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WBP2NL is a sperm-specific WW domain-binding protein that promotes meiotic resumption and pronuclear development during oocyte fertilization (Wu et al., 2007 [PubMed 17289678]).[supplied by OMIM, Mar 2008].. Additionally we are shipping WBP2 N-terminal Like Antibodies (33) and WBP2 N-terminal Like Kits (5) and many more products for this protein.
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Data provides evidence for the first time that sperm-anchored PAWP is a primary initiator of zygotic development.
In male infertility, the absence of PLCZ1 (show PLCz1 Proteins) alone is sufficient to prevent oocyte activation irrespective of the presence of PAWP.
Conclude that human PAWP is neither sufficient nor necessary for the Ca(2 (show CA2 Proteins)+) oscillations that initiate mammalian oocyte activation at fertilization.
WBP2NL might play roles as an anti-apoptotic factor or co-activator to promote breast cancer cell survival and proliferation.
Data suggest that PAWP (WW domain-binding protein 2-like) from sperm (rather than PLCZ (show PLCz1 Proteins) [phospholipase C zeta (show PLCz1 Proteins)] from sperm) acts as the 'sperm factor' within the egg at fertilization and is involved in 'egg activation' and embryogenesis. [REVIEW]
Demonstrate significant correlations between sperm PAWP levels and both fertilization rates and normal embryonic development after intracytoplasmic sperm injection.
PAWP correlates with semen/fertility parameters used in the cattle artificial insemination industry, making PAWP a potential biomarker of bull fertility.
PAWP is a sperm-specific WW domain-binding protein that promotes meiotic resumption and pronuclear development during fertilization
PAWP does not play an essential role in mouse fertilization
The data suggest that sperm-derived PAWP is not involved in triggering Ca(2 (show CA2 Proteins)+) oscillations at fertilization in mammalian oocytes.
These results indicate that PAWP plays a role in spermatogenesis and germ cell development. Moreover, we suggest PAWP as one of the markers that could be looked in ESC studies as a confirmed testis-specific (show AIF1 Proteins) gene
The postacrosomal assembly of sperm head protein, PAWP, is independent of acrosome formation and dependent on microtubular manchette transport
WBP2NL is a sperm-specific WW domain-binding protein that promotes meiotic resumption and pronuclear development during oocyte fertilization (Wu et al., 2007
WBP2 N-terminal like
, WW domain-binding protein 2-like
, postacrosomal sheath WW domain-binding protein