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Deubiquitinase that mediates deubiquitination of target proteins such as BECN1, MITF, SKP2 and USP10 and is involved in various processes such as autophagy and endoplasmic reticulum- associated degradation (ERAD). Additionally we are shipping USP13 Proteins (3) and many more products for this protein.
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Human Polyclonal USP13 Primary Antibody for ICC, IF - ABIN4364543
Cheung, Yang, Lee, Rennert, Chan: Hypermethylation of genes in testicular embryonal carcinomas. in British journal of cancer 2016
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our results demonstrate that AR can promote melanoma metastasis via altering the miRNA-539-3p/USP13/MITF (show MITF Antibodies)/AXL (show AXL Antibodies) signal and targeting this newly identified signal with AR degradation enhancer ASC (show PYCARD Antibodies)-J9 may help us to better suppress the melanoma metastasis.
USP13 and FBXL14 (show FBXL14 Antibodies) play opposing roles in the regulation of glioma stem cells (GSCs) through reversible ubiquitination of c-Myc (show MYC Antibodies).
Down-regulation of USP13 mediates PTEN (show PTEN Antibodies) protein loss and fibroblast phenotypic change, and thereby plays a crucial role in idiopathic pulmonary fibrosis pathogenesis.
The authors identify USP13 as a gp78 (show AMFR Antibodies)-associated deubiquitinase that eliminates ubiquitin conjugates from Ubl4A (show UBL4A Antibodies) to maintain the functionality of Bag6 (show BAT3 Antibodies).
USP13 is a tumour-suppressing protein that functions through deubiquitylation and stabilization of PTEN (show PTEN Antibodies).
to our knowledge, USP13 is the first deubiquitinating enzymes identified to modulate STAT1 and play a role in the antiviral activity of IFN against DEN-2 replication.
USP10 (show USP10 Antibodies) mediates the deubiquitination of p53 (show TP53 Antibodies), regulating deubiquitination activity of USP10 (show USP10 Antibodies) and USP13 by Beclin1 (show BECN1 Antibodies) provides a mechanism for Beclin1 (show BECN1 Antibodies) to control the levels of p53 (show TP53 Antibodies).
Through deubiquitination, USP13 stabilizes and upregulates MITF (show MITF Antibodies) protein levels.
study identifies a new layer of Siah2 (show SIAH2 Antibodies) regulation mediated by USP13 binding to ubiquitinated Siah2 (show SIAH2 Antibodies) protein with a concomitant inhibitory effect on its activity under normoxia
Deubiquitinase that mediates deubiquitination of target proteins such as BECN1, MITF, SKP2 and USP10 and is involved in various processes such as autophagy and endoplasmic reticulum- associated degradation (ERAD). Component of a regulatory loop that of BECN1, a key regulator of autophagy, leading to stabilize the PIK3C3/VPS34-containing complexes. Also deubiquitinates USP10, an essential regulator of p53/TP53 stability. In turn, PIK3C3/VPS34- containing complexes regulate USP13 stability, suggesting the existence of a regulatory system by which PIK3C3/VPS34-containing complexes regulate p53/TP53 protein levels via USP10 and USP13. Recruited by nuclear UFD1 and mediates deubiquitination of SKP2, thereby regulating endoplasmic reticulum-associated degradation (ERAD). Mediates stabilization of SIAH2 independently of impairing SIAH2 autoubiquitination. Has a weak deubiquitinase activity in vitro and preferentially cleaves 'Lys-63'-linked polyubiquitin chains. In contrast to USP5, it is not able to mediate unanchored polyubiquitin disassembly. Able to cleave ISG15 in vitro\; however, additional experiments are required to confirm such data (By similarity).
deubiquitinating enzyme 13
, isopeptidase T-3
, ubiquitin carboxyl-terminal hydrolase 13
, ubiquitin specific protease 13 (isopeptidase T-3)
, ubiquitin thioesterase 13
, ubiquitin thiolesterase 13
, ubiquitin-specific-processing protease 13
, ubiquitin specific peptidase 13 (isopeptidase T-3)
, ubiquitin carboxyl-terminal hydrolase 13-like
, ubiquitin thiolesterase 13-like
, Deubiquitinating enzyme 13
, Ubiquitin thioesterase 13
, Ubiquitin-specific-processing protease 13
, ubiquitin specific peptidase 13
, universal stress protein