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Uridine Phosphorylase 1 Proteins (UPP1)

The 2 known types of pyrimidine nucleoside phosphorylases, uridine phosphorylase (UP\; EC 2.4.2.3) and thymidine phosphorylase (TP\; EC 2.4.2.4), in the presence of orthophosphate, catalyze the reversible phosphorolysis of uridine and thymidine or deoxyuridine, respectively, to free bases and ribose-1-phosphate or deoxyribose-1-phosphate. Additionally we are shipping UPP1 Antibodies (17) and UPP1 Kits (11) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
UPP1 7378 Q16831
Mouse UPP1 UPP1 22271 P52624
Rat UPP1 UPP1 289801  
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Top UPP1 Proteins at antibodies-online.com

Showing 8 out of 11 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
HOST_Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
HOST_Escherichia coli (E. coli) Human His tag 50 μg Log in to see 7 to 8 Days
$407.00
Details
HOST_Escherichia coli (E. coli) Human His tag   50 μg Log in to see 5 Days
$385.00
Details
HOST_Wheat germ Human GST tag 10 μg Log in to see 9 Days
$405.71
Details
HOST_Escherichia coli (E. coli) Human Un-conjugated   50 μg Log in to see 3 to 4 Days
$467.86
Details
HOST_Human Human Un-conjugated   20 μg Log in to see 9 to 11 Days
$785.40
Details
HOST_Escherichia coli (E. coli) REACT_Salmonella typhimurium Un-conjugated   50 μg Log in to see 9 to 19 Days
$385.52
Details
HOST_Escherichia coli (E. coli) REACT_Escherichia coli Un-conjugated   1 mg Log in to see 9 to 19 Days
$3,878.85
Details

UPP1 Proteins by Origin and Source

Origin Expressed in Conjugate
Human , ,
,

Top referenced UPP1 Proteins

  1. Human UPP1 Protein expressed in Escherichia coli (E. coli) - ABIN667819 : Kanzaki, Takebayashi, Bando, Eliason, Watanabe Si, Miyashita, Fukumoto, Toi, Uchida: Expression of uridine and thymidine phosphorylase genes in human breast carcinoma. in International journal of cancer. Journal international du cancer 2002 (PubMed)
    Show all 2 references for ABIN667819

More Proteins for Uridine Phosphorylase 1 (UPP1) Interaction Partners

Human Uridine Phosphorylase 1 (UPP1) interaction partners

  1. Data show that enhanced cytotoxicity of 5-FU by bFGF (show FGF2 Proteins) through modulating the expression of UPP1 at the transcription level.

  2. The expression level of UPase gene may be an independent prognostic marker in human breast carcinoma

  3. Characterization of the promoter region of UPase has indicated a direct regulation of its expression by the tumor suppressor gene p53 (show TP53 Proteins). Review.

  4. Thymidine phosphorylase (show TYMP Proteins) and uridine phosphorylase were both responsible for converting 5'dFUrd/5FU into 5FU/FUrd, respectively

  5. The presented structures confirm that hUPP1 (show PTP4A2 Proteins) is dimeric. They also reveal the mechanism by which 5-benzylacyclouridine engages the active site of the protein and disables the enzyme by locking the protein in a closed conformation.

Mouse (Murine) Uridine Phosphorylase 1 (UPP1) interaction partners

  1. Importance of UPase in the activation of fluoropyrimidines, the effect of uridine in protecting normal tissues, and the role for tumor-specific modulation of the phosphorolytic activity in 5-FU or capecitabine-based chemotherapy.

  2. Data show that enhanced cytotoxicity of 5-FU by bFGF (show FGF2 Proteins) through modulating the expression of UPP1 at the transcription level.

  3. Targeted deletion of both thymidine phosphorylase (show TYMP Proteins) and uridine phosphorylase and consequent disorders in mice.

  4. UPase is a critical enzyme in the regulation of uridine homeostasis and pyrimidine nucleotide metabolism, and 5-fluorouracil activity

  5. Taken together, the present study provides the first evidence that uridine protects neurons against ischemic insult-induced neuronal death, possibly through the action of UPase.

  6. Thymidine phosphorylase (show TYMP Proteins) and UPP1 double knockout mice showed increased thymidine and deoxyuridine in tissues and developed encephalopathy.

UPP1 Protein Profile

Protein Summary

The 2 known types of pyrimidine nucleoside phosphorylases, uridine phosphorylase (UP\; EC 2.4.2.3) and thymidine phosphorylase (TP\; EC 2.4.2.4), in the presence of orthophosphate, catalyze the reversible phosphorolysis of uridine and thymidine or deoxyuridine, respectively, to free bases and ribose-1-phosphate or deoxyribose-1-phosphate. Pyrimidine nucleoside phosphorylases can add ribose or deoxyribose to pyrimidine bases to form nucleosides that can be incorporated into RNA or DNA (Watanabe and Uchida, 1995

Gene names and symbols associated with Uridine Phosphorylase 1 Proteins (UPP1)

  • uridine phosphorylase 1 (upp1)
  • uridine phosphorylase 1 (udp_1)
  • uridine phosphorylase 1 (Tsp_02326)
  • Uridine phosphorylase 1 (upp1)
  • uridine phosphorylase 1 (LOC100224766)
  • uridine phosphorylase 1 (UPP1)
  • uridine phosphorylase 1 (Upp1)
  • uridine phosphorylase 1-like (LOC100625277)
  • uridine phosphorylase 1-like (LOC100357952)
  • AI325217 protein
  • im:6911242 protein
  • UdRPase protein
  • Up protein
  • UPase protein
  • Upp protein
  • upp1 protein
  • zgc:110755 protein

Protein level used designations for Uridine Phosphorylase 1 Proteins (UPP1)

uridine phosphorylase 1 , Uridine phosphorylase 1 , UPase 1 , urdPase 1

GENE ID SPECIES
496532 Xenopus (Silurana) tropicalis
3703440 Natronomonas pharaonis DSM 2160
10907966 Trichinella spiralis
100196719 Salmo salar
100224766 Taeniopygia guttata
100528868 Ictalurus punctatus
7378 Homo sapiens
503707 Danio rerio
420942 Gallus gallus
515029 Bos taurus
22271 Mus musculus
289801 Rattus norvegicus
100727838 Cavia porcellus
100625277 Sus scrofa
100357952 Oryctolagus cuniculus
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