XiAP Associated Factor 1 Proteins (XAF1)

XAF1 encodes a protein which binds to and counteracts the inhibitory effect of a member of the IAP (inhibitor of apoptosis) protein family. Additionally we are shipping XAF1 Antibodies (89) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
XAF1 54739 Q6GPH4
Mouse XAF1 XAF1 327959 Q5NBU8
Rat XAF1 XAF1 679600  
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Top XAF1 Proteins at antibodies-online.com

Showing 4 out of 5 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
Insect Cells Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 50 Days
HOST_Wheat germ Human GST tag 10 μg Log in to see 11 to 12 Days
Yeast Cow His tag   1 mg Log in to see 60 to 71 Days
HOST_Escherichia coli (E. coli) Human Un-conjugated   100 μg Log in to see 2 to 3 Days

XAF1 Proteins by Origin and Source

Origin Expressed in Conjugate
Human , ,

More Proteins for XiAP Associated Factor 1 (XAF1) Interaction Partners

Human XiAP Associated Factor 1 (XAF1) interaction partners

  1. human genome-wide gene expression profile assay was used to screen the targets of miR (show MLXIP Proteins)-3131. The overexpressed miR (show MLXIP Proteins)-3131 could lead to a significant decrease of DTHD1 and XAF1 mRNA level.

  2. XAF1 acts as a feedback regulator of the TNF (show TNF Proteins) receptor signaling pathway to suppress NF-kappaB (show NFKB1 Proteins) activation

  3. Taken together, our results suggest that ROS (show ROS1 Proteins) generation might be a predisposing event in berberine-induced mitochondrial apoptosis in EBV-transformed B cells through the upregulation of XAF1 and GADD45alpha (show GADD45A Proteins) expression by MAPK (show MAPK1 Proteins) and functional p53 (show TP53 Proteins).

  4. Expression of XAF1 and TAp73 (show TP73 Proteins) was also upregulated in casticin-treated T24 cells.

  5. Data show that X-linked inhibitor of apoptosis protein (XIAP (show XIAP Proteins)) mRNA and protein expression increased, whereas XIAP-associated factor 1 (XAF1) mRNA and protein expression decreased with the growth of radiation dose and exposure time.

  6. the present study was the first to construct an adenovirus which coexpressed XAF1 and TNFalpha (show TNF Proteins) in the same open reading frame and expressed them proportionally. As AdXAF1&TNFalpha (show TNF Proteins) inhibited HCC (show FAM126A Proteins) cells with enhanced efficiency, it may be applicable for the treatment of HCC (show FAM126A Proteins).

  7. SHC1 (show SHC1 Proteins) regulates the alternative splicing of XAF1 in extracellular matrix-detachment induced autophagy to coordinate with the anoikic cell death.

  8. Our study identified a novel splice variant of XAF1 in cancer cells

  9. Underexpression of XAF1 confers cisplatin-resistance in ovarian carcinoma.

  10. Restored XAF1 expression inhibits cell proliferation and induces cell apoptosis in human lung adenocarcinoma cell line A549. Furthermore, XAF1 may activate associated apoptotic signaling pathways in A549 cell line.

Mouse (Murine) XiAP Associated Factor 1 (XAF1) interaction partners

  1. Interferon gamma (show IFNG Proteins) induces XAF1 and Noxa (show PMAIP1 Proteins) expression and potentiates apoptosis by STAT3 (show STAT3 Proteins) activation

  2. XAF1 possesses a potential antiangiogenesis effect. Suppressed expression of Tie-1 (show TIE1 Proteins), Ang-1 (show ANGPT1 Proteins), Ang-2 (show ANGPT2 Proteins) and c-Myc (show MYC Proteins) may be mechanistically responsible for the observed antiangiogenesis effect.

XAF1 Protein Profile

Protein Summary

This gene encodes a protein which binds to and counteracts the inhibitory effect of a member of the IAP (inhibitor of apoptosis) protein family. IAP proteins bind to and inhibit caspases which are activated during apoptosis. The proportion of IAPs and proteins which interfere with their activity, such as the encoded protein, affect the progress of the apoptosis signaling pathway. Multiple transcript variants encoding different isoforms have been found for this gene.

Gene names and symbols associated with XAF1

  • zgc:153893 (zgc:153893)
  • XIAP associated factor 1 (XAF1)
  • XIAP associated factor 1 (Xaf1)
  • XIAP associated factor-1 (XAF1)
  • BIRC4BP protein
  • Fbxo39 protein
  • HSXIAPAF1 protein
  • XIAPAF1 protein

Protein level used designations for XAF1

XIAP-associated factor 1 , BIRC4 binding protein , BIRC4-binding protein , F-box protein 39 , novel TRAF-type zinc finger protein

767709 Danio rerio
54739 Homo sapiens
327959 Mus musculus
509740 Bos taurus
679600 Rattus norvegicus
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