Use your antibodies-online credentials, if available.
No Products on your Comparison List.
Your basket is empty.
Find out more
The protein encoded by XPNPEP3 belongs to the family of X-pro-aminopeptidases that utilize a metal cofactor, and remove the N-terminal amino acid from peptides with a proline residue in the penultimate position. Additionally we are shipping X-Prolyl Aminopeptidase (Aminopeptidase P) 3, Putative Antibodies (45) and many more products for this protein.
Showing 6 out of 6 products:
Data suggest that human XPNPEP3, Ashbya gossypii Icp55, and Fusarium graminearum Icp55 exhibit structural and functional properties of genuine Xaa-Pro specific aminopeptidases; these enzymes appear to function in the previously observed mitochondrial role of Icp55 in processing of Nfs1 (show NFS1 Proteins) (mitochondrial cysteine desulfurase (show NFS1 Proteins)) substrate. [Icp55 = intermediate-cleavage metalloexopeptidases 55]
The findings reveal that APP3m is a new member of the TNF (show TNF Proteins)-TNFR2 (show TNFRSF1B Proteins) signaling complex and characterize an APP3-mediated TNFR2 (show TNFRSF1B Proteins) signal transduction mechanism that induces activation of JNK1 (show MAPK8 Proteins) and JNK2 (show MAPK9 Proteins).
Individuals with mutations in XPNPEP3, which encodes a mitochondrial protein (show COX6B2 Proteins), develop a nephronophthisis-like nephropathy.
The protein encoded by this gene belongs to the family of X-pro-aminopeptidases that utilize a metal cofactor, and remove the N-terminal amino acid from peptides with a proline residue in the penultimate position. This protein has been shown to localize to the mitochondria of renal cells, and have a role in ciliary function. Mutations in this gene are associated with nephronophthisis-like nephropathy-1. Alternatively spliced transcript variants encoding different isoforms have been noted for this gene, however, expression of some of these isoforms in vivo is not known.
X-prolyl aminopeptidase (aminopeptidase P) 3, putative
, X-Pro aminopeptidase 3
, probable Xaa-Pro aminopeptidase 3
, aminopeptidase P3