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anti-Vaccinia Related Kinase 1 (VRK1) Antibodies

VRK1 encodes a member of the vaccinia-related kinase (VRK) family of serine/threonine protein kinases. Additionally we are shipping Vaccinia Related Kinase 1 Proteins (13) and Vaccinia Related Kinase 1 Kits (6) and many more products for this protein.

list all antibodies Gene Name GeneID UniProt
VRK1 7443 Q99986
VRK1 22367 Q80X41
VRK1 362779  
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Top anti-Vaccinia Related Kinase 1 Antibodies at antibodies-online.com

Showing 10 out of 69 products:

Catalog No. Reactivity Host Conjugate Application Images Quantity Supplier Delivery Price Details
Human Rabbit Un-conjugated EIA, WB The anti-VRK1 Pab is used in Western blot to detect VRK1 in mouse lung tissue lysate (Lane 1) and HL-60 cell lysate (Lane 2). 0.4 mL Log in to see 6 to 8 Days
$390.50
Details
Human Rabbit Un-conjugated WB The anti-VRK1 Pab (ABIN391605) is used in Western blot to detect VRK1 in mouse lung tissue lysate (Lane 1) and HL-60 cell lysate (Lane 2). Western blot analysis of VRK1 (arrow) using rabbit polyclonal VRK1 Antibody (E381) (ABIN391605). 293 cell lysates (2 µg/lane) either nontransfected (Lane 1) or transiently transfected (Lane 2) with the VRK1 gene. 400 μL Log in to see 10 to 11 Days
$324.50
Details
Human Mouse Un-conjugated WB VRK1 Antibody (Center) (ABIN1882291) western blot analysis in Hela,HL-60 cell line lysates (35 µg/lane). This demonstrates the VRK1 antibody detected the VRK1 protein (arrow). 100 μL Log in to see 10 to 11 Days
$324.50
Details
Human Rabbit Un-conjugated WB Western blot analysis of VRK1 expression in rat thymus extract (lane 1) and JURKAT whole cell lysates (lane 2). VRK1 at 55KD was detected using rabbit anti- VRK1 Antigen Affinity purified polyclonal antibody at0.5 μg/mL. The blot was developed using chemiluminescence (ECL) method 100 μg Log in to see 4 to 6 Days
$240.00
Details
Human Mouse Un-conjugated IF, IP, IHC, ELISA, WB 100 μg Log in to see 7 to 8 Days
$418.00
Details
Human Rabbit APC ELISA, WB   200 μL Log in to see 8 to 10 Days
$969.83
Details
Human Mouse Un-conjugated WB   100 μL Log in to see 8 to 10 Days
$493.17
Details
Human Rabbit Un-conjugated ICC, IHC (fro), IHC (p), ELISA, WB 100 μg Log in to see 9 to 11 Days
$385.00
Details
Human Rabbit Un-conjugated IP, WB VRK1 MaxPab rabbit polyclonal antibody. Western Blot analysis of VRK1 expression in Hela S3 NE. Immunoprecipitation of VRK1 transfected lysate using anti-VRK1 MaxPab rabbit polyclonal antibody and Protein A Magnetic Bead , and immunoblotted with VRK1 purified MaxPab mouse polyclonal antibody (B01P) . 100 μL Log in to see 9 Days
$418.57
Details
Human Mouse Un-conjugated IF, IP, RNAi, ELISA, WB Western blot analysis of VRK1 over-expressed 293 cell line, cotransfected with VRK1 Validated Chimera RNAi (Lane 2) or non-transfected control (Lane 1). Blot probed with VRK1 monoclonal antibody (M02) clone 4F9. GAPDH ( 36.1 kDa ) used as specificity and loading control. Detection limit for recombinant GST tagged VRK1 is approximately 0.1ng/ml as a capture antibody. 100 μg Log in to see 9 Days
$430.00
Details

VRK1 Antibodies by Reactivity, Application, Clonality and Conjugate

Attributes Applications Host Clonality Conjugate
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Top referenced anti-Vaccinia Related Kinase 1 Antibodies

  1. Human Monoclonal VRK1 Primary Antibody for WB - ABIN1882291 : Barcia, López-Borges, Vega, Lazo: Kinetic properties of p53 phosphorylation by the human vaccinia-related kinase 1. in Archives of biochemistry and biophysics 2002 (PubMed)
    Show all 5 references for ABIN1882291

  2. Human Polyclonal VRK1 Primary Antibody for EIA, WB - ABIN359566 : Nezu, Oku, Jones, Shimane: Identification of two novel human putative serine/threonine kinases, VRK1 and VRK2, with structural similarity to vaccinia virus B1R kinase. in Genomics 1998 (PubMed)

More Antibodies against Vaccinia Related Kinase 1 Interaction Partners

Caenorhabditis elegans (C. elegans) Vaccinia Related Kinase 1 (VRK1) interaction partners

  1. vrk-1 has a role in early uterine development in Caenorhabditis elegans

  2. By coordinating VRK-1- and PP2A-mediated signaling on BAF, Lem4 and LEM-4L (Y55F3BR.8) controls postmitotic nuclear envelope formation in a function conserved from worms to humans.

  3. Genome-wide analysis of germ cell proliferation in C. elegans identifies vrk-1 as a key regulator of cep-1/p53 (show TP53 Antibodies).

  4. Data show that expression of the fibroblast growth factor-like protein EGL-17 and its receptor EGL-15 is reduced in vrk-1 mutants, suggesting that VRK-1 might act at least partially through activation of FGF signaling.

Human Vaccinia Related Kinase 1 (VRK1) interaction partners

  1. VRK1 may act as a tumor promoter by controlling the level of cell cycle regulators associated with G1/S transition and could potentially serve as a therapeutic target and/or prognostic biomarker for HCC (show FAM126A Antibodies).

  2. VRK1 is a novel regulator of CBs (show CBS Antibodies) dynamics and stability in cell cycle by protecting coilin (show COIL Antibodies) from ubiquitination and degradation in the proteasome, and propose a model of CB dynamics.

  3. VRK1 regulation of NBS1 (show NBN Antibodies) contributes to the stability of the repair complex and permits the sequential steps in DNA damage response.

  4. VRK1 is a novel chromatin component that reacts to its alterations and participates very early in DNA damage response, functioning by itself or in cooperation with Ataxia Telangiectasia Mutated (show ATM Antibodies) Proteins.

  5. VRK1 deficiency in human and mouse leads to downregulation of amyloid-beta precursor protein (APP (show APP Antibodies)). APP (show APP Antibodies) overexpression rescues the phenotype caused by Vrk1 knockdown, suggesting that VRK1 affects neuronal migration through an APP (show APP Antibodies)-dependent mechanism.

  6. VRK1 can contribute to make these tumors more resistant to DNA damage-based therapies, such as ionizing radiation or doxorubicin, which is consistent with its association to a poor prognosis in ER positive breast cancer.

  7. VRK1 deficiency disrupts nuclear envelope morphology and leads to BAF (show BANF1 Antibodies) retention on mitotic chromosomes.

  8. The VRK1-p53 (show TP53 Antibodies) basal complex is an early-warning system for immediate cellular responses to DNA damage.

  9. This study identification of disease-causing alleles in 3 children from 2 unrelated families with Mutations in VRK1 associated with complex motor and sensory axonal neuropathy plus microcephaly.

  10. Data from molecular dynamic simulations suggest that bivalent cations play key structural roles in stabilization of VRK1/VRK2; bivalent cations have no obvious effects on VRK3. These kinases are targets in search for antineoplastic agents. [REVIEW]

Mouse (Murine) Vaccinia Related Kinase 1 (VRK1) interaction partners

  1. VRK1 deficiency in human and mouse leads to downregulation of amyloid-beta precursor protein (APP (show APP Antibodies)). APP (show APP Antibodies) overexpression rescues the phenotype caused by Vrk1 knockdown, suggesting that VRK1 affects neuronal migration through an APP (show APP Antibodies)-dependent mechanism.

  2. Data suggest that VRK1 is required for both follicle development and oocyte growth in mammalian female reproduction system.

  3. Protein kinase (show CDK7 Antibodies) Cdelta regulates phosphorylation and down-regulation of Vaccinia-related kinase 1 (VRK1), thereby contributing to cell cycle arrest and apoptotic cell death in a p53 (show TP53 Antibodies)-dependent manner.

  4. reduction of VRK1 activity causes a delay in meiotic progression during oogenesis

  5. VRK1 is required for the proliferation and differentiation of undifferentiated spermatogonia, which are essential for spermatogenic cell maintenance

  6. Depletion of VRK1 leads to progressive male infertility as a result of a cessation of spermatogonial proliferation.

  7. These findings collectively support a role of VRK1 as a novel mitotic histone H3 (show HIST3H3 Antibodies) kinase in mammals.

Vaccinia Related Kinase 1 (VRK1) Antigen Profile

Protein Summary

This gene encodes a member of the vaccinia-related kinase (VRK) family of serine/threonine protein kinases. This gene is widely expressed in human tissues and has increased expression in actively dividing cells, such as those in testis, thymus, fetal liver, and carcinomas. Its protein localizes to the nucleus and has been shown to promote the stability and nuclear accumulation of a transcriptionally active p53 molecule and, in vitro, to phosphorylate Thr18 of p53 and reduce p53 ubiquitination. This gene, therefore, may regulate cell proliferation. This protein also phosphorylates histone, casein, and the transcription factors ATF2 (activating transcription factor 2) and c-JUN.

Gene names and symbols associated with VRK1

  • vaccinia related kinase 1 (vrk1) antibody
  • vaccinia related kinase 1 (VRK1) antibody
  • vaccinia related kinase 1 (LOC100340357) antibody
  • Protein VRK-1 (vrk-1) antibody
  • vaccinia related kinase 1 (Vrk1) antibody
  • 51PK antibody
  • MGC64390 antibody
  • MGC75762 antibody
  • PCH1 antibody
  • PCH1A antibody
  • VRK1 antibody
  • wu:fe16f06 antibody
  • zgc:56266 antibody

Protein level used designations for VRK1

vaccinia related kinase 1 , serine/threonine-protein kinase VRK1 , serine/threonine-protein kinase VRK1-like , vaccinia virus B1R-related kinase 1 , vaccinia-related kinase 1 , serine/threonine-protein kinase 51PK

GENE ID SPECIES
380541 Xenopus laevis
394552 Xenopus (Silurana) tropicalis
423443 Gallus gallus
453148 Pan troglodytes
490848 Canis lupus familiaris
704798 Macaca mulatta
100195811 Salmo salar
100401786 Callithrix jacchus
100340357 Oryctolagus cuniculus
174004 Caenorhabditis elegans
7443 Homo sapiens
22367 Mus musculus
362779 Rattus norvegicus
618880 Bos taurus
100157930 Sus scrofa
406694 Danio rerio
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