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anti-Vinculin (VCL) Antibodies

Vinculin is a cytoskeletal protein associated with cell-cell and cell-matrix junctions, where it is thought to function as one of several interacting proteins involved in anchoring F-actin to the membrane. Additionally we are shipping Vinculin Kits (42) and Vinculin Proteins (13) and many more products for this protein.

list all antibodies Gene Name GeneID UniProt
VCL 7414 P18206
VCL 22330 Q64727
VCL 305679 P85972
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Top anti-Vinculin Antibodies at antibodies-online.com

Showing 10 out of 187 products:

Catalog No. Reactivity Host Conjugate Application Images Quantity Supplier Delivery Price Details
Human Rabbit Un-conjugated IHC (p), WB Western blot analysis of anti-VINC Antibody (N-term) (ABIN391625) in K562 cell line lysates (35 µg/lane). VINC (arrow) was detected using the purified polyclonal antibody. Western blot analysis of anti-VINC Antibody (N-term) (ABIN391625) in mouse lung tissue lysates (35 µg/lane). VINC (arrow) was detected using the purified polyclonal antibody. 400 μL Log in to see 10 to 11 Days
$324.50
Details
Human Rabbit Un-conjugated WB Western blot analysis of anti-VINC Antibody (C-term) (ABIN391626) in Ramos cell line lysates (35 µg/lane). VINC (arrow) was detected using the purified polyclonal antibody. Western blot analysis of anti-VINC Antibody (C-term) (ABIN391626) in mouse lung tissue lysates (35 µg/lane). VINC (arrow) was detected using the purified polyclonal antibody. 400 μL Log in to see 10 to 11 Days
$324.50
Details
Human Rabbit Un-conjugated EIA, WB Formalin-fixed and paraffin-embedded human skeletal muscle tissue reacted with VINC antibody (N-term) , which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated. (LEFT) Western blot analysis of anti-VINC Antibody (N-term) in K562 cell line lysates (35ug/lane). VINC (arrow) was detected using the purified Pab. (RIGHT) Western blot analysis of anti-VINC Antibody (N-term) in mouse lung tissue lysates (35ug/lane). VINC (arrow) was detected using the purified Pab. 0.4 mL Log in to see 6 to 8 Days
$390.50
Details
Human Rabbit Un-conjugated EIA, WB (LEFT) Western blot analysis of anti-VINC Antibody (C-term) in Ramos cell line lysates (35ug/lane). VINC (arrow) was detected using the purified Pab. (RIGHT) Western blot analysis of anti-VINC Antibody (C-term) in mouse lung tissue lysates (35ug/lane). VINC (arrow) was detected using the purified Pab. 0.4 mL Log in to see 6 to 8 Days
$390.50
Details
Chicken Mouse Un-conjugated FACS, IHC (fro), IHC (p), IP, WB Vinculin - ABIN118973 - Human appendix. Formalin fixed, paraffin processed tissue. 2 mL Log in to see 6 to 8 Days
$456.50
Details
Chicken Mouse Un-conjugated IHC (fro), IF, WB   0.1 mg Log in to see 6 to 8 Days
$313.50
Details
Human Rabbit Un-conjugated IF, IHC (p), WB 0.1 mg Log in to see 6 to 8 Days
$390.50
Details
Human Mouse Un-conjugated IF, WB Immunofluorescence of monoclonal antibody to VCL on HeLa cell (antibody concentration 10 µg/mL). VCL monoclonal antibody (M01), clone 2C6-1B5 Western Blot analysis of VCL expression in Hela. 0.1 mg Log in to see 8 to 11 Days
$450.00
Details
Human Rabbit Un-conjugated WB 50 μg Log in to see 8 to 10 Days
$551.83
Details
Human Rabbit Un-conjugated IHC (p) 1 mL Log in to see 6 to 8 Days
$797.50
Details

VCL Antibodies by Reactivity, Application, Clonality and Conjugate

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Top referenced anti-Vinculin Antibodies

  1. Human Monoclonal Vinculin Primary Antibody for IF, WB - ABIN395447 : Jugessur, Shi, Gjessing, Lie, Wilcox, Weinberg, Christensen, Boyles, Daack-Hirsch, Nguyen, Christiansen, Lidral, Murray: Maternal genes and facial clefts in offspring: a comprehensive search for genetic associations in two population-based cleft studies from Scandinavia. in PLoS ONE 2010 (PubMed)
    Show all 5 references for ABIN395447

  2. Human Polyclonal Vinculin Primary Antibody for EIA, WB - ABIN359587 : Moiseyeva, Weller, Zhidkova, Corben, Patel, Jasinska, Koteliansky, Critchley: Organization of the human gene encoding the cytoskeletal protein vinculin and the sequence of the vinculin promoter. in The Journal of biological chemistry 1993 (PubMed)
    Show all 3 references for ABIN359587

  3. Human Polyclonal Vinculin Primary Antibody for EIA, WB - ABIN359586 : Izard, Evans, Borgon, Rush, Bricogne, Bois: Vinculin activation by talin through helical bundle conversion. in Nature 2004 (PubMed)
    Show all 3 references for ABIN359586

  4. Human Polyclonal Vinculin Primary Antibody for WB - ABIN611567 : Hou, Schindler, Henzel, Ho, Brasseur, McKnight: An interleukin-4-induced transcription factor: IL-4 Stat. in Science (New York, N.Y.) 1994 (PubMed)
    Show all 3 references for ABIN611567

  5. Chicken Monoclonal Vinculin Primary Antibody for IHC (fro), IF - ABIN1109491 : Weller, Ogryzko, Corben, Zhidkova, Patel, Price, Spurr, Koteliansky, Critchley: Complete sequence of human vinculin and assignment of the gene to chromosome 10. in Proceedings of the National Academy of Sciences of the United States of America 1990 (PubMed)
    Show all 2 references for ABIN1109491

  6. Chicken Monoclonal Vinculin Primary Antibody for FACS, IHC (fro) - ABIN118973 : Asijee, Sturk, Bruin, Wilkinson, Ten Cate: Vinculin is a permanent component of the membrane skeleton and is incorporated into the (re)organising cytoskeleton upon platelet activation. in European journal of biochemistry / FEBS 1990 (PubMed)
    Show all 2 references for ABIN118973

More Antibodies against Vinculin Interaction Partners

Human Vinculin (VCL) interaction partners

  1. The VCL-encoding protein was involved in cardiomyopathy that associated with hypertension, therefore our results suggest the rs4746172 of VCL may be a novel target for clinical interventions to reduce CVD risk by regulating blood pressure in male Chinese

  2. Three novel genes were identified as recurrently mutated; MYCN (show MYCN Antibodies), MYO5B and VCL, and mutations in these genes were exclusively found in malignant sympathetic paraganglioma tumors.

  3. roles and mechanisms of phospholipids in regulating the structure and function of vinculin and of its muscle-specific (show EIF3K Antibodies) metavinculin splice variant.

  4. Upon actin engagement, the N-terminal "strap" and helix 1 are displaced from the vinculin tail helical bundle to mediate actin bundling.

  5. This study defined a plastic relationship between vinculin-mediated tension and adhesion complex area that controls fundamental cell-matrix adhesion properties.

  6. Analysis showed that ITGB4 (show ITGB4 Antibodies) and VCL were upregulated in exosomes derived from taxane-resistant prostate cancer cells suggesting them as useful markers for progression of prostate cancer associated with taxane-resistance.

  7. vinculin, present in the joints of anti-citrullinated protein antibody (ACPA (show PRTN3 Antibodies))(+) rheumatoid arthritis patients, was identified as an autoantigen targeted by ACPA (show PRTN3 Antibodies) and CD4 (show CD4 Antibodies)(+) T cells.

  8. The activation of vinculin by stretched talin induces a positive feedback that reinforces the actin-talin-vinculin association.

  9. Data indicate that specific protein interactions are spatially segregated within focal adhesions (FAs (show FAS Antibodies)) at the nanoscale to regulate vinculin activation and function.

  10. Vinculin expression was found to be significantly downregulated.

Mouse (Murine) Vinculin (VCL) interaction partners

  1. Binding of vinculin to the R1-R3 region of the talin rod is important for focal adhesion stability.

  2. These data demonstrate that Src-mediated phosphorylation is necessary for vinculin activation, and that phosphorylation controls cytoskeletal mechanics by regulating force transmission between the actin cytoskeleton and focal adhesion proteins.

  3. results suggest that vinculin promotes directionally persistent cell migration and tension-dependent ECM (show MMRN1 Antibodies) remodeling in complex 3D environments by increasing cell-ECM (show MMRN1 Antibodies) adhesion and traction force generation.

  4. Force-dependent conformational switch of alpha-catenin (show CTNNA1 Antibodies) controls vinculin binding.

  5. Mutant vinculin expressing cells are altered in cell migration, which is accompanied by changes in cell adhesion.

  6. show that Src (show SRC Antibodies) phosphorylation of Y1065 within the C-terminal hairpin regulates Vt-mediated actin bundling and provide a detailed characterization of vinculin Y1065 mutations

  7. The E29R mutation might prime the vinculin head for F-actin binding, which results in higher cell stiffness, contractile force, and strengthening of focal adhesions.

  8. Vcl plays a crucial role in stabilizing gap junctions and myocyte integrity through direct interactions with ZO-1 (show TJP1 Antibodies) and stabilization of CX43 (show GJA1 Antibodies).

  9. serine phosphorylation is required for the activation of vinculin and force transmission in focal adhesions.

  10. VCL binding talin, but not Arp2 (show AICDA Antibodies)/3, is critical for osteoclast function, and its selective inhibition retards physiological bone loss.

Pig (Porcine) Vinculin (VCL) interaction partners

  1. Results suggest that myosin VI (show MYO6 Antibodies) and vinculin form a molecular apparatus that generates cohesive cell-cell contacts in cultured mammalian epithelia.

Vinculin (VCL) Antigen Profile

Protein Summary

Vinculin is a cytoskeletal protein associated with cell-cell and cell-matrix junctions, where it is thought to function as one of several interacting proteins involved in anchoring F-actin to the membrane. Defects in VCL are the cause of cardiomyopathy dilated type 1W. Dilated cardiomyopathy is a disorder characterized by ventricular dilation and impaired systolic function, resulting in congestive heart failure and arrhythmia. Multiple alternatively spliced transcript variants have been found for this gene, but the biological validity of some variants has not been determined.

Gene names and symbols associated with anti-Vinculin (VCL) Antibodies

  • vinculin (VCL) antibody
  • vinculin (vcl) antibody
  • vinculin A (vinA) antibody
  • Vinculin (Vinc) antibody
  • vinculin (CpipJ_CPIJ013873) antibody
  • vinculin (LOC100228062) antibody
  • vinculin (LOC100356093) antibody
  • vinculin (Vcl) antibody
  • vinculin (Bm1_37935) antibody
  • 9430097D22 antibody
  • AA571387 antibody
  • AI462105 antibody
  • AW545629 antibody
  • CG3299 antibody
  • CMD1W antibody
  • CMH15 antibody
  • CT11081 antibody
  • DDBDRAFT_0186762 antibody
  • DDBDRAFT_0232320 antibody
  • DDB_0186762 antibody
  • DDB_0232320 antibody
  • Dmel\\CG3299 antibody
  • Dmvincp antibody
  • EG:103B4.1 antibody
  • hm:zehn2160 antibody
  • im:6902790 antibody
  • LOC100228062 antibody
  • MV antibody
  • MVCL antibody
  • VCL antibody
  • vcl-A antibody
  • Vin antibody
  • Vin2EF antibody
  • vinc antibody

Protein level used designations for anti-Vinculin (VCL) Antibodies

vinculin , CG3299-PA , Vinc-PA , vinculin at 2EF , vinculin-like , metavinculin , vinculin/metavinculin

GENE ID SPECIES
100064165 Equus caballus
450531 Pan troglodytes
552980 Danio rerio
8625369 Dictyostelium discoideum AX4
31201 Drosophila melanogaster
6047004 Culex quinquefasciatus
100036705 Xenopus (Silurana) tropicalis
100228062 Taeniopygia guttata
100410985 Callithrix jacchus
100476722 Ailuropoda melanoleuca
714312 Macaca mulatta
721921 Macaca mulatta
100075715 Ornithorhynchus anatinus
100583187 Nomascus leucogenys
7414 Homo sapiens
396422 Gallus gallus
100356093 Oryctolagus cuniculus
22330 Mus musculus
305679 Rattus norvegicus
783645 Bos taurus
373770 Xenopus laevis
100302597 Meleagris gallopavo
479252 Canis lupus familiaris
100357160 Oryctolagus cuniculus
396974 Sus scrofa
100722183 Cavia porcellus
101121312 Ovis aries
6102471 Brugia malayi
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