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VRK1 encodes a member of the vaccinia-related kinase (VRK) family of serine/threonine protein kinases. Additionally we are shipping Vaccinia Related Kinase 1 Proteins (13) and Vaccinia Related Kinase 1 Kits (6) and many more products for this protein.
Showing 10 out of 69 products:
Human Polyclonal VRK1 Primary Antibody for ICC, IF - ABIN4365869
Sanz-García, Monsalve, Sevilla, Lazo: Vaccinia-related kinase 1 (VRK1) is an upstream nucleosomal kinase required for the assembly of 53BP1 foci in response to ionizing radiation-induced DNA damage. in The Journal of biological chemistry 2012
Show all 6 references for ABIN4365869
Human Monoclonal VRK1 Primary Antibody for WB - ABIN1882291
Barcia, López-Borges, Vega, Lazo: Kinetic properties of p53 phosphorylation by the human vaccinia-related kinase 1. in Archives of biochemistry and biophysics 2002
Show all 5 references for ABIN1882291
Human Polyclonal VRK1 Primary Antibody for EIA, WB - ABIN359566
Nezu, Oku, Jones, Shimane: Identification of two novel human putative serine/threonine kinases, VRK1 and VRK2, with structural similarity to vaccinia virus B1R kinase. in Genomics 1998
vrk-1 has a role in early uterine development in Caenorhabditis elegans
By coordinating VRK-1- and PP2A-mediated signaling on BAF, Lem4 and LEM-4L (Y55F3BR.8) controls postmitotic nuclear envelope formation in a function conserved from worms to humans.
Genome-wide analysis of germ cell proliferation in C. elegans identifies vrk-1 as a key regulator of cep-1/p53 (show TP53 Antibodies).
Data show that expression of the fibroblast growth factor-like protein EGL-17 and its receptor EGL-15 is reduced in vrk-1 mutants, suggesting that VRK-1 might act at least partially through activation of FGF signaling.
VRK1 may act as a tumor promoter by controlling the level of cell cycle regulators associated with G1/S transition and could potentially serve as a therapeutic target and/or prognostic biomarker for HCC (show FAM126A Antibodies).
VRK1 is a novel regulator of CBs (show CBS Antibodies) dynamics and stability in cell cycle by protecting coilin (show COIL Antibodies) from ubiquitination and degradation in the proteasome, and propose a model of CB dynamics.
VRK1 regulation of NBS1 (show NBN Antibodies) contributes to the stability of the repair complex and permits the sequential steps in DNA damage response.
VRK1 is a novel chromatin component that reacts to its alterations and participates very early in DNA damage response, functioning by itself or in cooperation with Ataxia Telangiectasia Mutated (show ATM Antibodies) Proteins.
VRK1 deficiency in human and mouse leads to downregulation of amyloid-beta precursor protein (APP (show APP Antibodies)). APP (show APP Antibodies) overexpression rescues the phenotype caused by Vrk1 knockdown, suggesting that VRK1 affects neuronal migration through an APP (show APP Antibodies)-dependent mechanism.
VRK1 can contribute to make these tumors more resistant to DNA damage-based therapies, such as ionizing radiation or doxorubicin, which is consistent with its association to a poor prognosis in ER positive breast cancer.
VRK1 deficiency disrupts nuclear envelope morphology and leads to BAF (show BANF1 Antibodies) retention on mitotic chromosomes.
The VRK1-p53 (show TP53 Antibodies) basal complex is an early-warning system for immediate cellular responses to DNA damage.
This study identification of disease-causing alleles in 3 children from 2 unrelated families with Mutations in VRK1 associated with complex motor and sensory axonal neuropathy plus microcephaly.
Data from molecular dynamic simulations suggest that bivalent cations play key structural roles in stabilization of VRK1/VRK2; bivalent cations have no obvious effects on VRK3. These kinases are targets in search for antineoplastic agents. [REVIEW]
Data suggest that VRK1 is required for both follicle development and oocyte growth in mammalian female reproduction system.
Protein kinase (show CDK7 Antibodies) Cdelta regulates phosphorylation and down-regulation of Vaccinia-related kinase 1 (VRK1), thereby contributing to cell cycle arrest and apoptotic cell death in a p53 (show TP53 Antibodies)-dependent manner.
reduction of VRK1 activity causes a delay in meiotic progression during oogenesis
VRK1 is required for the proliferation and differentiation of undifferentiated spermatogonia, which are essential for spermatogenic cell maintenance
Depletion of VRK1 leads to progressive male infertility as a result of a cessation of spermatogonial proliferation.
These findings collectively support a role of VRK1 as a novel mitotic histone H3 (show HIST3H3 Antibodies) kinase in mammals.
This gene encodes a member of the vaccinia-related kinase (VRK) family of serine/threonine protein kinases. This gene is widely expressed in human tissues and has increased expression in actively dividing cells, such as those in testis, thymus, fetal liver, and carcinomas. Its protein localizes to the nucleus and has been shown to promote the stability and nuclear accumulation of a transcriptionally active p53 molecule and, in vitro, to phosphorylate Thr18 of p53 and reduce p53 ubiquitination. This gene, therefore, may regulate cell proliferation. This protein also phosphorylates histone, casein, and the transcription factors ATF2 (activating transcription factor 2) and c-JUN.
vaccinia related kinase 1
, serine/threonine-protein kinase VRK1
, serine/threonine-protein kinase VRK1-like
, vaccinia virus B1R-related kinase 1
, vaccinia-related kinase 1
, serine/threonine-protein kinase 51PK