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anti-WW Domain Containing Oxidoreductase (WWOX) Antibodies

WW domain-containing proteins are found in all eukaryotes and play an important role in the regulation of a wide variety of cellular functions such as protein degradation, transcription, and RNA splicing. Additionally we are shipping WW Domain Containing Oxidoreductase Proteins (14) and WW Domain Containing Oxidoreductase Kits (8) and many more products for this protein.

list all antibodies Gene Name GeneID UniProt
WWOX 51741 Q9NZC7
WWOX 80707 Q91WL8
WWOX 292041  
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Top anti-WW Domain Containing Oxidoreductase Antibodies at antibodies-online.com

Showing 10 out of 82 products:

Catalog No. Reactivity Host Conjugate Application Images Quantity Supplier Delivery Price Details
Human Rabbit Un-conjugated EIA, WB WWOX Antibody (C-term) western blot analysis in mouse testis tissue ly... 0.4 mL Log in to see 6 to 8 Days
$390.50
Details
Human Rabbit Un-conjugated DB, EIA, WB 0.1 mg Log in to see 6 to 8 Days
$456.50
Details
Mouse Rabbit Un-conjugated WB WWOX Antibody (C-term) (ABIN658713) western blot analysis in mouse tes... 400 μL Log in to see 10 to 11 Days
$324.50
Details
Human Rabbit Un-conjugated IHC, ELISA, WB Western blot analysis of extracts from HepG2 cells treated with PMA 12... Immunohistochemistry analysis of paraffin-embedded human colon carcino... 100 μg Log in to see 2 to 3 Days
$275.00
Details
Human Rabbit Un-conjugated ELISA, WB Western blot analysis of extracts from HepG2 cells, using WWOX Antibod... 100 μg Log in to see 2 to 3 Days
$275.00
Details
Human Rabbit Un-conjugated DB, EIA, IHC (fro), WB   0.1 mg Log in to see 6 to 8 Days
$456.50
Details
Human Rabbit Un-conjugated DB, EIA   0.1 mg Log in to see 6 to 8 Days
$456.50
Details
Human Rabbit Un-conjugated DB, EIA   0.1 mg Log in to see 6 to 8 Days
$456.50
Details
Human Rabbit Un-conjugated ELISA, WB 100 μL Log in to see 8 to 10 Days
$478.50
Details
Human Rabbit Un-conjugated IHC, ELISA, WB 100 μg Log in to see 6 to 11 Days
$327.14
Details

WWOX Antibodies by Reactivity, Application, Clonality and Conjugate

Attributes Applications Host Clonality
Human , , , ,
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Mouse (Murine) , , , ,
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Rat (Rattus) , , , ,

Top referenced anti-WW Domain Containing Oxidoreductase Antibodies

  1. Human Polyclonal WWOX Primary Antibody for EIA, WB - ABIN955590 : Maeda, Semba, Nakayama, Yanagihara, Yokozaki: Loss of WW domain-containing oxidoreductase expression in the progression and development of gastric carcinoma: clinical and histopathologic correlations. in Virchows Archiv : an international journal of pathology 2010 (PubMed)
    Show all 4 references for ABIN955590

  2. Human Polyclonal WWOX Primary Antibody for DB, EIA - ABIN493568 : Yendamuri, Kuroki, Trapasso, Henry, Dumon, Huebner, Williams, Kaiser, Croce: WW domain containing oxidoreductase gene expression is altered in non-small cell lung cancer. in Cancer research 2003 (PubMed)
    Show all 4 references for ABIN493568

  3. Human Polyclonal WWOX Primary Antibody for DB, EIA - ABIN493566 : Chang, Doherty, Ensign: JNK1 physically interacts with WW domain-containing oxidoreductase (WOX1) and inhibits WOX1-mediated apoptosis. in The Journal of biological chemistry 2003 (PubMed)
    Show all 2 references for ABIN493566

  4. Mouse (Murine) Polyclonal WWOX Primary Antibody for WB - ABIN658713 : Kurek, Del Mare, Salah, Abdeen, Sadiq, Lee, Gaudio, Zanesi, Jones, DeYoung, Amir, Gebhardt, Warman, Stein, Stein, Lian, Aqeilan: Frequent attenuation of the WWOX tumor suppressor in osteosarcoma is associated with increased tumorigenicity and aberrant RUNX2 expression. in Cancer research 2010 (PubMed)
    Show all 2 references for ABIN658713

  5. Human Polyclonal WWOX Primary Antibody for DB, EIA - ABIN493564 : Haecker, Gross-Hardt, Geiges, Sarkar, Breuninger, Herrmann, Laux: Expression dynamics of WOX genes mark cell fate decisions during early embryonic patterning in Arabidopsis thaliana. in Development (Cambridge, England) 2004 (PubMed)
    Show all 2 references for ABIN493564

More Antibodies against WW Domain Containing Oxidoreductase Interaction Partners

Fruit Fly (Drosophila melanogaster) WW Domain Containing Oxidoreductase (WWOX) interaction partners

  1. the ability of WWOX to facilitate escape from mitochondrial damage-induced glycolysis (Warburg effect) is, therefore, a plausible mechanism for its tumor suppressor activity.

  2. Together these results provide a molecular basis for the tumor suppressor functions of WWOX and the better prognosis observed in cancer patients with higher levels of WWOX activity.

  3. Aberrant WWOX expression contributes to the altered metabolism in cancer.

  4. study finds significant proportion of Wwox interactors have roles in aerobic metabolism; Wwox contributes to pathways involving aerobic metabolism and oxidative stress, providing an explanation for the 'non-classical tumour suppressor' behaviour of WWOX

  5. the Drosophila orthologue of the human WWOX gene was identified. the protective function of DmWWOX in response to irradiation in Drosophila is conserved with human WWOX

Cow (Bovine) WW Domain Containing Oxidoreductase (WWOX) interaction partners

  1. data show that the chromosomal location of WWOX is conserved between man and 4 major domesticated species. Moreover, the annotation of the bovine gene also suggests a highly conserved genomic arrangement, including number and size of introns

Human WW Domain Containing Oxidoreductase (WWOX) interaction partners

  1. Our data suggest that the loss genotypes of CNV-67048 in WWOX predispose their carriers to chronic obstructive pulmonary disease.

  2. WWOX played roles in metabolic regulation and controlling central nervous system development. [review]

  3. Data suggest that Pc2 (show KRT6B Antibodies)- (polycomb (show CBX2 Antibodies) repressive complex 2-) mediated SUMOylation of WWOX is essential for suppressive activity of WWOX in prostate cancer tumorigenesis.

  4. Compared to the controls, upregulation of WWOX and its Tyr33 phosphorylation was observed in the head region of all pterygium specimens. In the head and body of the pterygium specimens, WWOX expression was significantly higher than in the controls.

  5. Down regulation of WWOX is involved in tumorigenesis in intrahepatic cholangiocarcinoma.

  6. Decreased WWOX expression may interfere with gemcitabine sensitivity, and allele-specific binding at rs11644332 might be a causative molecular mechanism behind the clinically observed associations.

  7. Hypermethylation of WWOX gene is associated with Epstein-Barr virus-associated gastric carcinomas.

  8. The WWOX gene can downregulate the expression levels of cell cycle proteins cyclin E (show CCNE1 Antibodies)-CDK2 (show CDK2 Antibodies) and cyclin D1 (show CCND1 Antibodies)-CDK4 (show CDK4 Antibodies), which affects the cell cycle of ovarian cancer stem cells.

  9. The inhibition of the transcriptional activity of BCL9-2 (show BCL9L Antibodies) by WWOX and HDAC3 (show HDAC3 Antibodies) constitutes a new molecular mechanism and provides new insight for a broad range of cancers.

  10. Results suggest that WWOX gene plays a role in the regulation of epithelial to mesenchymal transition process in endometrial cancer by controlling the expression of proteins associated with cell motility and suppressing mesenchymal markers.

Mouse (Murine) WW Domain Containing Oxidoreductase (WWOX) interaction partners

  1. Both Wwox null and Wwoxhep-/- mice demonstrated reductions in ApoA-I (show APOA1 Antibodies) and Abca1 (show ABCA1 Antibodies) levels, critical components in reverse cholesterol transport and generation of nascent HDL (show HSD11B1 Antibodies) particles.

  2. Aberrant WWOX expression contributes to the altered metabolism in cancer.

  3. WWOX plays a critical role in normal central nervous system development and disease.

  4. WWOX has many functions, and its deletion affects cellular metabolism and neoplastic progression.

  5. Wwox-deficient mice develop normally but succumb to a lethal hypoglycemia early in life. WWOX as a tumor suppressor with emerging role in regulation of aerobic glycolysis.

  6. These findings identify a novel role for the tumor suppressor WWOX and show that loss of WWOX expression may drive genomic instability

  7. Modeling WWOX inactivation revealed a complex phenotype including postnatal lethality, defects in bone metabolism and steroidogenesis and tumor suppressor function resulting in osteosarcomas.

  8. WWOX ablation leads to impaired mammary ductal growth. Moreover, targeted deletion of WWOX is associated with increased levels of fibronectin (show FN1 Antibodies), a component of the extracellular matrix.

  9. the WWOX tumor suppressor gene has in preventing tumorigenesis in breast cancer

  10. analysis of the effect of the Wwox tumor suppressor gene in a knockout model

WW Domain Containing Oxidoreductase (WWOX) Antigen Profile

Protein Summary

WW domain-containing proteins are found in all eukaryotes and play an important role in the regulation of a wide variety of cellular functions such as protein degradation, transcription, and RNA splicing. This gene encodes a protein which contains 2 WW domains and a short-chain dehydrogenase/reductase domain (SRD). The highest normal expression of this gene is detected in hormonally regulated tissues such as testis, ovary, and prostate. This expression pattern and the presence of an SRD domain suggest a role for this gene in steroid metabolism. The encoded protein is more than 90% identical to the mouse protein, which is an essential mediator of tumor necrosis factor-alpha-induced apoptosis, suggesting a similar, important role in apoptosis for the human protein. In addition, there is evidence that this gene behaves as a suppressor of tumor growth. Alternative splicing of this gene generates transcript variants that encode different isoforms.

Gene names and symbols associated with WWOX

  • WW domain containing oxidoreductase (Wwox) antibody
  • WW domain-containing oxidoreductase (Wwox) antibody
  • WW domain containing oxidoreductase (WWOX) antibody
  • WW domain-containing oxidoreductase (CpipJ_CPIJ004939) antibody
  • WW domain-containing oxidoreductase (MCYG_01584) antibody
  • WW domain-containing oxidoreductase (VDBG_05631) antibody
  • WW domain-containing oxidoreductase (VDBG_01326) antibody
  • WW domain-containing oxidoreductase (VDBG_06753) antibody
  • WW domain-containing oxidoreductase (Tsp_03967) antibody
  • WW domain-containing oxidoreductase (LOC100229880) antibody
  • WW domain-containing oxidoreductase (LOC100284583) antibody
  • WW domain containing oxidoreductase (wwox) antibody
  • 5330426P09Rik antibody
  • 9030416C10Rik antibody
  • anon-EST:Posey177 antibody
  • CG7221 antibody
  • D16S432E antibody
  • Dmel\\CG7221 antibody
  • DmWWOX antibody
  • FOR antibody
  • FRA16D antibody
  • GB11795 antibody
  • HHCMA56 antibody
  • PRO0128 antibody
  • SDR41C1 antibody
  • WOX1 antibody
  • WWOX antibody
  • zgc:55975 antibody

Protein level used designations for WWOX

CG7221-PA , Wwox-PA , WW domain-containing oxidoreductase , retinol dehydrogenase 12 , WW domain containing oxidoreductase , WW domain-containing protein WWOX , fragile site FRA16D oxidoreductase , short chain dehydrogenase/reductase family 41C, member 1 , WW-domain oxidoreductase

GENE ID SPECIES
34090 Drosophila melanogaster
411815 Apis mellifera
610120 Canis lupus familiaris
618792 Bos taurus
715635 Macaca mulatta
737907 Pan troglodytes
6036407 Culex quinquefasciatus
9230790 Arthroderma otae CBS 113480
9531509 Verticillium alfalfae VaMs.102
9536255 Verticillium alfalfae VaMs.102
9537317 Verticillium alfalfae VaMs.102
10904221 Trichinella spiralis
100229880 Taeniopygia guttata
100284583 Zea mays
51741 Homo sapiens
415801 Gallus gallus
100172779 Pongo abelii
393887 Danio rerio
80707 Mus musculus
292041 Rattus norvegicus
Selected quality suppliers for anti-WW Domain Containing Oxidoreductase (WWOX) Antibodies
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