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The protein encoded by WDHD1 contains multiple N-terminal WD40 domains and a C-terminal high mobility group (HMG) box. Additionally we are shipping WDHD1 Antibodies (34) and many more products for this protein.
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Dna2 co-localizes in foci with RPA (show RPA1 Proteins) and is found in a complex with replication fork components And-1 and Mcm10 (show MCM10 Proteins). Dna2 interacts with the DSB repair and checkpoint proteins Nbs1 (show NLRP2 Proteins) and ATM (show ATM Proteins).
RecQL4 (show RECQL4 Proteins)-dependent association of Mcm10 (show MCM10 Proteins) and Ctf4 with replication origins appears to be the first important step controlled by S phase promoting kinases and checkpoint pathways for the initiation of DNA replication in human cells.
And-1 coordinates with Claspin for efficient Chk1 (show CHEK1 Proteins) activation in response to replication stress.
The Ctf4-CMG complex contains a homodimeric Ctf4 that acts as a platform linking polymerase alpha to the monomeric hCMG complex.
And-1 together with HJURP (show HJURP Proteins) regulates the assembly of new CENP-A (show CENPA Proteins) onto centromeres.
Human And-1 facilitates loading of the MCM2-7 helicase onto chromatin during the assembly of prereplicative complex.
Data show that And-1 forms a complex with both histone H3 and Gcn5.
Mcm10 (show MCM10 Proteins) is required for chromatin loading of And-1.
Assembly of the Cdc45 (show CDC45 Proteins)-Mcm2-7 (show MCM2 Proteins)-GINS complex requires the Ctf4/And-1, RecQL4 (show RECQL4 Proteins), and Mcm10 (show MCM10 Proteins) proteins.
The protein encoded by this gene contains multiple N-terminal WD40 domains and a C-terminal high mobility group (HMG) box. WD40 domains are found in a variety of eukaryotic proteins and may function as adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly. HMG boxes are found in many eukaryotic proteins involved in chromatin assembly, transcription and replication. Alternative splicing results in two transcript variants encoding different isoforms.
WD repeat and HMG-box DNA-binding protein 1
, WD repeat and HMG-box DNA binding protein 1
, WD repeat and HMG-box DNA-binding protein 1-like
, AND-1 protein
, acidic nucleoplasmic DNA-binding protein 1
, Acidic nucleoplasmic DNA-binding protein 1
, CTF4, chromosome transmission fidelity factor 4 homolog