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WW domain-containing proteins are found in all eukaryotes and play an important role in the regulation of a wide variety of cellular functions such as protein degradation, transcription, and RNA splicing. Additionally we are shipping WWOX Proteins (14) and WWOX Kits (8) and many more products for this protein.
Showing 10 out of 86 products:
Human Polyclonal WWOX Primary Antibody for DB, EIA - ABIN493568
Yendamuri, Kuroki, Trapasso, Henry, Dumon, Huebner, Williams, Kaiser, Croce: WW domain containing oxidoreductase gene expression is altered in non-small cell lung cancer. in Cancer research 2003
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Human Polyclonal WWOX Primary Antibody for EIA, WB - ABIN955590
Maeda, Semba, Nakayama, Yanagihara, Yokozaki: Loss of WW domain-containing oxidoreductase expression in the progression and development of gastric carcinoma: clinical and histopathologic correlations. in Virchows Archiv : an international journal of pathology 2010
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Human Polyclonal WWOX Primary Antibody for DB, EIA - ABIN493566
Chang, Doherty, Ensign: JNK1 physically interacts with WW domain-containing oxidoreductase (WOX1) and inhibits WOX1-mediated apoptosis. in The Journal of biological chemistry 2003
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Mouse (Murine) Polyclonal WWOX Primary Antibody for WB - ABIN658713
Kurek, Del Mare, Salah, Abdeen, Sadiq, Lee, Gaudio, Zanesi, Jones, DeYoung, Amir, Gebhardt, Warman, Stein, Stein, Lian, Aqeilan: Frequent attenuation of the WWOX tumor suppressor in osteosarcoma is associated with increased tumorigenicity and aberrant RUNX2 expression. in Cancer research 2010
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Human Polyclonal WWOX Primary Antibody for DB, EIA - ABIN493564
Haecker, Gross-Hardt, Geiges, Sarkar, Breuninger, Herrmann, Laux: Expression dynamics of WOX genes mark cell fate decisions during early embryonic patterning in Arabidopsis thaliana. in Development (Cambridge, England) 2004
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the ability of WWOX to facilitate escape from mitochondrial damage-induced glycolysis (Warburg effect) is, therefore, a plausible mechanism for its tumor suppressor activity.
Together these results provide a molecular basis for the tumor suppressor functions of WWOX and the better prognosis observed in cancer patients with higher levels of WWOX activity.
Aberrant WWOX expression contributes to the altered metabolism in cancer.
study finds significant proportion of Wwox interactors have roles in aerobic metabolism; Wwox contributes to pathways involving aerobic metabolism and oxidative stress, providing an explanation for the 'non-classical tumour suppressor' behaviour of WWOX
the Drosophila orthologue of the human WWOX gene was identified. the protective function of DmWWOX in response to irradiation in Drosophila is conserved with human WWOX
data show that the chromosomal location of WWOX is conserved between man and 4 major domesticated species. Moreover, the annotation of the bovine gene also suggests a highly conserved genomic arrangement, including number and size of introns
WWOX mutation is associated with early infantile epileptic encephalopathy.
Our data suggest that the loss genotypes of CNV-67048 in WWOX predispose their carriers to chronic obstructive pulmonary disease.
WWOX played roles in metabolic regulation and controlling central nervous system development. [review]
Data suggest that Pc2 (show KRT6B Antibodies)- (polycomb (show CBX2 Antibodies) repressive complex 2-) mediated SUMOylation of WWOX is essential for suppressive activity of WWOX in prostate cancer tumorigenesis.
Compared to the controls, upregulation of WWOX and its Tyr33 phosphorylation was observed in the head region of all pterygium specimens. In the head and body of the pterygium specimens, WWOX expression was significantly higher than in the controls.
Down regulation of WWOX is involved in tumorigenesis in intrahepatic cholangiocarcinoma.
Decreased WWOX expression may interfere with gemcitabine sensitivity, and allele-specific binding at rs11644332 might be a causative molecular mechanism behind the clinically observed associations.
Hypermethylation of WWOX gene is associated with Epstein-Barr virus-associated gastric carcinomas.
The WWOX gene can downregulate the expression levels of cell cycle proteins cyclin E (show CCNE1 Antibodies)-CDK2 (show CDK2 Antibodies) and cyclin D1 (show CCND1 Antibodies)-CDK4 (show CDK4 Antibodies), which affects the cell cycle of ovarian cancer stem cells.
The inhibition of the transcriptional activity of BCL9-2 (show BCL9L Antibodies) by WWOX and HDAC3 (show HDAC3 Antibodies) constitutes a new molecular mechanism and provides new insight for a broad range of cancers.
Both Wwox null and Wwoxhep-/- mice demonstrated reductions in ApoA-I (show APOA1 Antibodies) and Abca1 (show ABCA1 Antibodies) levels, critical components in reverse cholesterol transport and generation of nascent HDL (show HSD11B1 Antibodies) particles.
WWOX plays a critical role in normal central nervous system development and disease.
WWOX has many functions, and its deletion affects cellular metabolism and neoplastic progression.
Wwox-deficient mice develop normally but succumb to a lethal hypoglycemia early in life. WWOX as a tumor suppressor with emerging role in regulation of aerobic glycolysis.
These findings identify a novel role for the tumor suppressor WWOX and show that loss of WWOX expression may drive genomic instability
Modeling WWOX inactivation revealed a complex phenotype including postnatal lethality, defects in bone metabolism and steroidogenesis and tumor suppressor function resulting in osteosarcomas.
WWOX ablation leads to impaired mammary ductal growth. Moreover, targeted deletion of WWOX is associated with increased levels of fibronectin (show FN1 Antibodies), a component of the extracellular matrix.
the WWOX tumor suppressor gene has in preventing tumorigenesis in breast cancer
analysis of the effect of the Wwox tumor suppressor gene in a knockout model
WW domain-containing proteins are found in all eukaryotes and play an important role in the regulation of a wide variety of cellular functions such as protein degradation, transcription, and RNA splicing. This gene encodes a protein which contains 2 WW domains and a short-chain dehydrogenase/reductase domain (SRD). The highest normal expression of this gene is detected in hormonally regulated tissues such as testis, ovary, and prostate. This expression pattern and the presence of an SRD domain suggest a role for this gene in steroid metabolism. The encoded protein is more than 90% identical to the mouse protein, which is an essential mediator of tumor necrosis factor-alpha-induced apoptosis, suggesting a similar, important role in apoptosis for the human protein. In addition, there is evidence that this gene behaves as a suppressor of tumor growth. Alternative splicing of this gene generates transcript variants that encode different isoforms.
, WW domain-containing oxidoreductase
, retinol dehydrogenase 12
, WW domain containing oxidoreductase
, WW domain-containing protein WWOX
, fragile site FRA16D oxidoreductase
, short chain dehydrogenase/reductase family 41C, member 1
, WW-domain oxidoreductase