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WNK Lysine Deficient Protein Kinase 2 Proteins (WNK2)

The protein encoded by WNK2 is a cytoplasmic serine-threonine kinase that contains cysteine in place of the lysine found at the conserved ATP-binding location in subdomain II of protein kinases. Additionally we are shipping WNK2 Antibodies (32) and WNK2 Kits (1) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
WNK2 65268 Q9Y3S1
Mouse WNK2 WNK2 75607 Q3UH66
Rat WNK2 WNK2 306811  
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Top WNK2 Proteins at antibodies-online.com

Showing 2 out of 2 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
HOST_Wheat germ Human GST tag 10 μg Log in to see 9 Days
$405.71
Details
HOST_Baculovirus infected Insect Cells Human GST tag   5 μg Log in to see 10 to 12 Days
$322.08
Details

WNK2 Proteins by Origin and Source

Origin Expressed in Conjugate
Human ,

More Proteins for WNK Lysine Deficient Protein Kinase 2 (WNK2) Interaction Partners

Human WNK Lysine Deficient Protein Kinase 2 (WNK2) interaction partners

  1. WNK2 promoter methylation and silencing in gliomas is associated with increased JNK (show MAPK8 Proteins) activation and MMP2 (show MMP2 Proteins) expression and activity, thus explaining in part tumor cell invasion potential.

  2. Downregulation of WNK2 by promoter hypermethylation occurs early in Pancreatic ductal adenocarcinoma pathogenesis and may support tumor cell growth via the ERK-MAPK (show MAPK1 Proteins) pathway.

  3. Wnk kinases are positive regulators of canonical Wnt (show WNT2 Proteins)/beta-catenin (show CTNNB1 Proteins) signaling.

  4. results validate the WNK2 gene as a recurrent target for epigenetic silencing in glia-derived brain tumours and provide first mechanistic evidence for a tumour-suppressing role of WNK2 that is related to Rac1 signalling and tumour cell invasion and growth

  5. a role for WNK2 in the regulation of CCCs in the mammalian brain, with implications for both cell volume regulation and/or GABAergic signaling.

  6. epigenetic silencing, occasional deletion and point mutation, and functional assessment suggest that aberrations of WNK2 may contribute to unregulated tumor cell growth

  7. WNK2 is involved in the modulation of growth factor-induced cancer cell proliferation through the MEK1/ERK1/2 pathway.

  8. WNK2 controls a RhoA-mediated cross-talk mechanism that regulates the efficiency with which MEK1 can activate ERK1/2 upon growth factor stimulation.

  9. Epigenetic silencing of the kinase tumor suppressor WNK2 is tumor-type and tumor-grade specific.

WNK2 Protein Profile

Protein Summary

The protein encoded by this gene is a cytoplasmic serine-threonine kinase that contains cysteine in place of the lysine found at the conserved ATP-binding location in subdomain II of protein kinases. Since this protein does have kinase activity, it is possible that another lysine in the kinase subdomain I can substitute for the missing conserved lysine.

Gene names and symbols associated with WNK2

  • WNK lysine deficient protein kinase 2 (WNK2)
  • serine/threonine-protein kinase WNK2 (WNK2)
  • WNK lysine deficient protein kinase 2 (Wnk2)
  • 1810073P09Rik protein
  • ARABIDOPSIS THALIANA WITH NO K 2 protein
  • ATWNK2 protein
  • AW122246 protein
  • ESTM15 protein
  • mKIAA1760 protein
  • NY-CO-43 protein
  • P/OKcl.13 protein
  • PRKWNK2 protein
  • PROTEIN KINASE protein
  • RGD1307284 protein
  • SDCCAG43 protein
  • with no lysine (K) kinase 2 protein
  • WNK2 protein
  • X83337 protein
  • ZIK3 protein

Protein level used designations for WNK2

WNK lysine deficient protein kinase 2 , antigen NY-CO-43 , mitogen-activated protein kinase kinase kinase , protein kinase lysine-deficient 2 , protein kinase with no lysine 2 , protein kinase, lysine deficient 2 , serine/threonine-protein kinase WNK2 , serologically defined colon cancer antigen 43 , kinase deficient protein

GENE ID SPECIES
415984 Gallus gallus
506520 Bos taurus
717275 Macaca mulatta
100544669 Meleagris gallopavo
821810 Arabidopsis thaliana
65268 Homo sapiens
75607 Mus musculus
306811 Rattus norvegicus
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