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WBP2NL is a sperm-specific WW domain-binding protein that promotes meiotic resumption and pronuclear development during oocyte fertilization (Wu et al., 2007 [PubMed 17289678]).[supplied by OMIM, Mar 2008].. Additionally we are shipping WBP2 N-terminal Like Antibodies (33) and WBP2 N-terminal Like Kits (4) and many more products for this protein.
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Data provides evidence for the first time that sperm-anchored PAWP is a primary initiator of zygotic development.
Conclude that human PAWP is neither sufficient nor necessary for the Ca(2 (show CA2 Proteins)+) oscillations that initiate mammalian oocyte activation at fertilization.
WBP2NL might play roles as an anti-apoptotic factor or co-activator to promote breast cancer cell survival and proliferation.
Data suggest that PAWP (WW domain-binding protein 2-like) from sperm (rather than PLCZ (show PLCz1 Proteins) [phospholipase C zeta (show PLCz1 Proteins)] from sperm) acts as the 'sperm factor' within the egg at fertilization and is involved in 'egg activation' and embryogenesis. [REVIEW]
Demonstrate significant correlations between sperm PAWP levels and both fertilization rates and normal embryonic development after intracytoplasmic sperm injection.
PAWP correlates with semen/fertility parameters used in the cattle artificial insemination industry, making PAWP a potential biomarker of bull fertility.
PAWP is a sperm-specific WW domain-binding protein that promotes meiotic resumption and pronuclear development during fertilization
PAWP does not play an essential role in mouse fertilization
The data suggest that sperm-derived PAWP is not involved in triggering Ca(2 (show CA2 Proteins)+) oscillations at fertilization in mammalian oocytes.
These results indicate that PAWP plays a role in spermatogenesis and germ cell development. Moreover, we suggest PAWP as one of the markers that could be looked in ESC studies as a confirmed testis-specific (show AIF1 Proteins) gene
The postacrosomal assembly of sperm head protein, PAWP, is independent of acrosome formation and dependent on microtubular manchette transport
WBP2NL is a sperm-specific WW domain-binding protein that promotes meiotic resumption and pronuclear development during oocyte fertilization (Wu et al., 2007
WBP2 N-terminal like
, WW domain-binding protein 2-like
, postacrosomal sheath WW domain-binding protein