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XAF1 encodes a protein which binds to and counteracts the inhibitory effect of a member of the IAP (inhibitor of apoptosis) protein family. Additionally we are shipping XAF1 Antibodies (92) and many more products for this protein.
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Taken together, our results suggest that ROS (show ROS1 Proteins) generation might be a predisposing event in berberine-induced mitochondrial apoptosis in EBV-transformed B cells through the upregulation of XAF1 and GADD45alpha (show GADD45A Proteins) expression by MAPK (show MAPK1 Proteins) and functional p53 (show TP53 Proteins).
Expression of XAF1 and TAp73 (show TP73 Proteins) was also upregulated in casticin-treated T24 cells.
Data show that X-linked inhibitor of apoptosis protein (XIAP (show XIAP Proteins)) mRNA and protein expression increased, whereas XIAP-associated factor 1 (XAF1) mRNA and protein expression decreased with the growth of radiation dose and exposure time.
the present study was the first to construct an adenovirus which coexpressed XAF1 and TNFalpha (show TNF Proteins) in the same open reading frame and expressed them proportionally. As AdXAF1&TNFalpha (show TNF Proteins) inhibited HCC (show FAM126A Proteins) cells with enhanced efficiency, it may be applicable for the treatment of HCC (show FAM126A Proteins).
SHC1 (show SHC1 Proteins) regulates the alternative splicing of XAF1 in extracellular matrix-detachment induced autophagy to coordinate with the anoikic cell death.
Our study identified a novel splice variant of XAF1 in cancer cells
Underexpression of XAF1 confers cisplatin-resistance in ovarian carcinoma.
Restored XAF1 expression inhibits cell proliferation and induces cell apoptosis in human lung adenocarcinoma cell line A549. Furthermore, XAF1 may activate associated apoptotic signaling pathways in A549 cell line.
Up-regulation of XAF1 distinctly increased apoptosis in colorectal cancer cells administered cisplatin.
XAF1 stimulates HIPK2 (show HIPK2 Proteins)-mediated Ser (show SIGLEC1 Proteins)-46 phosphorylation of p53 (show TP53 Proteins) and XAF1 also steps up the termination of p53 (show TP53 Proteins)-mediated cell-cycle arrest by activating ZNF313 (show RNF114 Proteins).
Interferon gamma (show IFNG Proteins) induces XAF1 and Noxa (show PMAIP1 Proteins) expression and potentiates apoptosis by STAT3 (show STAT3 Proteins) activation
XAF1 possesses a potential antiangiogenesis effect. Suppressed expression of Tie-1 (show TIE1 Proteins), Ang-1 (show ANGPT1 Proteins), Ang-2 (show ANGPT2 Proteins) and c-Myc (show MYC Proteins) may be mechanistically responsible for the observed antiangiogenesis effect.
This gene encodes a protein which binds to and counteracts the inhibitory effect of a member of the IAP (inhibitor of apoptosis) protein family. IAP proteins bind to and inhibit caspases which are activated during apoptosis. The proportion of IAPs and proteins which interfere with their activity, such as the encoded protein, affect the progress of the apoptosis signaling pathway. Multiple transcript variants encoding different isoforms have been found for this gene.
XIAP-associated factor 1
, BIRC4 binding protein
, BIRC4-binding protein
, F-box protein 39
, novel TRAF-type zinc finger protein