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MOS is a serine/threonine kinase that activates the MAP kinase cascade through direct phosphorylation of the MAP kinase activator MEK (MAP2K1\; MIM 176872) (Prasad et al., 2008 [PubMed 18246541]).[supplied by OMIM, Jul 2009].. Additionally we are shipping MOS Antibodies (100) and many more products for this protein.
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while cyclin B1 RNA granules were disassembled in a manner dependent on actin filament depolymerization, certain fractions of mos RNA granules were disassembled independently of actin filaments. These results suggest that cytoplasmic regulation of translationally repressed mRNAs by formation of different RNA granules is a key mechanism for translational control of
employed genetic linkage analysis and physical mapping to place the mosm188 mutation on chromosome 6 in the vicinity of the foxd3 (show FOXD3 Proteins) gene
In Xenopus oocytes, the N-terminal Pro of murine & Xenopus c-MOS is dispensable for degradation if Ser-2 of c-MOS is replaced by a small non-phosphorylatable residue. The N-terminal Pro residue is not a recognition determinant for a ubiquitin ligase.
Mos protein is unstable in early mouse embryos
This suggests that c-mos might play important roles in spermatogenesis
Cdc2 (show CDK1 Proteins) and Mos regulate Emi2 stability to promote the meiosis I-meiosis II transition
Mos is responsible for the mitotic activation of the p42 MAPK (show MAPK1 Proteins) pathway in Xenopus egg extracts.
Results suggest that the specific synthesis of either B-type cyclins or c-Mos, induced by progesterone, is required to induce meiotic maturation and Cdc2 activation.
Thus, Mos and Erp1 (show FBXO43 Proteins) collaboratively establish and maintain metaphase II arrest in Xenopus eggs
results clarify the direct link of the classical Mos-MAPK pathw (show MAPK1 Proteins)ay to Erp1 in meiotic arrest of ve (show MAPK1 Proteins)rtebrate oocytes
approach identified 18 kinase and kinase-related genes whose overexpression can substitute for EGFR (show EGFR Proteins) in EGFR (show EGFR Proteins)-dependent PC9 (show PCSK9 Proteins) cells, and these genes include seven of nine Src (show SRC Proteins) family kinase genes, FGFR1 (show FGFR1 Proteins), FGFR2 (show FGFR2 Proteins), ITK (show ITK Proteins), NTRK1 (show NTRK1 Proteins), NTRK2 (show NTRK2 Proteins), MOS, MST1R (show MST1R Proteins), and RAF1 (show RAF1 Proteins).
High methylation level in MOS is associated with intestinal metaplasia.
among the candidate genes, DNA methylation (show HELLS Proteins) of MOS may reflect the duration of H. pylori exposure and may be a marker for the development of gastric cancer.
In the absence of p53 (show TP53 Proteins), Mos knockdown prevents multipolar mitoses and exerts genome-stabilizing effects.
multiple meiotic genes are aberrantly activated during mitotic catastrophe in p53 (show TP53 Proteins) mutated lymphoma cells after irradiation; the coordinated expression of MOS and REC8 (show REC8 Proteins) regulate the extent of arrested mitoses and polyploidy
Mos 3' UTR regulatory differences underlie species-specific temporal patterns of Mos mRNA cytoplasmic polyadenylation and translational recruitment during oocyte maturation.
Cdc2 (show CDK1 Proteins) and Mos regulate Emi2 (show FBXO43 Proteins) stability to promote the meiosis I-meiosis II transition
These results clarify the direct link of the classical Mos-MAPK (show MAPK1 Proteins) (mitogen-activated protein kinase (show MAPK1 Proteins)) pathway to Erp1 (show FBXO43 Proteins) in meiotic arrest of vertebrate oocytes.
the Mos/MAPK (show MAPK1 Proteins) pathway is not essential for initiating goldfish oocyte maturation despite its general function as a cytostatic factor (CSF (show CSF2 Proteins)).
the length of the MOS 3'-UTR tightly controls the level of translation during oocyte maturation. two U-rich (U5A) elements and the hexanucleotide signal (AAUAAA) are required for translation.
MOS is a serine/threonine kinase that activates the MAP kinase cascade through direct phosphorylation of the MAP kinase activator MEK (MAP2K1\; MIM 176872) (Prasad et al., 2008
v-mos Moloney murine sarcoma viral oncogene homolog
, proto-oncogene serine/threonine-protein kinase mos
, Moloney murine sarcoma viral (v-mos) oncogene homolog
, oocyte maturation factor mos
, proto-oncogene c-Mos
, v-mos moloney murine sarcoma viral oncogene homolog
, c-mos proto-oncogene
, c-mos oncogene
, serine/threonine-protein kinase mos
, oncogene MOS, Moloney murine sarcoma virus
, oocyte maturation factor Mos