anti-Ubiquitin Specific Peptidase 7 (Herpes Virus-Associated) (USP7) Antibodies

Hydrolase that deubiquitinates target proteins such as FOXO4, p53/TP53, MDM2, ERCC6, PTEN and DAXX. Additionally we are shipping USP7 Proteins (9) and many more products for this protein.

list all antibodies Gene Name GeneID UniProt
USP7 252870 Q6A4J8
USP7 7874 Q93009
USP7 360471 Q4VSI4
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Top anti-USP7 Antibodies at antibodies-online.com

Showing 10 out of 168 products:

Catalog No. Reactivity Host Conjugate Application Images Quantity Supplier Delivery Price Details
Human Rabbit Un-conjugated EIA, IHC (p), WB 0.4 mL Log in to see 6 to 8 Days
$390.50
Details
Human Rabbit Un-conjugated EIA, WB USP7 Antibody (Center) western blot analysis in A2058 cell line lysates (35 µg/lane). This demonstrates the USP7 antibody detected the USP7 protein (arrow). 0.4 mL Log in to see 6 to 8 Days
$390.50
Details
Human Rabbit Un-conjugated ICC, IF, IHC (p), IP, IHC, PLA, WB Western Blot: USP7 Antibody [ABIN151954] - Detection of Human and Mouse USP7 by Western Blot (h and m) and Immunoprecipitation (h). Samples: Whole cell lysate from HeLa (5, 15 and 50 ug for WB; 1 mg for IP, 20% of IP loaded), 293T (T; 50 ug) and mouse NIH3T3 (M; 50 ug) cells. Antibodies: Affinity purified rabbit anti-USP7 antibody ABIN151954 (lot ABIN151954-3) used for WB at 0.1 ug/ml (A) and 1 ug/ml (B) and used for IP at 3 ug/mg lysate. USP7 was also immunoprecipitated by a previous lot (lot ABIN151954-2) of this antibody. Detection: Chemiluminescence with exposure times of 10 seconds (A) and 1 second (B). 100 μL Log in to see 7 to 9 Days
$486.94
Details
Cow Rabbit Un-conjugated WB Host: Rat Target Name: USP7 Sample Tissue: Rat Brain Antibody Dilution: 1ug/ml WB Suggested Anti-USP7 Antibody Titration: 0.2-1 ug/ml ELISA Titer: 1:62500 Positive Control: A549 cell lysate 100 μL Log in to see 2 to 3 Days
$289.00
Details
Chimpanzee Rabbit Un-conjugated EIA, WB   0.1 mg Log in to see 12 to 15 Days
$411.18
Details
Human Mouse Un-conjugated ELISA, WB Figure 1: Western blot analysis using HAUSP mouse mAb against MCF-7 (1) cell lysate. 100 μL Log in to see 2 to 3 Days
$393.80
Details
Human Mouse Un-conjugated IHC (p), WB 100 μL Log in to see 7 to 9 Days
$493.17
Details
Human Mouse Un-conjugated FACS, IHC (p), WB 100 μL Log in to see 7 to 9 Days
$493.17
Details
Human Rabbit Un-conjugated IF (p), IHC (p), WB Formalin-fixed and paraffin embedded human lung (pneumonia) labeled with Anti-HAUSP/USP7 Polyclonal Antibody, Unconjugated (ABIN706346) at 1:200 followed by conjugation to the secondary antibody and DAB staining. 100 μL Log in to see 3 to 7 Days
$295.90
Details
Human Rabbit Un-conjugated IHC (p), WB The anti-USP7 Pab (ABIN388889) is used in Western blot to detect USP7 in T-47D cell lysate. Formalin-fixed and paraffin-embedded human cancer tissue reacted with the primary antibody, which was peroxidase-conjugated to the secondary antibody, followed by AEC staining. BC = breast carcinoma. HC = hepatocarcinoma 400 μL Log in to see 10 to 11 Days
$324.50
Details

USP7 Antibodies by Reactivity, Application, Clonality and Conjugate

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Top referenced anti-USP7 Antibodies

  1. Human Polyclonal USP7 Primary Antibody for ICC, IF - ABIN151954 : Canning, Boutell, Parkinson, Everett: A RING finger ubiquitin ligase is protected from autocatalyzed ubiquitination and degradation by binding to ubiquitin-specific protease USP7. in The Journal of biological chemistry 2004 (PubMed)
    Show all 25 references for 151954

  2. Human Polyclonal USP7 Primary Antibody for EIA, WB - ABIN955493 : Sarkari, La Delfa, Arrowsmith, Frappier, Sheng, Saridakis: Further insight into substrate recognition by USP7: structural and biochemical analysis of the HdmX and Hdm2 interactions with USP7. in Journal of molecular biology 2010 (PubMed)
    Show all 5 references for 955493

  3. Human Polyclonal USP7 Primary Antibody for EIA, IHC (p) - ABIN357533 : Puente, Sánchez, Overall, López-Otín: Human and mouse proteases: a comparative genomic approach. in Nature reviews. Genetics 2003 (PubMed)
    Show all 5 references for 357533

  4. Human Monoclonal USP7 Primary Antibody for ELISA, WB - ABIN969186 : Becker, Marchenko, Maurice, Moll: Hyperubiquitylation of wild-type p53 contributes to cytoplasmic sequestration in neuroblastoma. in Cell death and differentiation 2007 (PubMed)
    Show all 3 references for 969186

  5. Cow (Bovine) Polyclonal USP7 Primary Antibody for WB - ABIN2787924 : Nie, Zhang, Dai, Zhang, Zhao, Xu, Chen, Wang, Wang, Qiao: Nicotine Induced Murine Spermatozoa Apoptosis via Up-Regulation of Deubiquitinated RIP1 by Trim27 Promoter Hypomethylation. in Biology of reproduction 2016 (PubMed)

More Antibodies against USP7 Interaction Partners

Fruit Fly (Drosophila melanogaster) Ubiquitin Specific Peptidase 7 (Herpes Virus-Associated) (USP7) interaction partners

  1. reveal a conserved mechanism by which Ci/Gli (show GLI1 Antibodies) is stabilized by a deubiquitination enzyme and identify Usp7/HUASP as a critical regulator of Hh signaling and potential therapeutic target for Hh-related cancers

  2. Genetic and gene expression analyses suggested that GMPS (show GMPS Antibodies)/USP7 acts as a transcriptional corepressor

  3. GMP synthetase (show GMPS Antibodies) stimulates histone H2B deubiquitylation by the epigenetic silencer USP7

Mouse (Murine) Ubiquitin Specific Peptidase 7 (Herpes Virus-Associated) (USP7) interaction partners

  1. EPOP (E130012A19Rik) interacts with elongin B (show TCEB2 Antibodies), elongin C (show TCEB1 Antibodies), and USP7 to modulate the chromatin landscape.

  2. USP7 is overexpressed and regulates homologous recombination repair in chronic lymphocytic leukemia cells.

  3. Findings demonstrate a crucial role of HAUSP in regulating N-Myc (show MYCN Antibodies) function in neuroblastoma (show ARHGEF16 Antibodies) in vivo and suggest that HAUSP inhibition is a potential therapy for MYCN (show MYCN Antibodies)-amplified tumors.

  4. The present study identified USP7 and TDP-43 (show TARDBP Antibodies) as the regulators of CRY1 (show CRY1 Antibodies) and CRY2 (show CRY2 Antibodies), underscoring the significance of the stability control process of CRY (show CRY2 Antibodies) proteins for period determination in the mammalian circadian clockwork.

  5. demonstrate that genotoxic stress stimulates Cry1 (show CRY1 Antibodies) phosphorylation and its deubiquitination by Herpes virus associated ubiquitin-specific protease (Hausp, a.k.a Usp7), stabilizing Cry1 (show CRY1 Antibodies) and shifting circadian clock time

  6. Our results demonstrate that the SCML2 (show SCML2 Antibodies)/USP7 complex constitutes a novel molecular pathway in modulating the epigenetic state of sex chromosomes during male meiosis

  7. USP7-mediated mono-deubiquitination of FoxO1 (show FOXO1 Antibodies) results in suppression of FoxO1 (show FOXO1 Antibodies) transcriptional activity through decreased FoxO1 (show FOXO1 Antibodies) occupancy on the promoters of gluconeogenic genes.

  8. Early adipogenesis is regulated through USP7-mediated deubiquitination of the histone acetyltransferase TIP60 (show KAT5 Antibodies).

  9. The ubiquitination-deubiquitination cascade mediated by the TRIM27 (show RFP Antibodies)-USP7 complex plays an important role in TNF-alpha (show TNF Antibodies)-induced apoptosis.

  10. the stability and activity of PPARgamma2 (show PPARG Antibodies) are modulated by the deubiquitinating activity of HAUSP, which may be a target for the development of anti-diabetic drugs.

Human Ubiquitin Specific Peptidase 7 (Herpes Virus-Associated) (USP7) interaction partners

  1. Molecular mechanisms of USP7 substrate recognition and C-terminal activation have been described.

  2. USP7 promotes breast carcinogenesis by stabilizing PHF8 (show PHF8 Antibodies) and upregulating cyclin A2 (show CCNA2 Antibodies). and the interaction between USP7 and PHF8 (show PHF8 Antibodies) is augmented during DNA damage.

  3. Data suggest that SIRT7 (show SIRT7 Antibodies) undergoes Lys (show LYZ Antibodies)-63 polyubiquitination, later removed by USP7 to repress enzymatic activity of SIRT7 (show SIRT7 Antibodies); USP7 and SIRT7 (show SIRT7 Antibodies) regulate gluconeogenesis via expression of glucose-6-phosphatase catalytic subunit (G6PC (show G6PC Antibodies)); SIRT7 (show SIRT7 Antibodies) targets G6PC (show G6PC Antibodies) promoter through ELK4 (show ELK4 Antibodies). (SIRT7 (show SIRT7 Antibodies) = sirtuin 7 (show SIRT7 Antibodies); USP7 = ubiquitin specific peptidase 7; G6PC (show G6PC Antibodies) = glucose-6-phosphatase catalytic subunit (show G6PC Antibodies); ELK4 (show ELK4 Antibodies) = transcription factor ELK4 (show ELK4 Antibodies))

  4. USP7 is overexpressed and regulates homologous recombination repair in chronic lymphocytic leukemia cells.

  5. Findings demonstrate a crucial role of HAUSP in regulating N-Myc (show MYCN Antibodies) function in neuroblastoma (show ARHGEF16 Antibodies) in vivo and suggest that HAUSP inhibition is a potential therapy for MYCN (show MYCN Antibodies)-amplified tumors.

  6. findings suggest that Usp7 is important for MB cell proliferation and metastasis by activating Shh (show SHH Antibodies) pathway, and is a putative therapeutic target for MBs (show PPP1R12A Antibodies)

  7. Data suggest that HIV-1 (human immunodeficiency virus type 1) Tat (show TAT Antibodies) gene product is stabilized by host cell deubiquitinase USP7, leading to enhanced viral production; HIV-1 in turn up-regulates the USP7 protein expression in human T-lymphocytes.

  8. modulatory role for Trip12 (show TRIP12 Antibodies) in the USP7-dependent DNA damage response

  9. WDR79 (show WRAP53 Antibodies) colocalized and interacted with USP7 in the nucleus of non-small cell lung cancer cells. This event, in turn, reduced the ubiquitination of Mdm2 (show MDM2 Antibodies) and p53 (show TP53 Antibodies), thereby increasing the stability and extending the half-life of the two proteins.

  10. USP7 and MARCH7 are involved in the progression of Epithelial ovarian cancer.

USP7 Antigen Profile

Protein Summary

Hydrolase that deubiquitinates target proteins such as FOXO4, p53/TP53, MDM2, ERCC6, PTEN and DAXX. Together with DAXX, prevents MDM2 self-ubiquitination and enhances the E3 ligase activity of MDM2 towards p53/TP53, thereby promoting p53/TP53 ubiquitination and proteasomal degradation. Deubiquitinates p53/TP53 and MDM2 and strongly stabilizes p53/TP53 even in the presence of excess MDM2, and also induces p53/TP53-dependent cell growth repression and apoptosis. Deubiquitination of FOXO4 in presence of hydrogen peroxide is not dependent on p53/TP53 and inhibits FOXO4-induced transcriptional activity. In association with DAXX, is involved in the deubiquitination and translocation of PTEN from the nucleus to the cytoplasm, both processes that are counteracted by PML. Involved in cell proliferation during early embryonic development. Involved in transcription-coupled recruited to DNA damage sites following interaction with KIAA1530/UVSSA and promotes deubiquitination of ERCC6, preventing UV-induced degradation of ERCC6 (By similarity).

Gene names and symbols associated with USP7

  • ubiquitin-specific protease 7 (Usp7) antibody
  • ubiquitin specific peptidase 7 (herpes virus-associated) (usp7) antibody
  • ubiquitin specific peptidase 7 (herpes virus-associated) (USP7) antibody
  • ubiquitin specific peptidase 7 (Usp7) antibody
  • ubiquitin specific peptidase 7 (herpes virus-associated) (Usp7) antibody
  • 2210010O09Rik antibody
  • AA409944 antibody
  • AA617399 antibody
  • AU019296 antibody
  • AW548146 antibody
  • C80752 antibody
  • CG1490 antibody
  • Dmel\\CG1490 antibody
  • HAUSP antibody
  • TEF1 antibody
  • UBP antibody
  • USP7 antibody

Protein level used designations for USP7

CG1490-PB , Usp7-PB , ubiquitin specific peptidase 7 (herpes virus-associated) , ubiquitin carboxyl-terminal hydrolase 7-like , deubiquitinating enzyme 7 , herpesvirus-associated ubiquitin-specific protease , mHAUSP , ubiquitin carboxyl-terminal hydrolase 7 , ubiquitin specific protease 7 , ubiquitin thioesterase 7 , ubiquitin thiolesterase 7 , ubiquitin-specific-processing protease 7 , Herpes virus-associated ubiquitin-specific protease , ubiquitin specific protease 7 (herpes virus-associated) , herpes-virus-associated ubiquitin-specific protease , rHAUSP , ubiquitin-specific peptidase 7

GENE ID SPECIES
32169 Drosophila melanogaster
100201254 Hydra magnipapillata
100468835 Ailuropoda melanoleuca
252870 Mus musculus
7874 Homo sapiens
360471 Rattus norvegicus
395126 Gallus gallus
479854 Canis lupus familiaris
100190899 Sus scrofa
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