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Ubiquitin Protein Ligase E3A Proteins (ube3a)

ube3a encodes an E3 ubiquitin-protein ligase, part of the ubiquitin protein degradation system. Additionally we are shipping ube3a Antibodies (73) and ube3a Kits (12) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
ube3a 7337 Q05086
Mouse ube3a ube3a 22215  
Rat ube3a ube3a 361585  
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Top ube3a Proteins at

Showing 6 out of 8 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
HOST_Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific pu... 1 mg Log in to see 39 to 44 Days
HOST_Escherichia coli (E. coli) Human His tag,T7 tag 100 μg Log in to see 11 to 13 Days
HOST_Wheat germ Human GST tag 10 μg Log in to see 9 Days
HOST_Sf-21 Cells Human His tag   50 μg Log in to see 5 to 8 Days
HOST_Escherichia coli (E. coli) Human Un-conjugated   100 μg Log in to see 9 to 19 Days
HOST_Human Human Un-conjugated   20 μg Log in to see 9 to 11 Days

ube3a Proteins by Origin and Source

Origin Expressed in Conjugate
Human , , ,
, ,

More Proteins for Ubiquitin Protein Ligase E3A (ube3a) Interaction Partners

Fruit Fly (Drosophila melanogaster) Ubiquitin Protein Ligase E3A (ube3a) interaction partners

  1. Data indicate that E3 ligase called ube3 (dube3a) is required for brain development as mutants have defective mushroom bodies.

  2. Rpn10 is targeted for degradation by Ube3a.

  3. In Drosophila melanogaster the human homologue ube3a regulates the actin cytoskeleton and neuronal homeostasis.

  4. MeCP2 (show MECP2 Proteins) and E6AP play a role in the transcriptional control of common target gene expression.

  5. Ube3a regulates serotonin and dopamine synthesis in the fly brain by increasing GTP cyclohydrolase I (show GCH1 Proteins) activity.

  6. dube3a null mutants appear normal externally, but display abnormal locomotive behavior and circadian rhythms, and defective long-term memory; overexpression in the nervous system caused locomotion defects, dependent on the ubiquitin ligase activity

  7. Overexpression of dUBE3A decreased dendritic branching.

Human Ubiquitin Protein Ligase E3A (ube3a) interaction partners

  1. The observation of Dup15q syndrome in individuals with maternally but not paternally inherited duplications of chromosome 15q11-q13, suggest that UBE3A drives the Angelman syndrome phenotype in this disorder. (Review)

  2. our results indicate that CSN6 (show COPS6 Proteins) is a positive regulator of E6AP and is important for cervical cancer development.

  3. Stable over-expression of E6-AP increases the proliferation and invasion of prostate tumor cells.

  4. Impairments in both synaptic plasticity and fear conditioning memory in UBE3A-deficient mice are significantly ameliorated by blocking SK2. These results elucidate a mechanism by which UBE3A directly influences cognitive function.

  5. Study describes an upstream regulatory mechanism for UBE3A and provides a comprehensive understanding of how missense mutations linked to Angelman syndrome and autism affect UBE3A protein function.

  6. The miR (show MLXIP Proteins)-375-UBE3A axis is important in modulating radiosensitivity of HR-HPV (+) cervical cancer.

  7. UBE3A dampens ERK (show EPHB2 Proteins) pathway signalling in HPV E6 transformed HeLa cells

  8. crystal structure of a ternary complex comprising full-length human papilloma virus type 16 (HPV-16) E6, the LxxLL motif of E6AP and the core domain of p53 (show TP53 Proteins)

  9. UBE3A may regulate the expression of annexin A2 (show ANXA2 Proteins), resulting in promotion of proliferation and invasion and suppression of apoptosis in breast cancer cells.

  10. The activity of E6AP is controlled by noncovalent interactions with ubiquitin and allosteric activators such as the HPV E6 oncoprotein.

Mouse (Murine) Ubiquitin Protein Ligase E3A (ube3a) interaction partners

  1. Results substantiate GABAergic Ube3a loss as the principal cause of circuit hyperexcitability in Angelman syndrome mice, lending insight into ictogenic mechanisms in AS.

  2. Loss of Ube3a from tyrosine hydroxylase (show TH Proteins)-expressing neurons impairs mesoaccumbal, non-canonical GABA co-release and enhances reward-seeking behaviour measured by optical self-stimulation.

  3. Results suggest that the phenotypes observed in Angelman syndrome mice may be modulated by factors independent of Ube3a genotype

  4. UBE3A dampens ERK (show EPHB2 Proteins) pathway signalling in HPV E6 transformed HeLa cells

  5. The normal window of development in Angelman syndrome patients is supported by an incompletely silenced paternal allele in developing neurons, resulting in a relative preservation of Ube3a expression during this crucial epoch of early development.

  6. Inactivation of Ube3a expression elevates BMAL1 (show ARNTL Proteins) levels in brain regions that control circadian behavior of AS-model mice, indicating an important role for Ube3a in modulating BMAL1 (show ARNTL Proteins) turnover.

  7. This study demonstrated that abnormal sleep patterns arise from a deficit in accumulation of sleep drive, uncovering the Ube3a gene as a novel genetic regulator of sleep homeostasis

  8. The deficiency of Ube3a in Huntington's disease (HD) mice brain also caused significant increase in global aggregates load, and these aggregates were less ubiquitinated when compared with age-matched HD mice.

  9. There are distinct neurodevelopmental windows when Ube3a restoration rescues Angelman-syndrome-like phenotypes. Motor deficits are rescued in adolescence. Anxiety, repetitive behavior, and epilepsy are rescued in early development.

  10. Mature oligodendrocytes express Ube3a in the cortex and white matter tracts during development.

Pig (Porcine) Ubiquitin Protein Ligase E3A (ube3a) interaction partners

  1. In the skeletal muscle of neonate pigs, both NECD (show NDN Proteins) and SNRPN (show SNRPN Proteins) were maternally imprinted, while UBE3A was not imprinted.

ube3a Protein Profile

Protein Summary

This gene encodes an E3 ubiquitin-protein ligase, part of the ubiquitin protein degradation system. This imprinted gene is maternally expressed in brain and biallelically expressed in other tissues. Maternally inherited deletion of this gene causes Angelman Syndrome, characterized by severe motor and intellectual retardation, ataxia, hypotonia, epilepsy, absence of speech, and characteristic facies. The protein also interacts with the E6 protein of human papillomavirus types 16 and 18, resulting in ubiquitination and proteolysis of tumor protein p53. Alternative splicing of this gene results in three transcript variants encoding three isoforms with different N-termini. Additional transcript variants have been described, but their full length nature has not been determined.

Gene names and symbols associated with ube3a

  • Ubiquitin protein ligase E3A (Ube3a)
  • ubiquitin protein ligase E3A (UBE3A)
  • ubiquitin-protein ligase E3A (ube3a)
  • ubiquitin protein ligase E3A (ube3a)
  • ubiquitin protein ligase E3A (human papilloma virus E6-associated protein, Angelman syndrome) (ube3a)
  • ubiquitin protein ligase E3A (Eint_040430)
  • ubiquitin protein ligase E3A (Ube3a)
  • 4732496B02 protein
  • 5830462N02Rik protein
  • A130086L21Rik protein
  • ANCR protein
  • As protein
  • CG6190 protein
  • das protein
  • DDBDRAFT_0188760 protein
  • DDBDRAFT_0302447 protein
  • DDB_0188760 protein
  • DDB_0302447 protein
  • DKFZp459N106 protein
  • Dmel\\CG6190 protein
  • dube3a protein
  • E6-AP protein
  • EPVE6AP protein
  • Hpve6a protein
  • im:7140733 protein
  • MGC69536 protein
  • mKIAA4216 protein
  • ube3a protein
  • UME3A protein
  • zgc:92173 protein

Protein level used designations for ube3a

ubiquitin protein ligase E3A , CG6190-PA , Ube3a-PA , drosophila angelman syndrome , angelman syndrome , ubiquitin protein ligase E3A (human papilloma virus E6-associated protein, Angelman syndrome) , ubiquitin-protein ligase E3A , ubiquitin-protein ligase E3A-like , CTCL tumor antigen se37-2 , E6AP ubiquitin-protein ligase , human papilloma virus E6-associated protein , human papillomavirus E6-associated protein , oncogenic protein-associated protein E6-AP , renal carcinoma antigen NY-REN-54 , E6-AP ubiquitin protein ligase , ubiquitin conjugating enzyme E3A

39266 Drosophila melanogaster
453269 Pan troglodytes
479010 Canis lupus familiaris
8627519 Dictyostelium discoideum AX4
100173699 Pongo abelii
100194730 Salmo salar
407881 Xenopus (Silurana) tropicalis
9699096 Encephalitozoon intestinalis ATCC 50506
100050725 Equus caballus
100385816 Callithrix jacchus
100438681 Pongo abelii
7337 Homo sapiens
22215 Mus musculus
792398 Danio rerio
533136 Bos taurus
361585 Rattus norvegicus
100522589 Sus scrofa
418686 Gallus gallus
100342825 Oryctolagus cuniculus
100730511 Cavia porcellus
380385 Xenopus laevis
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