VDAC1 antibody (Voltage-Dependent Anion Channel 1) (AA 1-30)

Details for Product anti-VDAC1 Antibody No. ABIN390563, Supplier: Log in to see
Antigen
  • vdac1
  • VDAC1
  • 5076
  • ARABIDOPSIS THALIANA VOLTAGE DEPENDENT ANION CHANNEL 1
  • ATVDAC1
  • T22N4.9
  • T22N4_9
  • voltage dependent anion channel 1
  • PORIN
  • VDAC-1
  • AL033343
  • Vdac5
  • fa13f11
  • wu:fa13f11
  • zgc:85830
  • voltage-dependent anion channel 1
  • voltage dependent anion channel 1
  • vdac1
  • VDAC1
  • Vdac1
Epitope
AA 1-30, N-Term
49
23
16
12
10
6
6
4
3
3
2
2
2
2
2
2
1
1
1
1
1
1
Reactivity
Human, Mouse (Murine)
184
89
85
11
10
6
4
4
3
3
3
2
2
2
2
2
2
1
1
1
1
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1
Host
Rabbit
126
62
Clonality (Clone)
Polyclonal ()
Conjugate
This VDAC1 antibody is un-conjugated
6
6
5
4
4
4
3
3
3
3
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3
3
3
3
3
2
2
2
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
Application
Flow Cytometry (FACS), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Western Blotting (WB)
173
85
73
59
44
33
11
8
4
3
2
1
1
1
1
1
Options
Supplier
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Immunogen This VDAC1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 1-30 AA from the N-terminal region of human VDAC1.
Clone RB19920
Isotype Ig
Specificity This VDAC1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 1~30 amino acids from the N-terminal region of human VDAC1.
Predicted Reactivity Cow (Bovine),Pig (Porcine),Rat (Rattus),Rabbit
Purification This antibody is purified through a protein A column, followed by peptide affinity purification.
Alternative Name VDAC1 (VDAC1 Antibody Abstract)
Background VDAC1 forms a channel through the mitochondrial outer membrane and also the plasma membrane. The channel at the outer mitochondrial membrane allows diffusion of small hydrophilic molecules, in the plasma membrane it is involved in cell volume regulation and apoptosis. It adopts an open conformation at low or zero membrane potential and a closed conformation at potentials above 30-40 mV. The open state has a weak anion selectivity whereas the closed state is cation-selective. The protein may participate in the formation of the permeability transition pore complex (PTPC) responsible for the release of mitochondrial products that triggers apoptosis.
Synonyms: Voltage-dependent anion-selective channel protein 1, VDAC-1, hVDAC1, Outer mitochondrial membrane protein porin 1, Plasmalemmal porin, Porin 31HL, Porin 31HM, VDAC, VDAC1
Molecular Weight 30773 DA
Gene ID 7416
UniProt P21796
Research Area Apoptosis/Necrosis, Cancer, Cell Structure
Application Notes WB = 1:1000, IHC (p) = 1:50-100, FACS = 1:10-50
Restrictions For Research Use only
Format Liquid
Concentration 0.33 mg/mL
Buffer PBS with 0.09 % (W/V) sodium azide
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage 4 °C/-20 °C
Storage Comment Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C in small aliquots to prevent freeze-thaw cycles.
Expiry Date 6 months
Supplier Images
Western Blotting (WB) image for anti-Voltage-Dependent Anion Channel 1 (VDAC1) (AA 1-30), (N-Term) antibody (ABIN390563) Western blot analysis of VDAC1 Antibody (N-term) (ABIN390563) in A375 cell line and m...
Immunohistochemistry (IHC) image for anti-Voltage-Dependent Anion Channel 1 (VDAC1) (AA 1-30), (N-Term) antibody (ABIN390563) Formalin-fixed and paraffin-embedded human hepatocarcinoma reacted with VDAC1 Antibod...
Western Blotting (WB) image for anti-Voltage-Dependent Anion Channel 1 (VDAC1) (AA 1-30), (N-Term) antibody (ABIN390563) Western blot analysis of VDAC1 (arrow) using rabbit polyclonal VDAC1 Antibody (N-term...
Product cited in: Chu, Goldman, Kelly, He, Waliczek, Kordower: "Abnormal alpha-synuclein reduces nigral voltage-dependent anion channel 1 in sporadic and experimental Parkinson's disease." in: Neurobiology of disease, Vol. 69, pp. 1-14, 2014 (PubMed).

Background publications Shoshan-Barmatz, Zakar, Rosenthal, Abu-Hamad: "Key regions of VDAC1 functioning in apoptosis induction and regulation by hexokinase." in: Biochimica et biophysica acta, Vol. 1787, Issue 5, pp. 421-30, 2009 (PubMed).

Hiller, Garces, Malia, Orekhov, Colombini, Wagner: "Solution structure of the integral human membrane protein VDAC-1 in detergent micelles." in: Science (New York, N.Y.), Vol. 321, Issue 5893, pp. 1206-10, 2008 (PubMed).

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