encodes an E3 ubiquitin-protein ligase, part of the ubiquitin protein degradation system. This imprinted gene is maternally expressed in brain and biallelically expressed in other tissues. Maternally inherited deletion of this gene causes Angelman Syndrome, characterized by severe motor and intellectual retardation, ataxia, hypotonia, epilepsy, absence of speech, and characteristic facies. The protein also interacts with the E6 protein of human papillomavirus types 16 and 18, resulting in ubiquitination and proteolysis of tumor protein p53. Alternative splicing of this gene results in three transcript variants encoding three isoforms with different N-termini. Additional transcript variants have been described, but their full length nature has not been determined.
ubiquitin protein ligase E3A
, drosophila angelman syndrome
, angelman syndrome
, ubiquitin protein ligase E3A (human papilloma virus E6-associated protein, Angelman syndrome)
, ubiquitin-protein ligase E3A
, ubiquitin-protein ligase E3A-like
, CTCL tumor antigen se37-2
, E6AP ubiquitin-protein ligase
, human papilloma virus E6-associated protein
, human papillomavirus E6-associated protein
, oncogenic protein-associated protein E6-AP
, renal carcinoma antigen NY-REN-54
, E6-AP ubiquitin protein ligase
, ubiquitin conjugating enzyme E3A