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Vinculin is a cytoskeletal protein associated with cell-cell and cell-matrix junctions, where it is thought to function as one of several interacting proteins involved in anchoring F-actin to the membrane. Additionally we are shipping Vinculin Kits (42) and Vinculin Proteins (13) and many more products for this protein.
Showing 10 out of 187 products:
Human Monoclonal Vinculin Primary Antibody for IF, WB - ABIN395447
Jugessur, Shi, Gjessing, Lie, Wilcox, Weinberg, Christensen, Boyles, Daack-Hirsch, Nguyen, Christiansen, Lidral, Murray: Maternal genes and facial clefts in offspring: a comprehensive search for genetic associations in two population-based cleft studies from Scandinavia. in PLoS ONE 2010
Show all 5 references for ABIN395447
Human Polyclonal Vinculin Primary Antibody for EIA, WB - ABIN359587
Moiseyeva, Weller, Zhidkova, Corben, Patel, Jasinska, Koteliansky, Critchley: Organization of the human gene encoding the cytoskeletal protein vinculin and the sequence of the vinculin promoter. in The Journal of biological chemistry 1993
Show all 3 references for ABIN359587
Human Polyclonal Vinculin Primary Antibody for EIA, WB - ABIN359586
Izard, Evans, Borgon, Rush, Bricogne, Bois: Vinculin activation by talin through helical bundle conversion. in Nature 2004
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Human Polyclonal Vinculin Primary Antibody for WB - ABIN611567
Hou, Schindler, Henzel, Ho, Brasseur, McKnight: An interleukin-4-induced transcription factor: IL-4 Stat. in Science (New York, N.Y.) 1994
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Chicken Monoclonal Vinculin Primary Antibody for IHC (fro), IF - ABIN1109491
Weller, Ogryzko, Corben, Zhidkova, Patel, Price, Spurr, Koteliansky, Critchley: Complete sequence of human vinculin and assignment of the gene to chromosome 10. in Proceedings of the National Academy of Sciences of the United States of America 1990
Show all 2 references for ABIN1109491
Chicken Monoclonal Vinculin Primary Antibody for FACS, IHC (fro) - ABIN118973
Asijee, Sturk, Bruin, Wilkinson, Ten Cate: Vinculin is a permanent component of the membrane skeleton and is incorporated into the (re)organising cytoskeleton upon platelet activation. in European journal of biochemistry / FEBS 1990
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The VCL-encoding protein was involved in cardiomyopathy that associated with hypertension, therefore our results suggest the rs4746172 of VCL may be a novel target for clinical interventions to reduce CVD risk by regulating blood pressure in male Chinese
Three novel genes were identified as recurrently mutated; MYCN (show MYCN Antibodies), MYO5B and VCL, and mutations in these genes were exclusively found in malignant sympathetic paraganglioma tumors.
roles and mechanisms of phospholipids in regulating the structure and function of vinculin and of its muscle-specific (show EIF3K Antibodies) metavinculin splice variant.
Upon actin engagement, the N-terminal "strap" and helix 1 are displaced from the vinculin tail helical bundle to mediate actin bundling.
This study defined a plastic relationship between vinculin-mediated tension and adhesion complex area that controls fundamental cell-matrix adhesion properties.
Analysis showed that ITGB4 (show ITGB4 Antibodies) and VCL were upregulated in exosomes derived from taxane-resistant prostate cancer cells suggesting them as useful markers for progression of prostate cancer associated with taxane-resistance.
vinculin, present in the joints of anti-citrullinated protein antibody (ACPA (show PRTN3 Antibodies))(+) rheumatoid arthritis patients, was identified as an autoantigen targeted by ACPA (show PRTN3 Antibodies) and CD4 (show CD4 Antibodies)(+) T cells.
The activation of vinculin by stretched talin induces a positive feedback that reinforces the actin-talin-vinculin association.
Data indicate that specific protein interactions are spatially segregated within focal adhesions (FAs (show FAS Antibodies)) at the nanoscale to regulate vinculin activation and function.
Vinculin expression was found to be significantly downregulated.
Binding of vinculin to the R1-R3 region of the talin rod is important for focal adhesion stability.
These data demonstrate that Src-mediated phosphorylation is necessary for vinculin activation, and that phosphorylation controls cytoskeletal mechanics by regulating force transmission between the actin cytoskeleton and focal adhesion proteins.
results suggest that vinculin promotes directionally persistent cell migration and tension-dependent ECM (show MMRN1 Antibodies) remodeling in complex 3D environments by increasing cell-ECM (show MMRN1 Antibodies) adhesion and traction force generation.
Force-dependent conformational switch of alpha-catenin (show CTNNA1 Antibodies) controls vinculin binding.
Mutant vinculin expressing cells are altered in cell migration, which is accompanied by changes in cell adhesion.
show that Src (show SRC Antibodies) phosphorylation of Y1065 within the C-terminal hairpin regulates Vt-mediated actin bundling and provide a detailed characterization of vinculin Y1065 mutations
The E29R mutation might prime the vinculin head for F-actin binding, which results in higher cell stiffness, contractile force, and strengthening of focal adhesions.
Vcl plays a crucial role in stabilizing gap junctions and myocyte integrity through direct interactions with ZO-1 (show TJP1 Antibodies) and stabilization of CX43 (show GJA1 Antibodies).
serine phosphorylation is required for the activation of vinculin and force transmission in focal adhesions.
VCL binding talin, but not Arp2 (show AICDA Antibodies)/3, is critical for osteoclast function, and its selective inhibition retards physiological bone loss.
Results suggest that myosin VI (show MYO6 Antibodies) and vinculin form a molecular apparatus that generates cohesive cell-cell contacts in cultured mammalian epithelia.
Vinculin is a cytoskeletal protein associated with cell-cell and cell-matrix junctions, where it is thought to function as one of several interacting proteins involved in anchoring F-actin to the membrane. Defects in VCL are the cause of cardiomyopathy dilated type 1W. Dilated cardiomyopathy is a disorder characterized by ventricular dilation and impaired systolic function, resulting in congestive heart failure and arrhythmia. Multiple alternatively spliced transcript variants have been found for this gene, but the biological validity of some variants has not been determined.
, vinculin at 2EF