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VDAC1 encodes a voltage-dependent anion channel protein that is a major component of the outer mitochondrial membrane. Additionally we are shipping VDAC1 Kits (6) and VDAC1 Proteins (5) and many more products for this protein.
Showing 10 out of 149 products:
Arabidopsis thaliana Polyclonal VDAC1 Primary Antibody for BN PAGE, IL - ABIN3155731
Ito, Batth, Petzold, Redding-Johanson, Mukhopadhyay, Verboom, Meyer, Millar, Heazlewood: Analysis of the Arabidopsis Cytosolic Proteome Highlights Subcellular Partitioning of Central Plant Metabolism. in Journal of proteome research 2010
Show all 10 references for ABIN3155731
Bird (Avian) Polyclonal VDAC1 Primary Antibody for EIA, WB - ABIN401311
Liu, Brouha, Grossman: Rapid induction of mitochondrial events and caspase-independent apoptosis in Survivin-targeted melanoma cells. in Oncogene 2004
Show all 7 references for ABIN401311
Cow (Bovine) Polyclonal VDAC1 Primary Antibody for IHC, WB - ABIN2776153
Zheng, Shi, Tian, Jiang, Jin, Chen, Almasan, Tang, Chen: Essential role of the voltage-dependent anion channel (VDAC) in mitochondrial permeability transition pore opening and cytochrome c release induced by arsenic trioxide. in Oncogene 2004
Show all 4 references for ABIN2776153
Human Polyclonal VDAC1 Primary Antibody for FACS, IHC (p) - ABIN390563
Shoshan-Barmatz, Zakar, Rosenthal, Abu-Hamad: Key regions of VDAC1 functioning in apoptosis induction and regulation by hexokinase. in Biochimica et biophysica acta 2009
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Human Polyclonal VDAC1 Primary Antibody for IF (p), IHC (p) - ABIN686872
Manczak, Reddy: Abnormal interaction of VDAC1 with amyloid beta and phosphorylated tau causes mitochondrial dysfunction in Alzheimer's disease. in Human molecular genetics 2012
Show all 2 references for ABIN686872
Human Polyclonal VDAC1 Primary Antibody for EIA, WB - ABIN453456
Hiller, Garces, Malia, Orekhov, Colombini, Wagner: Solution structure of the integral human membrane protein VDAC-1 in detergent micelles. in Science (New York, N.Y.) 2008
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Cow (Bovine) Polyclonal VDAC1 Primary Antibody for IHC, WB - ABIN223288
Bortner, Scoltock, Sifre, Cidlowski: Osmotic stress resistance imparts acquired anti-apoptotic mechanisms in lymphocytes. in The Journal of biological chemistry 2012
Show all 2 references for ABIN223288
Human Polyclonal VDAC1 Primary Antibody for ELISA, WB - ABIN1043886
Bourekas, Slivka, Shah, Sunshine, Suarez: Intraarterial thrombolytic therapy within 3 hours of the onset of stroke. in Neurosurgery 2003
Abnormal ovules in the process of female gametogenesis were observed. Both mitochondrial transmembrane potential and ATP synthesis rate were obviously reduced in the mitochondria isolated from atvdac1 plants.
Data indicate that both voltage-dependent anion channel 1 (AtVDAC1) and calcium sensor CBL1 regulate cold stress responses during seed germination and plant development.
AtVDAC1 has a main function in mitochondria
VDAC1 is not only necessary for normal growth but also important for disease resistance through regulation of hydrogen peroxide generation.
Results shows that beta-barrel of human VDAC1 embedded into a membrane is highly flexible and that Ca2+, a key regulator of metabolism and apoptosis, strongly decreases its plasticity suggesting that physiological VDAC function depends on the molecular plasticity of its channel.
High VDAC1 expression is associated with cervical cancer.
Studies using B16F10 and A375 cells genetically modified for ATF2 (show ATF2 Antibodies) indicated that mitochondrial ATF2 (show ATF2 Antibodies) was able to dissociate Bim (show BCL2L11 Antibodies) from the Mcl-1 (show MCL1 Antibodies)/Bim (show BCL2L11 Antibodies) complex to trigger VDAC1 oligomerization.
findings also suggest that VDAC1 may be a novel biomarker for gastric cancer
serum starvation induces CREB1 (show CREB1 Antibodies) expression, in turn activating miR (show MLXIP Antibodies)-320a expression, which then down-regulates VDAC1 expression to facilitate mitophagy
Reducing VDAC1 expression induces a non-apoptotic role for pro-apoptotic proteins in glioblastoma multiforme cancer cell differentiation.
The works available on VDAC cysteines support the notion that VDAC1, VDAC2 (show VDAC2 Antibodies), and VDAC3 (show VDAC3 Antibodies) proteins are paralogs with a similar pore-function and slightly different, but important, ancillary biological functions. (Review)
The protective effect of miR-7 (show LILRB1 Antibodies) is partly exerted through promoting mitochondrial function by targeting VDAC1 expression.
Data show that voltage-dependent anion channel 1 (VDAC1) knockout cells are resistant to AMP-activated protein kinase (AMPK (show PRKAA2 Antibodies)) and mechanistic target of rapamycin (mTOR (show FRAP1 Antibodies)) modulation by itraconazole, indicating VDAC1 is the mediator of the activity.
Amyloid beta -mediated toxicity involves mitochondrial and plasma membrane VDAC1, leading to mitochondrial dysfunction and apoptosis induction.
Data confirm the synthesis of VDAC1 and 2 subtypes in GV (germinal vesicle) and MII (meiosis II) stage porcine oocytes as well as their protein expression.
Results describe the expression of voltage-dependent anion channel isoforms in rat, bovine, and chicken brain mitochondria, and suggest that the nature of hexokinase binding site is not determined by the expression of a single VDAC isoform.
Suggest that VDAC1 participates in volume regulatory processes in spermatozoa.
VDAC1-interacting anion transport inhibitors inhibited apoptosis via direct interaction with VDAC1 to inhibit its oligomerization and subsequent Cyto c release and apoptosis.
TSPO (show TSPO Antibodies) as a novel element in the regulation of mitochondrial quality control by autophagy, and demonstrate the importance for cell homeostasis of its expression ratio with voltage-dependent anion channel 1
ATP flows through VDAC through multiple pathways, in agreement with our structural data and experimentally determined physiological rates.
Reduced VDAC1 expression protects against Alzheimer's disease and synaptic deficiencies.
Data suggest presence of unstructured C-terminal tubulin (show TUBB Antibodies) tail in VDAC pore decreases conductance and switches selectivity from anionic to cationic rendering ATP transport virtually impossible; involves stable salt bridge (K336-tubulin (show TUBB Antibodies)/D186-Vdac1).
MAVS (show MAVS Antibodies) binds to voltage-dependent anion channel 1 (VDAC1) and induces apoptosis by caspase-3 (show CASP3 Antibodies) activation, which is independent of its role in innate immunity.
Abnormal interaction of VDAC1 with amyloid beta and phosphorylated tau causes mitochondrial dysfunction in Alzheimer's disease.
Flexibility of the N-terminal mVDAC1 segment controls the channel's gating behavior.
the N-terminal alpha-helix is located inside the pore of VDAC in the open state and remains associated with beta-strand 11 of the pore wall during voltage gating
we found that Bcl-wav controls intracellular Ca(2+) trafficking by acting on the mitochondrial voltage-dependent anion channel, and possibly on MCU, with direct consequences on actin microfilament dynamics and blastomere migration guidance.
This gene encodes a voltage-dependent anion channel protein that is a major component of the outer mitochondrial membrane. The encoded protein facilitates the exchange of metabolites and ions across the outer mitochondrial membrane and may regulate mitochondrial functions. This protein also forms channels in the plasma membrane and may be involved in transmembrane electron transport. Alternate splicing results in multiple transcript variants. Multiple pseudogenes of this gene are found on chromosomes 1, 2 3, 6, 9, 12, X and Y.
voltage-dependent anion channel 1
, outer mitochondrial membrane protein porin 1
, plasmalemmal porin
, porin 31HL
, porin 31HM
, voltage-dependent anion-selective channel protein 1
, brain-derived voltage-dependent anion channel 1
, voltage-dependent anion-selective channel protein 5