anti-WNK Lysine Deficient Protein Kinase 4 (WNK4) Antibodies

WNK4 encodes a member of the WNK family of serine-threonine protein kinases. Additionally we are shipping WNK4 Proteins (6) and many more products for this protein.

list all antibodies Gene Name GeneID UniProt
WNK4 65266 Q96J92
WNK4 69847 Q80UE6
WNK4 287715 Q7TPK6
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Top anti-WNK4 Antibodies at antibodies-online.com

Showing 10 out of 74 products:

Catalog No. Reactivity Host Conjugate Application Images Quantity Supplier Delivery Price Details
Human Rabbit Un-conjugated EM, IHC, IHC (fro), IHC (p), WB Detection of WNK4 in mouse kidney lysate using ABIN153223. Western Blot: WNK4 Antibody [ABIN153223] - Western Blot Image of anti-WNK4. Whole cell protein from Hek293 was separated on a 7.5% gel by SDS-PAGE, transferred to PVDF membrane and blocked in 5% non-fat milk in TBST. The membrane was probed with 2.0 ug/ml anti-WNK4 in 1% milk and detected with an anti-rabbit HRP secondary antibody using chemiluminescence 0.1 mL Log in to see 7 to 9 Days
$408.19
Details
Mouse Rabbit Un-conjugated IHC, ELISA, WB   0.1 mg Log in to see 2 to 6 Days
$327.00
Details
Human Rabbit Alexa Fluor 594 IF (p)   100 μL Log in to see 14 to 21 Days
$405.90
Details
Human Rabbit HRP IHC (p), WB   100 μL Log in to see 14 to 21 Days
$405.90
Details
Human Rabbit Cy3 IF (p)   100 μL Log in to see 14 to 21 Days
$405.90
Details
Human Rabbit Cy5 IF (p)   100 μL Log in to see 14 to 21 Days
$405.90
Details
Human Rabbit Cy5.5 IF (p)   100 μL Log in to see 14 to 21 Days
$405.90
Details
Human Rabbit Cy7 IF (p)   100 μL Log in to see 14 to 21 Days
$405.90
Details
Human Rabbit FITC IF (p)   100 μL Log in to see 14 to 21 Days
$405.90
Details
Human Rabbit Alexa Fluor 555 IF (p)   100 μL Log in to see 14 to 21 Days
$405.90
Details

WNK4 Antibodies by Reactivity, Application, Clonality and Conjugate

Attributes Applications Host Clonality Conjugate
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Top referenced anti-WNK4 Antibodies

  1. Human Polyclonal WNK4 Primary Antibody for EM, IHC - ABIN153223 : Wilson, Disse-Nicodème, Choate, Ishikawa, Nelson-Williams, Desitter, Gunel, Milford, Lipkin, Achard, Feely, Dussol, Berland, Unwin, Mayan, Simon, Farfel, Jeunemaitre, Lifton: Human hypertension caused by mutations in WNK kinases. in Science (New York, N.Y.) 2001 (PubMed)
    Show all 7 Pubmed References

More Antibodies against WNK4 Interaction Partners

Human WNK Lysine Deficient Protein Kinase 4 (WNK4) interaction partners

  1. This study provides substantial new insights into the role of phosphorylation of KLHL3 (show KLHL3 Antibodies) in regulating the interaction with WNK4

  2. The distribution of allele frequency and genotype of WNK4 gene Ala589Ser polymorphism showed significant differences between essential hypertension subjects, with or without type 2 diabetes mellitus, and normotensive subjects.

  3. Data indicate that WNK lysine deficient protein kinase 4 protein (WNK4) was degraded not only by proteasomes but also by atypical protein kinase C scaffold protein p62 (p62)-kelch-like 3 protein (KLHL3)-mediated selective autophagy.

  4. this meta-analysis suggested that WNK4 G1155942T and C6749T gene polymorphisms may contribute to the susceptibility and development of hypertension.

  5. Akt (show AKT1 Antibodies) and PKA phosphorylated KLHL3 (show KLHL3 Antibodies) at S433, and phosphorylation of KLHL3 (show KLHL3 Antibodies) by PKA inhibited WNK4 degradation.

  6. WNK4 is a substrate of SFKs and the association of c-Src (show SRC Antibodies) and PTP-1D (show PTPN11 Antibodies) with WNK4 at Tyr (show TYR Antibodies)(1092) and Tyr (show TYR Antibodies)(1143) plays an important role in modulating the inhibitory effect of WNK4 on ROMK (show KCNJ1 Antibodies)

  7. WNK4 inhibits SNARE (show NAPA Antibodies) formation of syntaxin 13 (show STX12 Antibodies) with VAMP2 (show VAMP2 Antibodies).

  8. Regulation of WNK4 by CUL3 (show CUL3 Antibodies) and its relationship to blood pressure regulation and electrolyte homeostasis. [Review]

  9. WNK4 inhibits Large-conductance, Ca(2 )-activated K( ) channel activity, in part, by increasing channel degradation through an ubiquitin-dependent pathway.

  10. analysis of how mutations of KLHL3 (show KLHL3 Antibodies) show less ability to ubiquitinate WNK4 because of KLHL3 (show KLHL3 Antibodies)'s low stability and/or decreased binding to CUL3 (show CUL3 Antibodies) or WNK4

Mouse (Murine) WNK Lysine Deficient Protein Kinase 4 (WNK4) interaction partners

  1. However, phosphorylation of SPAK (show STK39 Antibodies) and NCC (show SLC12A3 Antibodies) at distal convoluted tubules were almost completely absent even in WNK4(-/-)KLHL3 (show KLHL3 Antibodies)(R528H/R528H) mice. In conclusion, increased WNK1 (show WNK1 Antibodies) was unable to compensate for WNK4 deficiency and phosphorylate the NCC (show SLC12A3 Antibodies), indicating that WNK4 is indispensable for the onset of PHAII.

  2. ENaC (show SCNN1A Antibodies) and ROMK (show KCNJ1 Antibodies) channel activity in kidney tubules are inhibited in TgWnk4(pseudoaldosteronism type II) mice. Wnk4(PHAII)-induced inhibition of ENaC (show SCNN1A Antibodies) and ROMK (show KCNJ1 Antibodies) may contribute to the suppression of K(+) secretion in the tubules.

  3. Accordingly, medullary WNK4 protein levels were significantly increased in the kidneys of KLHL2 (show KLHL2 Antibodies)(-/-) mice. KLHL2 (show KLHL2 Antibodies) is indeed a physiological regulator of WNK4 in vivo; however, its function might be different from that of KLHL3 (show KLHL3 Antibodies) because KLHL2 (show KLHL2 Antibodies) mainly localized in medulla.

  4. The results indicate that quite modest changes in dietary K intake affect plasma [K] and thiazide-sensitive NaCl cotransporter activity. These effects are mediated largely by WNK4, as this kinase exhibits unique Cl-sensitive properties.

  5. the increased NCC (show SLC12A3 Antibodies) expression and activation is present in CMA which is highly associated with the enhanced WNK4-SPAK (show STK39 Antibodies) signal pathway using WNK4-/- and SPAK (show STK39 Antibodies)-/- mice.

  6. increased protein expression levels of WNK1 (show WNK1 Antibodies) and WNK4 kinases cause PHAII by KLHL3 (show KLHL3 Antibodies) R528H mutation due to impaired KLHL3 (show KLHL3 Antibodies)-Cullin3-mediated ubiquitination.

  7. KLHL3 (show KLHL3 Antibodies) is phosphorylated at serine 433 in the Kelch domain (a site frequently mutated in hypertension with hyperkalemia) by protein kinase C (show PKC Antibodies) in cultured cells and that this phosphorylation prevents WNK4 binding and degradation.

  8. WNK4 is the major positive regulator of NCC (show SLC12A3 Antibodies) in the kidneys.

  9. WNK1 (show WNK1 Antibodies) stimulates the activity of the Na-Cl cotransporter (show SLC12A3 Antibodies) via SPAK (show STK39 Antibodies), an effect antagonized by WNK4.

  10. in addition to SPAK (show STK39 Antibodies) and OSR1 (show OSR1 Antibodies), WNK4 is able to anchor itself to the N-terminal domain of NKCC1 (show SLC12A2 Antibodies) and to promote cotransporter activation.

WNK4 Antigen Profile

Protein Summary

This gene encodes a member of the WNK family of serine-threonine protein kinases. The kinase is part of the tight junction complex in kidney cells, and regulates the balance between NaCl reabsorption and K(+) secretion. The kinase regulates the activities of several types of ion channels, cotransporters, and exchangers involved in electrolyte flux in epithelial cells. Mutations in this gene result in pseudohypoaldosteronism type IIB.

Gene names and symbols associated with WNK4

  • WNK lysine deficient protein kinase 4 (WNK4) antibody
  • WNK lysine deficient protein kinase 4 (Wnk4) antibody
  • 2010002J11Rik antibody
  • Ac2-059 antibody
  • Pha2b antibody
  • Prkwnk4 antibody
  • WNK4 antibody

Protein level used designations for WNK4

WNK lysine deficient protein kinase 4 , protein kinase lysine-deficient 4 , protein kinase with no lysine 4 , serine/threonine-protein kinase WNK4 , protein kinase, lysine deficient 4 , WNK4 Ser/Thr kinase , protein kinase, lysine-deficient 4

GENE ID SPECIES
454699 Pan troglodytes
490959 Canis lupus familiaris
100139742 Bos taurus
100617641 Monodelphis domestica
65266 Homo sapiens
69847 Mus musculus
287715 Rattus norvegicus
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