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Upstream Binding Transcription Factor, RNA Polymerase I Proteins (UBTF)

UBTF encodes a member of the HMG-box DNA-binding protein family. Additionally we are shipping Upstream Binding Transcription Factor, RNA Polymerase I Antibodies (88) and Upstream Binding Transcription Factor, RNA Polymerase I Kits (4) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
UBTF 7343 P17480
Mouse UBTF UBTF 21429  
UBTF 25574 P25977
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Top Upstream Binding Transcription Factor, RNA Polymerase I Proteins at antibodies-online.com

Showing 4 out of 4 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
HOST_Wheat germ Human GST tag 10 μg Log in to see 9 Days
$405.71
Details
HOST_Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 39 to 44 Days
$9,248.02
Details
Yeast Rat His tag   1 mg Log in to see 56 to 66 Days
$4,238.67
Details
HOST_Human Human Un-conjugated   20 μg Log in to see 9 to 11 Days
$785.40
Details

UBTF Proteins by Origin and Source

Origin Expressed in Conjugate
Human , ,
,
Rat (Rattus)

Top referenced Upstream Binding Transcription Factor, RNA Polymerase I Proteins

  1. Human UBTF Protein expressed in Wheat germ - ABIN1324490 : Østrup, Hyttel, Klærke, Collas: Remodeling of ribosomal genes in somatic cells by Xenopus egg extract. in Biochemical and biophysical research communications 2011 (PubMed)

More Proteins for Upstream Binding Transcription Factor, RNA Polymerase I (UBTF) Interaction Partners

Human Upstream Binding Transcription Factor, RNA Polymerase I (UBTF) interaction partners

  1. This study provides some compelling evidences in support of HBx-elicited and c-Myc (show MYC Proteins)-mediated increase in UBF levels that abets oncogenic onslaught in hepatic cells by increasing rDNA transcription and ribosome biogenesis.

  2. These results suggest that UBF can inhibit gene expression from viral DNA prior to its replication.

  3. we have uncovered a novel role for UBTF1 and UBTF2 in maintaining genome stability through coordinating the expression of highly transcribed Pol I (UBTF1 activity) and Pol II genes (UBTF2 activity).

  4. p14ARF fails to prevent E7-mediated UBF1 phosphorylation, but could facilitate nucleolar pRb (show RB1 Proteins) inactivation by targeting E7 to the nucleolus.

  5. PIP2 depletion reduces Pol I transcription.

  6. UBF is expressed widely by human multiple fetal tissue,s and the expression level is very high in HL-60 cells.

  7. Downregulation of RUNX2 (show RUNX2 Proteins) expression reduces the localization of HDAC1 (show HDAC1 Proteins) to the nucleolar periphery and also decreases the association between HDAC1 (show HDAC1 Proteins) and UBF.

  8. hALP binds the upstream binding factor (UBF) in vivo and in vitro

  9. depletion of upstream binding factor (UBF; an rRNA transcription factor) decreased the chromatin binding affinity of B23 (show NPM1 Proteins), which in turn led to an increase in histone density at the r-chromatin

  10. The three-dimensional solution structure of the first high mobility group (HMG (show SSRP1 Proteins)) box domain in upstream binding factor has been determined by multidimensional NMR.

Mouse (Murine) Upstream Binding Transcription Factor, RNA Polymerase I (UBTF) interaction partners

  1. inhibition of UBF function is a major factor in the cytotoxicity of cisplatin; its depletion selectively induces p53 (show TP53 Proteins)-independent apoptotic death in transformed cells

  2. Loss of UBF also unexpectedly induced the formation in cells of a large sub-nuclear structure resembling the nucleolar precursor body (NPB) of oocytes and early embryos.

  3. we have uncovered a novel role for UBTF1 and UBTF2 in maintaining genome stability through coordinating the expression of highly transcribed Pol I (UBTF1 activity) and Pol II genes (UBTF2 activity).

  4. UBF1 mutation (K352A, K352Q, and K352R) decreased rDNA transcriptional activity.

  5. augmented ribosome biogenesis occurs in UBF-dependent manner during increased protein synthesis induced by high glucose in glomerular epithelial cells that correlates with UBF activation and renal hypertrophy in rodents with type 1 and type 2 diabetes.

  6. increased UBF levels correlate with elevated pressure load and increased cardiac growth rates

  7. mTOR (show FRAP1 Proteins) plays a critical role in the regulation of ribosome biogenesis via a mechanism that requires S6K1 (show RPS6KB1 Proteins) activation and phosphorylation of UBF.

  8. effects of PES1 (show PES1 Proteins) and UBF1 expression on the growth and differentiation of cell lines derived from 32D cells, an interleukin-3 (IL-3 (show Il3 Proteins))-dependent murine myeloid cell line

  9. Phosphatidylinositol 3-kinase subunit directly phosphorylates and activates UBF1, an exclusively nucleolar protein (show MCRS1 Proteins).

  10. Proto-Oncogene (show RAB1A Proteins) Proteins c-myc (show MYC Proteins) activated transcription from the UBF promoter

Upstream Binding Transcription Factor, RNA Polymerase I (UBTF) Protein Profile

Protein Summary

This gene encodes a member of the HMG-box DNA-binding protein family. The encoded protein plays a critical role in ribosomal RNA transcription as a key component of the pre-initiation complex, mediating the recruitment of RNA polymerase I to rDNA promoter regions. The encoded protein may also play important roles in chromatin remodeling and pre-rRNA processing, and its activity is regulated by both phosphorylation and acetylation. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. Pseudogenes of this gene are located on the short arm of chromosomes 3, 11 and X and the long arm of chromosome 11.

Gene names and symbols associated with UBTF

  • upstream binding transcription factor, RNA polymerase I (ubtf)
  • upstream binding transcription factor, RNA polymerase I (UBTF)
  • upstream binding transcription factor, RNA polymerase I (Ubtf)
  • A930005G04Rik protein
  • NOR-90 protein
  • si:dz180g5.3 protein
  • Tcfubf protein
  • ubf protein
  • UBF-1 protein
  • UBF1 protein
  • UBTF protein
  • wu:fj38c10 protein
  • xUBF protein

Protein level used designations for UBTF

upstream binding transcription factor, RNA polymerase I , nucleolar transcription factor 1-like , 90-kDa nucleolus organizer region autoantigen , autoantigen NOR-90 , nucleolar transcription factor 1 , UBF-1 , transcription factor UBF , upstream-binding factor 1

GENE ID SPECIES
368509 Danio rerio
454726 Pan troglodytes
497012 Bos taurus
100019759 Monodelphis domestica
100064724 Equus caballus
100135747 Xenopus (Silurana) tropicalis
100454637 Pongo abelii
100483006 Ailuropoda melanoleuca
100511403 Sus scrofa
100558152 Anolis carolinensis
7343 Homo sapiens
21429 Mus musculus
25574 Rattus norvegicus
480503 Canis lupus familiaris
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